公开(公告)号：WO2015168286A8

公开(公告)日：2016-11-17

申请号：PCT/US2015028293

申请日：2015-04-29

申请人： UNIV COLUMBIA ,  PETRUKHIN KONSTANTIN ,  ALLIKMETS RANDO ,  JOHNSON GRAHAM ,  CIOFFI CHRISTOPHER ,  FREEMAN EMILY ,  CHEN PING ,  CONLON MICHAEL ,  ZHU LEI

发明人： PETRUKHIN KONSTANTIN ,  ALLIKMETS RANDO ,  JOHNSON GRAHAM ,  CIOFFI CHRISTOPHER ,  FREEMAN EMILY ,  CHEN PING ,  CONLON MICHAEL ,  ZHU LEI

IPC分类号： A61P27/02 ,  A61K31/445 ,  A61K31/451

CPC分类号： C07D487/04 ,  C07D471/04

摘要： The present invention provides a compound having the structure: wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl, wherein two or more of R1, R2, R3, R4, or R5 are other than H; R6 is H, OH, or halogen; and B is a substituted or unsubstituted heterobicycle, wherein when R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is H, R2 is CF3, R3 is H, R4 is CF3, and R5 is H, or R1 is C1, R2 is H, R3 is H, R4 is F, and R5 is H, or R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is CF3, R2 is F, R3 is H, R4 is H, and R5 is H, or R1 is C1, R2 is F, R3 is H, R4 is H, and R5 is H, then B is other than or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明提供具有以下结构的化合物：其中R 1，R 2，R 3，R 4和R 5各自独立地为H，卤素，CF 3或C 1 -C 4烷基，其中R 1，R 2，R 3，R 4或R 5中的两个或多个 不是H; R6是H，OH或卤素; B是取代或未取代的杂双环，其中当R1是CF3时，R2是H，R3是F，R4是H，R5是H，或R1是H，R2是CF3，R3是H，R4是CF3， R5是H，或R1是C1，R2是H，R3是H，R4是F，R5是H，或R1是CF3，R2是H，R3是F，R4是H，R5是H，或R1 是CF 3，R 2是F，R 3是H，R 4是H，R 5是H或R 1是C，R 2是F，R 3是H，R 4是H，且R 5是H， 其可接受的盐。

公开(公告)号：WO2016061210A3

公开(公告)日：2016-05-12

申请号：PCT/US2015055510

申请日：2015-10-14

申请人： UNIV COLUMBIA

发明人： LIPKIN W IAN ,  KAPOOR AMIT ,  BHAT MEERA ,  FIRTH CADHLA ,  QUAN PHENIX-LAN

IPC分类号： A61K31/351 ,  A61K31/495 ,  A61K31/4965

CPC分类号： C12N7/00 ,  C07K14/005 ,  C12N2770/24221 ,  C12N2770/24222 ,  C12Q1/701

摘要： The invention is directed to novel hepatotropic hepaciviruses isolated in Norway rats (Rattus norvegicus), designated NrHV-1 or RHV-rn-NY01 and NrHV-2 or RHV-rn-NY02, and isolated nucleic acids sequences and polypeptides thereof. The invention also relates to antibodies against antigens from NrHV- 1 or NrHV-2 found in Rattus norvegicus. The invention also relates to iRNAs which target nucleic acid sequences of NrHV- 1 or NrHV-2 found in Rattus norvegicus. The invention is related to methods for detecting the presence or absence of NrHV-1 or NrHV-2 found in Rattus norvegicus in an animal. The invention is also related to immunogenic compositions for inducing an immune response against NrHV-1 or NrHV-2 in an animal. The invention is also related to a cell culture system and a laboratory animal to model human hepatitis C virus (HCV).

摘要翻译： 本发明涉及在称为NrHV-1或RHV-rn-NY01和NrHV-2或RHV-rn-NY02的挪威大鼠（褐家鼠）中分离的新型嗜肝性肝炎病毒，以及分离的核酸序列和其多肽。 本发明还涉及在褐家鼠中发现的抗NrHV-1或NrHV-2抗原的抗体。 本发明还涉及靶向在褐家鼠中发现的NrHV-1或NrHV-2的核酸序列的iRNA。 本发明涉及检测动物中褐家鼠中存在或不存在NrHV-1或NrHV-2的方法。 本发明还涉及用于在动物中诱导针对NrHV-1或NrHV-2的免疫应答的免疫原性组合物。 本发明还涉及用于模拟人丙型肝炎病毒（HCV）的细胞培养系统和实验动物。

