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    POLLUTION PROTECTION FACTOR OF COSMETIC COMPOSITIONS
    1.
    发明申请
    POLLUTION PROTECTION FACTOR OF COSMETIC COMPOSITIONS 审中-公开

    公开(公告)号：WO2020200936A1

    公开(公告)日：2020-10-08

    申请号：PCT/EP2020/058246

    申请日：2020-03-25

    申请人： UNILEVER N.V. ,  UNILEVER PLC ,  CONOPCO, INC., D/B/A UNILEVER

    发明人： DOBKOWSKI, Brian, John ,  HUANG, Nan ,  MENG, Sheng

    IPC分类号： A61B5/00 ,  A61K8/00 ,  A61Q17/00

    摘要： Disclosed is a method of determination of a pollution protection factor (PPF) of a cosmetic composition, comprising: (a) a step of testing, by any known test method, the ability (α) of the cosmetic composition to render ineffective at least one type of pollutant present on the skin and expressing it on a scale of 0 to 1, followed by calculating said PPF by equation A, where (1 - α) indicates corresponding potential residual damage to the skin wherein said composition comprises at least one ingredient known to render ineffective said at least one type of pollutant and said at least one ingredient is an anti-inflammatory or antioxidant; or alternatively, (b) a step of testing, by any known test method, the ability (β) of the cosmetic composition to inhibit the contact of at least one type of pollutant with skin and expressing it also on a scale of 0 to 1, followed by calculating said PPF by equation B, where (1 - β) indicates corresponding potential residual damage to the skin wherein said composition comprises at least one ingredient known to inhibit the contact of at least one type of pollutant with skin and wherein said ingredient is a sunscreen, a barrier enhancer or a polymer; or further alternatively, (c) a step of testing, by any known test method, the ability (γ) of the cosmetic composition to remove at least one type of pollutant present on the skin, expressing it also on a scale of 0 to 1, followed by calculating said PPF by equation C, where (1 - γ) indicates corresponding potential residual damage to the skin.

    METHOD OF EVALUATING EFFICACY OF COSMETIC COMPOSITIONS
    2.
    发明申请
    METHOD OF EVALUATING EFFICACY OF COSMETIC COMPOSITIONS 审中-公开

    公开(公告)号：WO2020052994A1

    公开(公告)日：2020-03-19

    申请号：PCT/EP2019/073193

    申请日：2019-08-30

    申请人： UNILEVER N.V. ,  UNILEVER PLC ,  CONOPCO, INC., D/B/A UNILEVER

    发明人： DONG, Yiying ,  HUANG, Dandan ,  HUANG, Nan ,  MI, Tingyan

    IPC分类号： G01N33/50

    摘要： Disclosed is an in vitro method to determine efficacy of a cosmetic ingredient against stressors, said method comprising the steps of: (i) contacting a 3D living skin-equivalent (LSE) comprising primary human keratinocytes with an oxidative environmental stressor for a pre-determined period; (ii) measuring, by any known means, the extent to which barrier function of said LSE is affected; (iii) determining the number of viable keratinocytes; (iv) contacting said LSE with said cosmetic ingredient; (v) repeating said steps (ii) and (iii); and, (vi) inferring that said ingredient is efficacious if there is improvement in cell viability and barrier function, where said step (iv) is alternatively carried out along with or prior to said step (i), wherein said living LSE is contacted with a non-environmental stressor for a pre-determined period, before step (i) or between said steps (i) and (ii) and further wherein the extent to which said barrier function is affected is measured by permeability assay using a dye.

    EVALUATING THE EFFICACY OF LEAVE-ON COSMETIC COMPOSITIONS TO PROTECT FROM POLLUTANTS
    4.
    发明申请
    EVALUATING THE EFFICACY OF LEAVE-ON COSMETIC COMPOSITIONS TO PROTECT FROM POLLUTANTS 审中-公开

    公开(公告)号：WO2019219393A1

    公开(公告)日：2019-11-21

    申请号：PCT/EP2019/061200

    申请日：2019-05-02

    申请人： UNILEVER N.V. ,  UNILEVER PLC ,  CONOPCO, INC., D/B/A UNILEVER

    发明人： CHEN, Guoqiang ,  FANG, Yi ,  HUANG, Nan ,  JI, Chengdong ,  MENG, Sheng ,  YI, Shangchun ,  YUAN, Caigen

