公开(公告)号：WO2020052994A1

公开(公告)日：2020-03-19

申请号：PCT/EP2019/073193

申请日：2019-08-30

申请人： UNILEVER N.V. ,  UNILEVER PLC ,  CONOPCO, INC., D/B/A UNILEVER

发明人： DONG, Yiying ,  HUANG, Dandan ,  HUANG, Nan ,  MI, Tingyan

IPC分类号： G01N33/50

摘要： Disclosed is an in vitro method to determine efficacy of a cosmetic ingredient against stressors, said method comprising the steps of: (i) contacting a 3D living skin-equivalent (LSE) comprising primary human keratinocytes with an oxidative environmental stressor for a pre-determined period; (ii) measuring, by any known means, the extent to which barrier function of said LSE is affected; (iii) determining the number of viable keratinocytes; (iv) contacting said LSE with said cosmetic ingredient; (v) repeating said steps (ii) and (iii); and, (vi) inferring that said ingredient is efficacious if there is improvement in cell viability and barrier function, where said step (iv) is alternatively carried out along with or prior to said step (i), wherein said living LSE is contacted with a non-environmental stressor for a pre-determined period, before step (i) or between said steps (i) and (ii) and further wherein the extent to which said barrier function is affected is measured by permeability assay using a dye.

公开(公告)号：WO2018041544A1

公开(公告)日：2018-03-08

申请号：PCT/EP2017/069920

申请日：2017-08-07

申请人： UNILEVER N.V. ,  UNILEVER PLC ,  CONOPCO, INC., D/B/A UNILEVER

发明人： CHEN, Yu ,  HARDING, Clive, Roderick ,  HARICHIAN, Bijan ,  HUANG, Dandan ,  ROSA, Jose, Guillermo ,  ZHOU, Luxian

IPC分类号： A61K8/34 ,  A61K8/67 ,  A61Q11/00 ,  A61Q19/00 ,  A61P17/00

摘要： The invention relates to a personal care composition that is primarily directed to prevent or reduce inflammation in topical cells. It could be delivered in the form of an oral care, hair/scalp care or skin care composition and comprises gingerdiol in combination with a vitamin B3 compound.

摘要翻译： 本发明涉及主要旨在预防或减轻局部细胞炎症的个人护理组合物。 它可以以口腔护理，头发/头皮护理或皮肤护理组合物的形式递送，并且包含姜二醇与维生素B3化合物的组合。

公开(公告)号：WO2021099117A1

公开(公告)日：2021-05-27

申请号：PCT/EP2020/080918

申请日：2020-11-04

申请人： UNILEVER IP HOLDINGS B.V. ,  UNILEVER GLOBAL IP LIMITED ,  CONOPCO, INC., D/B/A UNILEVER

发明人： GU, Xuelan ,  HUANG, Dandan

IPC分类号： A61K8/9789 ,  A61K8/04 ,  A61K8/49 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q19/00 ,  A61Q5/00

摘要： This invention relates to a cosmetic composition, especially one which provides synergistic anti-dandruff efficacy. This is achieved through a judicious combination of anti-dandruff agent piroctone olamine and a willow bark extract. Disclosed is a cosmetic composition comprising: (i) piroctone olamine; (ii) a willow bark extract; and (iii) a cosmetically acceptable carrier, wherein the ratio of the amount of said willow bark extract to that of said piroctone olamine is at least 1:2 parts by weight; wherein said willow bark extract is extracted from salix alba, salix glandulosa, salix purpurea or salix caroliniana.

公开(公告)号：WO2022135882A1

公开(公告)日：2022-06-30

申请号：PCT/EP2021/084300

申请日：2021-12-06

申请人： UNILEVER IP HOLDINGS B.V. ,  UNILEVER GLOBAL IP LIMITED ,  CONOPCO, INC., D/B/A UNILEVER

发明人： GU, Xuelan ,  HUANG, Dandan ,  ZHANG, Hong

IPC分类号： A61K8/9789 ,  A61K8/365 ,  A61Q19/08 ,  A61P17/10 ,  A61P29/00 ,  A61K36/31

摘要： Disclosed is a personal care composition providing anti-inflammation benefits. The composition comprises a moringa extract and a hydroxy fatty acid, wherein the weightratio of the moringa extract to the hydroxy fatty acid is from 1:1 to 75:1.

公开(公告)号：WO2021089306A1

公开(公告)日：2021-05-14

申请号：PCT/EP2020/079327

申请日：2020-10-19

申请人： UNILEVER IP HOLDINGS B.V. ,  UNILEVER GLOBAL IP LIMITED ,  CONOPCO, INC., D/B/A UNILEVER

发明人： GU, Xuelan ,  HUANG, Dandan

IPC分类号： A61K8/49 ,  A61K8/67 ,  A61P29/00 ,  A61Q5/00

摘要： This invention relates to a cosmetic composition, especially one which provides synergistic anti-dandruff efficacy. This is achieved through a judicious combination of anti-dandruff agent piroctone olamine and a vitamin B3 compound. Disclosed is an anti-inflammatory composition comprising: (i) piroctone olamine; (ii) a vitamin B3 compound; and (iii) a cosmetically acceptable carrier, wherein the ratio of the amount of said vitamin B3 compound to that of said piroctone olamine is at least 22:1 part by weight; wherein said vitamin B3 is niacinamide.