公开(公告)号：WO2013039956A3

公开(公告)日：2014-05-15

申请号：PCT/US2012054735

申请日：2012-09-12

Applicant: UNIV COLUMBIA ,  SCHMAUSS CLAUDIA ,  LEVINE AMIR

Inventor： SCHMAUSS CLAUDIA ,  LEVINE AMIR

IPC: A61K38/00 ,  A61P3/04 ,  A61P25/00

CPC classification number: A61K31/167 ,  A61K31/138 ,  A61K31/19 ,  A61K31/20 ,  A61K31/4406 ,  A61K45/06 ,  C12Q1/34 ,  G01N2800/304 ,  G01N2800/52 ,  A61K2300/00

Abstract: The present invention provides, inter alia, methods for enhancing the anti-depressant efficacy of a selective serotonin re-uptake inhibitor (SSRI) in a patient being treated for a mood disorder. These methods include administering to a patient in need thereof a therapeutically effective amount of an SSRI and a therapeutically effective amount of a modulator of histone expression. Also provided are methods for identifying a patient population that suffers from a mood disorder that is more likely to respond to SSRI treatment. Further provided are compositions for treating or ameliorating the effects of a mood disorder.

Abstract translation: 本发明尤其提供了用于增加选择性5-羟色胺再吸收抑制剂（SSRI）在治疗情绪障碍的患者中的抗抑郁功效的方法。 这些方法包括向有需要的患者施用治疗有效量的SSRI和治疗有效量的组蛋白表达调节剂。 还提供了用于鉴定患有更可能对SSRI治疗作出反应的情绪障碍的患者群体的方法。 还提供了用于治疗或改善情绪障碍的作用的组合物。