    IPC分类号： G01N15/04 ,  G01N21/62

    摘要： Disclosed is an in vitro method to determine efficacy of a cosmetic composition or an active ingredient comprised therein to inhibit an atmospheric pollutant from contacting skin, comprising the steps of: (i) filling a sample holder of known dimensions with a known amount of said composition to form a layer of defined thickness therein; (ii) depositing, on said layer, a known amount of a model fine particulate matter which resembles a particulate atmospheric pollutant and is responsive to a spectroscopic or microscopic chemical imaging technique; (iii) performing said chemical imaging; (iv) for a defined period, recording and analyzing the interaction of said model fine particulate matter with and within said layer by the imaging technique, where interaction indicates the penetration speed of said model fine particulate matter in the layer; and, (v) ascertaining said efficacy from the information of step (iv) wherein the slope of a plot of data obtained from said imaging technique against time in the range of 1 to 100 minutes is indicative of short-term efficacy of said composition and the nature of the plot beyond 100 minutes is indicative of long- term efficacy and wherein long-term inhibition factor of said composition is calculated as follows: Long term inhibition factor = Formula (1) where, x is the distance between the bottom of the chamber and the assumed centre of the Gaussian distribution of the model fine particulate model in the layer, σ is the width of the Gaussian distribution and μ is the mean of the Gaussian distribution, where it is assumed that distribution of the model fine particulate matter in said layer follows Gaussian distribution.

    A PERSONAL CARE COMPOSITION
    7.
    发明申请
    A PERSONAL CARE COMPOSITION 审中-公开

    公开(公告)号：WO2019042685A1

    公开(公告)日：2019-03-07

    申请号：PCT/EP2018/070746

    申请日：2018-07-31

    申请人： UNILEVER N.V. ,  UNILEVER PLC ,  CONOPCO, INC., D/B/A UNILEVER

    发明人： GUO, Chenliang ,  HUANG, Nan ,  ROCHA, Sheila, Alves

    IPC分类号： A61K8/36 ,  A61K8/37 ,  A61K8/49 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q19/00 ,  A61K8/9783 ,  A61K31/202 ,  A61K31/36

    摘要： The invention relates to a personal care composition, more particularly to a composition for application to a topical surface that prevents or reduces inflammation. The composition could be delivered in the form of a skin, scalp, hair or oral care product, more particularly a skin care product. The benefit is delivered via a combination of a polyunsaturated fatty acid (PUFA) or ester thereof selected from docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), DHA-ethyl ester, EPA-ethyl ester, DHA-triglyceride, EPA-triglyceride, dihomogamma-linolenic acid (DGLA), DGLA-ethyl ester (DGLA-EE), DGLA-triglyceride or combinations thereof and a lignan compound extractable from sesame selected from sesamin, sesamol, episesamin, sesaminol, episesaminol, sesamolin or combinations thereof.

    METHOD OF EVALUATING EFFICACY OF COSMETIC CLEANSING COMPOSITIONS
    10.
    发明申请
    METHOD OF EVALUATING EFFICACY OF COSMETIC CLEANSING COMPOSITIONS 审中-公开

    公开(公告)号：WO2019219390A1

    公开(公告)日：2019-11-21

    申请号：PCT/EP2019/061186

    申请日：2019-05-02

    申请人： UNILEVER N.V. ,  UNILEVER PLC ,  CONOPCO, INC., D/B/A UNILEVER

    发明人： CHEN, Guoqiang ,  HUANG, Nan ,  JI, Chengdong ,  MENG, Sheng

    IPC分类号： A61B5/00 ,  G01N33/50 ,  G06T7/00 ,  G01N21/00 ,  G01N21/64

    摘要： Disclosed is an in vitro method to determine efficacy of a cosmetic cleansing composition or an active ingredient comprised therein to remove particulate pollutants adhering to the skin, comprising the steps of: (i) contacting a human skin-equivalent with a model fine particulate matter resembling a particulate atmospheric pollutant and measuring a first concentration of said model fine particulate matter on said human skin equivalent by an imaging technique; (ii) cleansing said human skin equivalent bearing said model fine particulate matter thereon with said cosmetic cleansing composition and measuring a second concentration of said model fine particulate matter on said human skin equivalent by the imaging technique; (iii) differentiating between said first and said second concentration; and, (iv) ascertaining said efficacy from the information of step (iii), wherein, said technique is a spectroscopic or microscopic chemical imaging technique, where said chemical imaging does not mean or include colorimetric or digital image analysis and wherein said human skin equivalent is artificial skin, donor skin, living skin equivalent or pig skin and wherein said model fine particulate matter is in the form of beads comprising polystyrene and a fluorescent material, further wherein said microscopic imaging technique is fluorescence microscopy and said human skin- equivalent is artificial skin.