公开(公告)号：WO2014075108A3

公开(公告)日：2015-08-20

申请号：PCT/US2013069762

申请日：2013-11-12

申请人： UNIV COLUMBIA

发明人： ANDERSON ROGER N ,  BOULANGER ALBERT ,  WU LEON L ,  BHANDARI VIABHAV ,  SARKER SOMNATH ,  GAGNEJA ASHISH

IPC分类号： G06N5/02

CPC分类号： G06Q10/06315 ,  G06N5/04 ,  G06N7/005 ,  G06N99/005 ,  G06Q10/0631 ,  G06Q10/067 ,  G06Q10/08

摘要： Techniques for determining forecast information for a resource using learning algorithms are disclosed. The techniques can include an ensemble of machine learning algorithms. The techniques can also use latent states to generate training data. The techniques can identify actions for managing the resource based on the forecast information. The resource can include energy usage in buildings, distribution facilities, and resources such as Electric Delivery Vehicles. The resource can also include forecasting package volume for businesses.

摘要翻译： 公开了使用学习算法确定资源的预测信息的技术。 这些技术可以包括机器学习算法的集合。 这些技术还可以使用潜在的状态来生成训练数据。 这些技术可以根据预测信息识别用于管理资源的动作。 该资源可以包括建筑物的能源使用，配电设施以及电动车辆等资源。 该资源还可以包括为企业预测包量。

公开(公告)号：WO2014153168A3

公开(公告)日：2015-02-12

申请号：PCT/US2014029394

申请日：2014-03-14

申请人： UNIV COLUMBIA ,  UNIV IOWA STATE RES FOUND INC ,  UNIV KANSAS STATE ,  ZOETIS LLC

发明人： LIPKIN W IAN ,  FIRTH CADHLA ,  HESSE RICHARD A ,  HARDHAM JOHN MORGAN ,  REDDY SUDHIR KEESARA ,  OPRIESSNIG TANJA I ,  HALBUR PATRICK G ,  MARX JACQUELINE GAYLE

IPC分类号： A61K39/12

CPC分类号： A61K39/12 ,  A61K2039/5252 ,  A61K2039/552 ,  C12N2770/12011 ,  C12N2770/12034

摘要： The invention is directed to isolated porcine astroviruses associated with porcine periweaning failure to thrive syndrome, high morbidity and mortality syndrome in growing pigs, mulberry heart disease, porcine respiratory disease, porcine gastrointestinal disease, or reproductive failure. The invention also relates to isolated nucleic acids sequences and polypeptides derived from porcine astroviruses. Additionally, the invention relates to antibodies against antigens from porcine astroviruses. The invention also relates to iRNAs which target nucleic acid sequences of the porcine astrovirus. The invention is further related to methods for detecting the presence or absence of porcine astroviruses in an animal. The invention is also related to immunogenic compositions for inducing an immune response against porcine astroviruses in an animal.

摘要翻译： 本发明涉及分离的猪星状病毒，所述分离的猪星状病毒与猪周期性失败以促进综合症，生长猪，桑树心脏病，猪呼吸道疾病，猪胃肠疾病或生殖障碍中的高发病率和死亡综合症有关。 本发明还涉及分离的核酸序列和源自猪星状病毒的多肽。 此外，本发明涉及针对来自猪星状病毒的抗原的抗体。 本发明还涉及靶向猪星状病毒的核酸序列的iRNA。 本发明进一步涉及用于检测动物中存在或不存在猪星状病毒的方法。 本发明还涉及用于在动物中诱导针对猪星状病毒的免疫应答的免疫原性组合物。

公开(公告)号：WO2014160804A3

公开(公告)日：2014-12-04

申请号：PCT/US2014031911

申请日：2014-03-26

申请人： UNIV COLUMBIA

发明人： SIA SAMUEL K ,  TEJAVIBULYA NALIN

IPC分类号： A61B5/15 ,  G01N1/10

CPC分类号： A61B5/150984 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/14865 ,  A61B5/15003 ,  A61B5/150099 ,  A61B5/150229 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/15087 ,  A61B5/15123 ,  A61B5/1513 ,  A61B5/15153 ,  A61B5/15163 ,  A61B5/489 ,  A61B5/6831 ,  A61B5/685 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0061

摘要： Devices systems and methods for fluid extraction and delivery to human or animal hosts are described. In embodiments, microneedles are employed to provide low infection risk and painless access to and administration of fluids. The disclosed embodiments address, among others, issues of cost, portability, ease of use in remote settings including use by untrained personnel, and others.

