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    CHIMERIC CAPSID PROTEINS AND EXPRESSION VECTORS FOR MONOCISTRONIC EXPRESSION OF MULTIPLE GENES
    3.
    发明申请
    CHIMERIC CAPSID PROTEINS AND EXPRESSION VECTORS FOR MONOCISTRONIC EXPRESSION OF MULTIPLE GENES 审中-公开
    CHMERIC CAPSID蛋白和表达多态性表达载体

    公开(公告)号：WO2004060912A3

    公开(公告)日：2005-05-19

    申请号：PCT/US0341567

    申请日：2003-12-29

    Applicant: UAB RESEARCH FOUNDATION ,  COSENZA LARRY

    Inventor： COSENZA LARRY

    IPC: A61K48/00 ,  C07K20060101 ,  C12N7/01 ,  C12N15/00 ,  C12N15/85 ,  C12N15/861 ,  C12P1/00

    CPC classification number: C12N15/86 ,  A61K48/00 ,  C12N15/85 ,  C12N2770/32322 ,  C12N2770/32323 ,  C12N2810/60 ,  C12N2820/55 ,  C12N2820/85 ,  C12N2830/00 ,  C12N2830/15 ,  C12N2830/55 ,  C12N2830/60

    Abstract: The present invention encompasses chimeric capsid proteins, nucleic acids encoding such proteins and capsids containing chimeric capsid proteins. Methods of malting the chimeric capsid proteins, the nucleic acids that encode such proteins and capsids that contain chimeric capsid proteins are also encompassed within the scope of the invention. The invention further encompasses the use of the chimeric capsid proteins to produce protein elements and to present the elements for use in structure­-function studies, for use as therapeutic factors and for other purposes. Other embodiments of the invention will be apparent to those skilled in the art from consideration of the specification and practice of the invention disclosed herein. It is intended that the specification and examples be considered as exemplary only.

    Abstract translation: 本发明包括嵌合衣壳蛋白，编码这种蛋白质的核酸和含有嵌合衣壳蛋白的衣壳。 编码嵌合衣壳蛋白，编码这种蛋白质的核酸和含有嵌合衣壳蛋白的衣壳的方法也包括在本发明的范围内。 本发明还包括嵌合衣壳蛋白用于产生蛋白质元件并呈现用于结构功能研究的元件，用作治疗因素和用于其它目的的用途。 通过考虑本文公开的本发明的说明书和实践，本发明的其它实施例对于本领域技术人员将是显而易见的。 旨在将说明书和实施例视为仅作为示例。

    A METHOD OF MAKING ADENOVIRUS AND CORRESPONDING PLASMIDS
    4.
    发明申请
    A METHOD OF MAKING ADENOVIRUS AND CORRESPONDING PLASMIDS 审中-公开
    制备腺病毒和相关药物的方法

    公开(公告)号：WO2015097220A1

    公开(公告)日：2015-07-02

    申请号：PCT/EP2014/079162

    申请日：2014-12-23

    Applicant: PSIOXUS THERAPEUTICS LIMITED

    Inventor： BROWN, Alice Claire Noel ,  NICOLSON, Tamara

    IPC: C12N15/86

    CPC classification number: C12N15/86 ,  A61K48/00 ,  C12N7/00 ,  C12N2710/10321 ,  C12N2710/10332 ,  C12N2710/10341 ,  C12N2710/10343 ,  C12N2710/10351 ,  C12N2800/30 ,  C12N2820/55

    Abstract: The present disclosure relates to a method of making an adenovirus plasmid comprising a part or all of an adenovirus genome and one or more original restriction sites allowing rapid and flexible manipulation of the adenovirus genome, and methods of preparing adenovirus constructs, for example comprising a transgene. The disclosure also extends to novel intermediates employed in and generated by the method, to plasmids and shuttle vectors of the method and to adenoviruses or adenoviral vectors obtainable from the plasmid and/or method. The disclosure further relates to use of the viruses or vectors, for example obtained from a method disclosed herein, in therapy, such as use in the treatment of cancer.

    Abstract translation: 本公开涉及一种制备腺病毒质粒的方法，该腺病毒质粒包含一部分或全部腺病毒基因组和一个或多个允许对腺病毒基因组进行快速和灵活操作的原始限制性位点，以及制备腺病毒构建体的方法，例如包含转基因 。 本公开还延伸到本方法中使用并由该方法生成的新中间体，该方法的质粒和穿梭载体以及可从质粒和/或方法获得的腺病毒或腺病毒载体。 本公开还涉及例如从本文公开的方法获得的病毒或载体在治疗中的用途，例如用于治疗癌症。

    CONTROLLING TRANSGENE EXPRESSION ACROSS THE SKIN
    7.
    发明申请
    CONTROLLING TRANSGENE EXPRESSION ACROSS THE SKIN 审中-公开
    控制皮肤的转运表达

    公开(公告)号：WO2010115583A1

    公开(公告)日：2010-10-14

    申请号：PCT/EP2010/002103

    申请日：2010-04-01

    Applicant: ETH ZURICH ,  FUSSENEGGER, Martin ,  GITZINGER, Marc

    Inventor： FUSSENEGGER, Martin ,  GITZINGER, Marc

    IPC: C12N15/09

    CPC classification number: C12N15/8509 ,  A61K9/0014 ,  A61K47/10 ,  C12N2820/55 ,  C12N2830/002 ,  C12N2830/005

    Abstract: The invention relates to the use of a skin permeating compound such as phloretin for controlling transgene expression under control of the Pseudomonas putida DOT-T1E- derived bacterial repressor TtgR, to a vector comprising the genetic code for the repressor TtgR fused to a transactivation or a transrepressor domain, to a vector comprising a TtgR- specific operator sequence (O TtgR ), a promoter and a polynucleotide coding for an endogenous or exogenous protein, and to a mammalian cell transiently or constitutively transfected with the mentioned vectors, and to mammals comprising such cells in nano- or microcontainers.

