公开(公告)号：WO2004060912A2

公开(公告)日：2004-07-22

申请号：PCT/US2003/041567

申请日：2003-12-29

Applicant: UAB RESEARCH FOUNDATION ,  COSENZA, Larry

Inventor： COSENZA, Larry

IPC: C07K

CPC classification number: C12N15/86 ,  A61K48/00 ,  C12N15/85 ,  C12N2770/32322 ,  C12N2770/32323 ,  C12N2810/60 ,  C12N2820/55 ,  C12N2820/85 ,  C12N2830/00 ,  C12N2830/15 ,  C12N2830/55 ,  C12N2830/60

Abstract: The present invention encompasses chimeric capsid proteins, nucleic acids encoding such proteins and capsids containing chimeric capsid proteins. Methods of malting the chimeric capsid proteins, the nucleic acids that encode such proteins and capsids that contain chimeric capsid proteins are also encompassed within the scope of the invention. The invention further encompasses the use of the chimeric capsid proteins to produce protein elements and to present the elements for use in structure­-function studies, for use as therapeutic factors and for other purposes. Other embodiments of the invention will be apparent to those skilled in the art from consideration of the specification and practice of the invention disclosed herein. It is intended that the specification and examples be considered as exemplary only.

Abstract translation: 本发明包括嵌合衣壳蛋白，编码这种蛋白质的核酸和含有嵌合衣壳蛋白的衣壳。 编码嵌合衣壳蛋白，编码这种蛋白质的核酸和含有嵌合衣壳蛋白的衣壳的方法也包括在本发明的范围内。 本发明还包括嵌合衣壳蛋白用于产生蛋白质元件并呈现用于结构功能研究的元件，用作治疗因素和用于其它目的的用途。 通过考虑本文公开的本发明的说明书和实践，本发明的其它实施例对于本领域技术人员将是显而易见的。 旨在将说明书和实施例视为仅作为示例。

公开(公告)号：WO2003000855A2

公开(公告)日：2003-01-03

申请号：PCT/US2002/019891

申请日：2002-06-21

Applicant: UAB RESEARCH FOUNDATION ,  COSENZA, Larry

Inventor： COSENZA, Larry

IPC: C12N

CPC classification number: C07K14/005 ,  A61K38/00 ,  C07K2299/00 ,  C07K2319/00 ,  C12N2770/32322 ,  C12N2795/18122

Abstract: The present invention encompasses chimeric capsid proteins, nucleic acids encoding such proteins and capsids containing chimeric capsid proteins. Methods of making the chimeric capsid proteins, the nucleic acids that encode such proteins and capsids that contain chimeric capsid proteins are also encompassed within the scope of the invention. The invention further encompasses the use of the chimeric capsid proteins to produce protein elements and to present the elements for use in structure-function studies, for use as therapeutic factors and for other purposes. Other embodiments of the invention will be apparent to those skilled in the art from consideration of the specification and practice of the invention disclosed herein. It is intended that the specification and examples be considered as exemplary only.

Abstract translation: 本发明包括嵌合衣壳蛋白，编码这种蛋白的核酸和含有嵌合衣壳蛋白的衣壳。 制造嵌合衣壳蛋白的方法，编码这些蛋白的核酸和含有嵌合衣壳蛋白的衣壳也包括在本发明的范围内。 本发明进一步包括使用嵌合衣壳蛋白产生蛋白质元件和呈现用于结构功能研究，用作治疗因子和用于其他目的的元素。 考虑到本文公开的本发明的说明书和实践，本发明的其它实施方案对于本领域技术人员将是显而易见的。 它的目的是说明书和例子仅被视为示例。

公开(公告)号：WO2004011911A2

公开(公告)日：2004-02-05

申请号：PCT/US2003/024083

申请日：2003-07-30

Applicant: UAB RESEARCH FOUNDATION

Inventor： COSENZA, Larry ,  GESTER, Thomas, E. ,  DELUCAS, Lawrence, J. ,  BRAY, Terry, L. ,  HAMRICK, David, T.

IPC: G01N

CPC classification number: G01N33/00 ,  C07K1/306 ,  C30B7/00 ,  C30B29/58 ,  G01N25/147 ,  G01N33/6839

Abstract: An improved method of screening crystal growth conditions is provided wherein molecules are crystallized from solutions containing dyes. These dyes are selectively incorporated or associated with crystals of particular character thereby rendering crystals of particular character colored and improving detection of the dyed crystals. A preferred method involves use of dyes in protein solutions overlayed by oil. Use of oil allows the use of small volumes of solution and facilitates the screening of large numbers of crystallization conditions in arrays using automated devices that dispense appropriate solutions to generate crystallization trials, overlay crystallization trials with an oil, provide appropriate conditions conducive to crystallization and enhance detection of dyed (colored) or undyed (uncolored) crystals that result.

Abstract translation: 提供了一种筛选晶体生长条件的改进方法，其中分子从含有染料的溶液中结晶。 这些染料被选择性地掺入或与具有特定特征的晶体结合，从而使具有特定特征的晶体着色并改善了染色晶体的检测。 优选的方法包括在由油覆盖的蛋白质溶液中使用染料。 油的使用允许使用小体积的溶液，并且有助于使用自动化装置筛选大量结晶条件，分配合适的溶液以产生结晶试验，用油覆盖结晶试验，提供有利于结晶和增强的适当条件 检测染色（有色）或未染色（未着色）晶体。

公开(公告)号：WO2003012430A1

公开(公告)日：2003-02-13

申请号：PCT/US2002/024032

申请日：2002-07-30

Applicant: UAB RESEARCH FOUNDATION

Inventor： COSENZA, Larry ,  BRAY, Terry ,  DELUCAS, Lawrence, J. ,  GESTER, Thomas ,  HAMRICK, David, T.

IPC: G01N31/00

CPC classification number: G01N25/147 ,  C07K1/306 ,  C30B7/00 ,  C30B29/58

Abstract: An improved method of screening crystal growth conditions is provided wherein molecules are crystallized from solutions containing dyes. These dyes are selectively incorporated or associated with crystals of particular character thereby rendering crystals of particular character colored and improving detection of the dyed crystals. A preferred method involves use of dyes in protein solutions overlayed by oil. Use of oil allows the use of small volumes of solution and facilitates the screening of large numbers of crystallization conditions in arrays using automated devices that dispense appropriate solutions to generate crystallization trials, overlay crystallization trials with an oil, provide appropriate conditions conducive to crystallization and enhance detection of dyed (colored) or undyed (uncolored) crystals that result.

Abstract translation: 提供了一种筛选晶体生长条件的改进方法，其中分子从含有染料的溶液中结晶。 这些染料被选择性地掺入或与具有特定特征的晶体结合，从而使具有特定特征的晶体着色并改善了染色晶体的检测。 优选的方法包括在由油覆盖的蛋白质溶液中使用染料。 油的使用允许使用小体积的溶液，并且有助于使用自动化装置筛选大量结晶条件，分配合适的溶液以产生结晶试验，用油覆盖结晶试验，提供有利于结晶和增强的适当条件 检测染色（有色）或未染色（未着色）晶体。