摘要翻译： 描述了用于流体提取和递送到人或动物宿主的装置系统和方法。 在实施方案中，使用微针提供低感染风险并且无痛地进入和施用流体。 所公开的实施例尤其涉及成本，便携性，在远程设置中的易用性，包括未经培训的人员等的使用的问题。

公开(公告)号：WO2014171992A2

公开(公告)日：2014-10-23

申请号：PCT/US2014013892

申请日：2014-01-30

申请人： UNIV COLUMBIA

发明人： YU NANFANG

IPC分类号： H01Q1/38

CPC分类号： H01Q1/38 ,  H01Q21/0087 ,  H01Q21/064

摘要： Exemplary embodiment can utilize the properties of tunable thin-film, material (e.g., graphene) to efficiently modulate the intensity, phase, and/or polarization of transmitted and/or reflected radiation, including mid-infrared ("mid-IR") radiation. Exemplary embodiments include planar antennas comprising tunable thin-film material sections and metallic sections disposed in contact with the tunable thin-film material sections, each metallic section having a gap with at least one dimension related to a wavelength of the radiation, which in some embodiments may be less than the wavelength. The metallic layer may comprise rods arrange in one or more shapes, or one or more apertures of one or more shapes. Embodiments of the antenna may also comprise a substrate, which may be a semiconductor or conductor in various embodiments. Embodiments also include systems, computer-implemented methods, devices, and computer-readable media for effectuating desired modulation of incident radiation by, e.g., varying the doping level of the tunable thin-film material.

摘要翻译： 示例性实施例可以利用可调谐薄膜，材料（例如，石墨烯）的特性来有效地调制包括中红外（“中红外”）辐射的透射和/或反射辐射的强度，相位和/或极化 。 示例性实施例包括包括可调谐薄膜材料部分和与可调谐薄膜材料部分接触设置的金属部分的平面天线，每个金属部分具有与辐射波长有关的至少一个维度的间隙，在一些实施例中 可能小于波长。 金属层可以包括以一种或多种形状布置的杆，或一个或多个形状的一个或多个孔。 在各种实施例中，天线的实施例还可以包括衬底，其可以是半导体或导体。 实施例还包括用于通过例如改变可调谐薄膜材料的掺杂水平来实现对入射辐射的期望调制的系统，计算机实现的方法，设备和计算机可读介质。

公开(公告)号：WO2014116828A3

公开(公告)日：2014-09-25

申请号：PCT/US2014012753

申请日：2014-01-23

申请人： UNIV COLUMBIA

发明人： PADMARAJU KISHORE ,  BERGMAN KEREN

IPC分类号： H01S3/10

CPC分类号： G02F1/0147 ,  G02F1/0121 ,  G02F1/3132 ,  G02F2201/58 ,  H01S3/0085 ,  H01S5/042 ,  H01S5/06832 ,  H01S5/06837 ,  H01S5/0687 ,  H01S5/1032 ,  H01S5/142

摘要： A low-cost, robust method for automatically tuning a coupled resonator to match a wavelength of electromagnetic radiation emitted from an applied laser source. Dithering signals are used for automatic wavelength tuning and thermal stabilization of microring resonators. The disclosed method can be applied using low-speed analog and digital circuitry, to create a complete photonic interconnection network. The methods disclosed also automatically detect, measure, and correct for resonance shift.

摘要翻译： 一种用于自动调谐耦合谐振器以匹配从施加的激光源发射的电磁辐射的波长的低成本，鲁棒的方法。 抖动信号用于微环谐振器的自动波长调谐和热稳定。 所公开的方法可以使用低速模拟和数字电路来应用，以创建完整的光子互连网络。 所公开的方法还自动检测，测量和校正谐振偏移。

公开(公告)号：WO2014145749A1

公开(公告)日：2014-09-18

申请号：PCT/US2014030563

申请日：2014-03-17

申请人： BRIGHAM & WOMENS HOSPITAL ,  MASSACHUSETTS INST TECHNOLOGY ,  UNIV COLUMBIA

发明人： FAROKHAZAD OMID C ,  ZHANG XUEQING ,  XU XIAOYANG ,  KAMALY NAZILA ,  MA MINGMING ,  VALENCIA PEDRO M ,  LANGER ROBERT S ,  TABAS IRA ,  FREDMAN GABRIELLE BETH