    Abstract translation: 本发明涉及皮肤渗透化合物如延胡索素用于在恶臭假单胞菌DOT-T1E衍生的细菌阻遏物TtgR的控制下控制转基因表达的用途，所述载体包含与转录激活融合的阻遏物TtgR的遗传密码 反义阻抑物结构域，包含TtgR特异性操纵子序列（OTtgR），启动子和编码内源或外源蛋白的多核苷酸的载体，以及用所述载体瞬时或组成型转染的哺乳动物细胞，以及包含该细胞的哺乳动物 在纳米或微型容器中。

    METHODS AND MATERIALS FOR EXPRESSION OF A RECOMBINANT PROTEIN
    8.
    发明申请
    METHODS AND MATERIALS FOR EXPRESSION OF A RECOMBINANT PROTEIN 审中-公开
    表达重组蛋白的方法和材料

    公开(公告)号：WO2006060769A3

    公开(公告)日：2007-02-15

    申请号：PCT/US2005043922

    申请日：2005-12-05

    Applicant: XOMA TECHNOLOGY LTD ,  HANDA MASAHISA ,  HORWITZ ARNOLD ,  BAUTISTA EDDIE ,  COTTER ROBYN

    Inventor： HANDA MASAHISA ,  HORWITZ ARNOLD ,  BAUTISTA EDDIE ,  COTTER ROBYN

    IPC: C12N15/869 ,  C12N5/00 ,  C12N15/67

    CPC classification number: C07K16/00 ,  C12N7/00 ,  C12N15/85 ,  C12N2710/16221 ,  C12N2710/16243 ,  C12N2800/108 ,  C12N2820/10 ,  C12N2820/55 ,  C12N2820/60 ,  C12N2830/42

    Abstract: Recombinant expression vectors are provided comprising a 3' UTR of a light chain and an Epstein-Barr virus origin of replication. Also provided are host cells comprising such vectors and methods of producing recombinant protein with such vectors. Additional methods of producing a recombinant protein involve contacting cells with a first and second vector, each of which encode a different polypeptide chain, and wherein the second vector is present in an amount which is about 1.5 to 2.5 times as much as that of the first vector. Cells also can be transfected with a recombinant transient expression vector encoding a protein and are cultured in a medium in a membrane-enhanced culturing vessel to produce recombinant protein.

    Abstract translation: 提供重组表达载体，其包含轻链的3'UTR和Epstein-Barr病毒复制起点。 还提供了包含这种载体的宿主细胞和用这种载体产生重组蛋白的方法。 生产重组蛋白质的其它方法包括使细胞与第一和第二载体接触，第一和第二载体各自编码不同的多肽链，其中第二载体的存在量为第一载体的约1.5至2.5倍 向量。 细胞也可以用编码蛋白质的重组瞬时表达载体转染，并在膜增强培养容器中的培养基中培养以产生重组蛋白。

    METHODS AND MATERIALS FOR EXPRESSION OF A RECOMBINANT PROTEIN
    9.
    发明申请
    METHODS AND MATERIALS FOR EXPRESSION OF A RECOMBINANT PROTEIN 审中-公开
    表达重组蛋白的方法和材料

    公开(公告)号：WO2006060769A2

    公开(公告)日：2006-06-08

    申请号：PCT/US2005/043922

    申请日：2005-12-05

    Applicant: XOMA TECHNOLOGY LTD. ,  HANDA, Masahisa ,  HORWITZ, Arnold ,  BAUTISTA, Eddie ,  COTTER, Robyn

    Inventor： HANDA, Masahisa ,  HORWITZ, Arnold ,  BAUTISTA, Eddie ,  COTTER, Robyn

    CPC classification number: C07K16/00 ,  C12N7/00 ,  C12N15/85 ,  C12N2710/16221 ,  C12N2710/16243 ,  C12N2800/108 ,  C12N2820/10 ,  C12N2820/55 ,  C12N2820/60 ,  C12N2830/42

    Abstract: Recombinant expression vectors are provided comprising a 3' UTR of a light chain and an Epstein-Barr virus origin of replication. Also provided are host cells comprising such vectors and methods of producing recombinant protein with such vectors. Additional methods of producing a recombinant protein involve contacting cells with a first and second vector, each of which encode a different polypeptide chain, and wherein the second vector is present in an amount which is about 1.5 to 2.5 times as much as that of the first vector. Cells also can be transfected with a recombinant transient expression vector encoding a protein and are cultured in a medium in a membrane-enhanced culturing vessel to produce recombinant protein.

    Abstract translation: 提供重组表达载体，其包含轻链的3'UTR和Epstein-Barr病毒复制起点。 还提供了包含这种载体的宿主细胞和用这种载体产生重组蛋白的方法。 生产重组蛋白质的其它方法包括使细胞与第一和第二载体接触，第一和第二载体各自编码不同的多肽链，其中第二载体的存在量为第一载体的约1.5至2.5倍 向量。 细胞也可以用编码蛋白质的重组瞬时表达载体转染，并在膜增强培养容器中的培养基中培养以产生重组蛋白。

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