公开(公告)号：WO2015160597A1

公开(公告)日：2015-10-22

申请号：PCT/US2015/024965

申请日：2015-04-08

Applicant: TRUSTEES OF BOSTON UNIVERSITY

Inventor： REINHARD, Bjoern Markus ,  GUMMULURU, Suryaram

IPC: A61K9/127 ,  A61B5/055

CPC classification number: A61K9/5123 ,  A61B5/055 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/1272 ,  A61K9/5115 ,  A61K9/5192 ,  A61K47/543 ,  A61K47/61 ,  A61K47/6911 ,  A61K47/6923 ,  A61K47/6929 ,  B82Y5/00 ,  G01N33/5005

Abstract: Embodiments disclosed herein relates to ganglioside GM3-containing mixed lipids nanoparticles having an overall size between 60-100 nm, the making thereof and the uses. The nanoparticles selectively targeted to CD169+ expressing cells such as dendritic cells and macrophage. The nanoparticles are endocytosed by the CD169+ expressing cells.

Abstract translation: 本文公开的实施方案涉及总体尺寸在60-100nm之间的含神经节苷脂GM3的混合脂质纳米颗粒，其制备和用途。 纳米颗粒选择性靶向CD169 +表达细胞，如树突状细胞和巨噬细胞。 纳米颗粒被CD169 +表达细胞内吞。