公开(公告)号：WO2016057702A3

公开(公告)日：2016-08-18

申请号：PCT/US2015054538

申请日：2015-10-07

Applicant: UNIV CORNELL

Inventor： LYDEN DAVID C ,  DA SILVA BRUNO COSTA

IPC: G01N33/68 ,  C12Q1/68

CPC classification number: G01N33/57438 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N2800/50

Abstract: The present invention is directed to a method for identifying an individual who is at risk for developing metastatic liver disease that involves measuring, in a sample isolated from the individual, exosomal levels of one or more markers of metastatic liver disease. Kits for carrying out this method are also disclosed. The present invention also relates to a method of preventing metastatic liver disease in an individual who are at risk for developing the disease that involves administering one or more inhibitors of liver premetastatic niche formation.

Abstract translation: 本发明涉及用于鉴定处于发生转移性肝病风险的个体的方法，其涉及在从个体分离的样品中测量转移性肝病的一种或多种标记物的外泌体水平。 还公开了执行这种方法的试剂盒。 本发明还涉及预防有发展疾病风险的个体的转移性肝脏疾病的方法，所述疾病涉及施用一种或多种肝前转氨酶生态位形成抑制剂。