公开(公告)号：WO2015116775A1

公开(公告)日：2015-08-06

申请号：PCT/US2015/013441

申请日：2015-01-29

申请人： TRUDEAU INSTITUTE ,  RENSSELAER POLYTECHNIC INSTITUTE

发明人： LEADBETTER, Elizabeth ,  AMIEL, Eyal ,  VOMHOF-DEKREY, Emille ,  LINHARDT, Robert ,  WEYERS, Amanda ,  MIAO, Jianjun

IPC分类号： A61K39/39

CPC分类号： A61K39/092 ,  A61K9/127 ,  A61K9/5153 ,  A61K9/5192 ,  A61K2039/55555 ,  A61K2039/55572 ,  A61K2039/575 ,  Y02A50/412 ,  Y02A50/484

摘要： The invention relates, in part, to nanoparticles, methods for preparing nanoparticles and methods of administering nanoparticles for immune stimulation. An immune-stimulating nanoparticle of the invention may include, at least in part, a polymer substrate comprising a biodegradable polymer and may include at least one antigen and/or at least one adjuvant.

摘要翻译： 本发明部分涉及纳米颗粒，制备纳米颗粒的方法和用于免疫刺激的纳米颗粒的施用方法。 本发明的免疫刺激纳米颗粒可以至少部分地包括包含可生物降解聚合物的聚合物底物，并且可以包括至少一种抗原和/或至少一种佐剂。

公开(公告)号：WO2019143924A1

公开(公告)日：2019-07-25

申请号：PCT/US2019/014176

申请日：2019-01-18

申请人： RENSSELAER POLYTECHNIC INSTITUTE

发明人： LINHARDT, Robert ,  ZHAO, Jing ,  ZHANG, Fuming ,  MUNTENDAM, Pieter

IPC分类号： A61K31/715 ,  C08B37/00

摘要： A therapeutic composition includes a polysaccharide, isolated from a member of the genus Cucurbita , e.g., pumpkin, having a backbone including alternating α-L-rhamnosyl (α-L-Rha p ) and α-D-galactopyranosyluronic acid (α-D-Gal p A) residues, and a side chain attached to the backbone including β-D-galactan (β-D-Gal p ), α-L-arabinofuranosyl (α-L-Ara f ), or combinations thereof, and a pharmaceutically acceptable excipient. A β-D-Galp side chain is attached to the backbone at the C-4 carbon of at least one α-L-Rhap of the backbone. At least one α-L-Araf is attached to the β-D-Galp side chain. The a-L-Araf is attached to the β-D-Galp side chain via the C-3 carbon of the β-D-Galp. The polysaccharide is effective for treating a galectin-3 dependent disorder by binding to the carbohydrate recognition domain of galectin-3, resulting in inhibition of galectin-3 activity.

公开(公告)号：WO2019143924A9

公开(公告)日：2019-07-25

申请号：PCT/US2019/014176

申请日：2019-01-18

申请人： RENSSELAER POLYTECHNIC INSTITUTE

发明人： LINHARDT, Robert ,  ZHAO, Jing ,  ZHANG, Fuming ,  MUNTENDAM, Pieter

IPC分类号： A61K31/715 ,  C08B37/00

摘要： A therapeutic composition includes a polysaccharide, isolated from a member of the genus Cucurbita , e.g., pumpkin, having a backbone including alternating α-L-rhamnosyl (α-L-Rha p ) and α-D-galactopyranosyluronic acid (α-D-Gal p A) residues, and a side chain attached to the backbone including β-D-galactan (β-D-Gal p ), α-L-arabinofuranosyl (α-L-Ara f ), or combinations thereof, and a pharmaceutically acceptable excipient. A β-D-Galp side chain is attached to the backbone at the C-4 carbon of at least one α-L-Rhap of the backbone. At least one α-L-Araf is attached to the β-D-Galp side chain. The a-L-Araf is attached to the β-D-Galp side chain via the C-3 carbon of the β-D-Galp. The polysaccharide is effective for treating a galectin-3 dependent disorder by binding to the carbohydrate recognition domain of galectin-3, resulting in inhibition of galectin-3 activity.