IPC分类号： A61K9/14 ,  A61P29/00 ,  A61P37/00

CPC分类号： A61K47/48915 ,  A61K9/5153 ,  A61K31/195 ,  A61K38/16 ,  A61K47/48053 ,  A61K47/48215 ,  A61K47/48246 ,  A61K47/544 ,  A61K47/593 ,  A61K47/60 ,  A61K47/64 ,  A61K47/6937

摘要： Sub- 100 micron multimodal nanoparticles have four main components: 1) a target element (peptides, lipids, antibodies, small molecules, etc.) that can selectively bind to cells, tissues, or organs of the body; 2) a diagnostic agent such as a fiuorophore or NMR contrast agent that allows visualization of nanoparticles at the site of delivery and/or a therapeutic or prophylactic agent; 3) an outside "stealth" layer that allows the particles to evade recognition by immune system components and increase particle circulation half-life; and 4) a biodegradable polymeric material, forming an inner core which can carry therapeutics and release the payloads at a sustained rate after systemic, intraperitoneal, or mucosal administration. These particles possess excellent stability, high loading efficiency, multiple agent encapsulation, targeting and imaging. They are targeted to sites of, or associated with, inflammation caused by a disease, disorder; trauma, chemotherapy or radiation.

摘要翻译： 亚100微米多模式纳米粒子具有四个主要组分：1）可以选择性结合至身体的细胞，组织或器官的靶元件（肽，脂质，抗体，小分子等）; 2）诊断剂，例如允许在递送部位和/或治疗剂或预防剂上观察纳米颗粒的荧光团或NMR造影剂; 3）允许颗粒逃避免疫系统成分识别并增加颗粒循环半衰期的外部“隐形”层; 和4）可生物降解的聚合物材料，形成内核，其可以在全身，腹膜内或粘膜给药后以持续的速率携带治疗剂并释放有效负荷。 这些颗粒具有优异的稳定性，高负载效率，多药物包封，靶向和成像。 它们针对由疾病，病症引起的炎症部位或与其相关的部位; 创伤，化疗或放疗。

公开(公告)号：WO2014127003A2

公开(公告)日：2014-08-21

申请号：PCT/US2014016028

申请日：2014-02-12

申请人： UNIV COLUMBIA

发明人： OKA YUKI ,  ZUKER CHARLES

IPC分类号： A23L27/40 ,  A23L27/10

CPC分类号： A23L1/22091 ,  A23L27/40 ,  A23L27/45 ,  A23L27/88 ,  A23V2002/00 ,  C07C331/22 ,  C07D285/135 ,  C07D495/04 ,  G01N33/5088

摘要： The current invention is in the field of taste and relates to methods and compositions to modulate the perceived taste of saltiness in food or food products where salty taste is desired. The methods and compositions relate to altering the activation and/or activity of the bitter- sensing taste receptor cells and the PKD2L1 -expressing taste receptor cells. The invention also relates to food and food products containing agents and composition that alter the activation and/or activity of the bitter-sensing taste receptor cells and the PKD2L1- expressing taste receptor cells.

摘要翻译： 本发明是在味道领域中，涉及调节食欲或咸味食品中所需的咸味感觉味道的方法和组合物。 所述方法和组合物涉及改变苦味感受态受体细胞和表达PKD2L1的味觉受体细胞的活化和/或活性。 本发明还涉及含有改变苦味感受态细胞和表达PKD2L1的味觉受体细胞的活化和/或活性的试剂和组合物的食品和食品。

公开(公告)号：WO2014081980A3

公开(公告)日：2014-07-17

申请号：PCT/US2013071344

申请日：2013-11-21

申请人： UNIV COLUMBIA ,  BARASCH JONATHAN ,  QIU ANDONG

发明人： BARASCH JONATHAN ,  QIU ANDONG

IPC分类号： A61K38/00

CPC分类号： C07K14/47 ,  A61K38/00

摘要： In one aspect the present invention is directed to mutant NGAL proteins that have the ability to bind to siderophores, such as enterochelin, and to chelate and transport iron, and that are excreted in the urine. Such NGAL mutants, and complexes thereof with siderophores, can be used to clear excess iron from the body, for example in the treatment of iron overload. The NGAL mutants of the invention also have antibacterial activity and can be used in the treatment of bacterial infections, such as those of the urinary tract.

摘要翻译： 在一个方面，本发明涉及突变NGAL蛋白，其具有结合于铁载体如肠毒素并且螯合和运输铁并且在尿中排泄的能力。 这种NGAL突变体及其与铁载体的复合物可用于清除体内多余的铁，例如用于治疗铁超负荷。 本发明的NGAL突变体也具有抗菌活性，并可用于治疗细菌感染，例如泌尿道感染。