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    SYSTEM AND METHODS FOR THREE-DIMENSIONAL PRINTING
    1.
    发明申请
    SYSTEM AND METHODS FOR THREE-DIMENSIONAL PRINTING 审中-公开
    用于三维打印的系统和方法

    公开(公告)号：WO2016040507A8

    公开(公告)日：2017-05-26

    申请号：PCT/US2015049224

    申请日：2015-09-09

    Applicant: UNIV CORNELL

    Inventor： GUIMBRETIERE FRANCOIS ,  IM SANGHA ,  BAUDISCH PATRICK ,  MÜLLER STAFANIE ,  GUREVICH SERAFIMA ,  PFISTERER LISA ,  TEIBRICH ALEXANDER

    IPC: G06F19/00

    CPC classification number: G05B19/4099 ,  G05B2219/49023

    Abstract: A fast and economical system and methods directed to low-fidelity fabrication of three-dimensional (3D) objects using 3D printing. The invention facilitates rapid prototyping by providing a wireframe structure in the form of the underlying design structure of a 3D model, which may be useful for a variety of reasons including to provide a prototype preview that may be used for design validation of a 3D model.

    Abstract translation: 一种快速和经济的系统和方法，针对使用3D打印低保真度制造三维（3D）物体。 本发明通过以3D模型的基础设计结构的形式提供线框结构来促进快速原型设计，这可以用于多种原因，包括提供可以用于3D模型的设计验证的原型预览。

    METHODS FOR PROGNOSING AND PREVENTING METASTATIC LIVER DISEASE
    2.
    发明申请
    METHODS FOR PROGNOSING AND PREVENTING METASTATIC LIVER DISEASE 审中-公开
    预防和预防转移性肝病的方法

    公开(公告)号：WO2016057702A3

    公开(公告)日：2016-08-18

    申请号：PCT/US2015054538

    申请日：2015-10-07

    Applicant: UNIV CORNELL

    Inventor： LYDEN DAVID C ,  DA SILVA BRUNO COSTA

    IPC: G01N33/68 ,  C12Q1/68

    CPC classification number: G01N33/57438 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N2800/50

    Abstract: The present invention is directed to a method for identifying an individual who is at risk for developing metastatic liver disease that involves measuring, in a sample isolated from the individual, exosomal levels of one or more markers of metastatic liver disease. Kits for carrying out this method are also disclosed. The present invention also relates to a method of preventing metastatic liver disease in an individual who are at risk for developing the disease that involves administering one or more inhibitors of liver premetastatic niche formation.

    Abstract translation: 本发明涉及用于鉴定处于发生转移性肝病风险的个体的方法，其涉及在从个体分离的样品中测量转移性肝病的一种或多种标记物的外泌体水平。 还公开了执行这种方法的试剂盒。 本发明还涉及预防有发展疾病风险的个体的转移性肝脏疾病的方法，所述疾病涉及施用一种或多种肝前转氨酶生态位形成抑制剂。

    DETECTION OF DNA METHYLATION USING COMBINED NUCLEASE LIGATION REACTIONS
    3.
    发明申请
    DETECTION OF DNA METHYLATION USING COMBINED NUCLEASE LIGATION REACTIONS 审中-公开
    联合核酸连接反应检测DNA甲基化

    公开(公告)号：WO2015153571A3

    公开(公告)日：2015-12-30

    申请号：PCT/US2015023535

    申请日：2015-03-31

    Applicant: UNIV CORNELL

    Inventor： BARANY FRANCIS

    IPC: C12Q1/68 ,  C40B20/00 ,  C40B30/04 ,  C40B40/06

    CPC classification number: C12Q1/683 ,  C12Q2521/331 ,  C12Q2525/301 ,  C12Q2561/109 ,  C12Q2533/107

    Abstract: The present invention is directed to methods for identifying the presence of one or more methylated or unmethylated target nucleotide sequences in a sample that involve coupled methylation sensitive restriction enzyme digestion-ligation and/or extension processes. In some embodiments, the ligation and primary extension products formed in the reaction processes of the present invention are subsequently amplified using a polymerase chain reaction. The ligation products or primary extension products are detected, and the presence of one or more methylated or unmethylated target nucleotide sequences in the sample is identified based on the detection.

    Abstract translation: 本发明涉及鉴定样品中一种或多种甲基化或非甲基化靶核苷酸序列的存在的方法，其涉及偶联的甲基化敏感性限制酶消化 - 连接和/或延伸过程。 在一些实施方案中，随后使用聚合酶链式反应扩增在本发明的反应过程中形成的连接和初级延伸产物。 检测连接产物或初级延伸产物，并基于检测鉴定样品中一种或多种甲基化或未甲基化的靶核苷酸序列的存在。

    DIVIDED PULSE LASERS
    4.
    发明申请
    DIVIDED PULSE LASERS 审中-公开
    分开的脉冲激光

    公开(公告)号：WO2015134123A3

    公开(公告)日：2015-12-30

    申请号：PCT/US2015012322

    申请日：2015-01-21

    Applicant: UNIV CORNELL

    Inventor： WISE FRANK W ,  LAMB ERIN STRANFORD ,  WRIGHT LOGAN G

    IPC: H01S3/08 ,  H01S3/11

    CPC classification number: H01S3/06712 ,  H01S3/06791 ,  H01S3/08 ,  H01S3/08054 ,  H01S3/081 ,  H01S3/0826 ,  H01S3/10046 ,  H01S3/1118 ,  H01S3/1618 ,  H01S3/2333 ,  H01S2301/085

    Abstract: Methods, systems, and devices are disclosed for divided-pulse lasers. In one aspect, a pulsed laser is provided to include a laser cavity including an optical amplifier and a plurality of optical dividing elements and configured to direct a laser pulse of linearly polarized light into the plurality of optical dividing elements to divide the light of the laser pulse into a sequence of divided pulses each having a pulse energy being a portion of the energy of the laser pulse before entry of the optical dividing elements, to subsequently direct the divided pulses into the optical amplifier to produce amplified divided pulses. The laser cavity is configured to direct the amplified divided pulses back into the plurality of optical dividing elements for a second time in an opposite direction to recombine the amplified divided pulses into a single laser pulse with greater pulse energy as an output pulse of the laser cavity.

    Abstract translation: 公开了用于分割脉冲激光器的方法，系统和装置。 一方面，提供脉冲激光器以包括激光腔，该激光腔包括光学放大器和多个光学分割元件，并且被配置为将线性偏振光的激光脉冲引导到多个光学分割元件中以将激光的光 脉冲成分割脉冲序列，每个分割脉冲具有作为激光脉冲能量的一部分的脉冲能量进入光学分割元件之前，随后将分割的脉冲引导到光放大器中以产生放大的分频脉冲。 激光腔被配置为将放大的分离脉冲反向回到多个光学分割元件中，以相反的方向第二次将放大的分割脉冲重新组合成具有较大脉冲能量的单个激光脉冲作为激光腔的输出脉冲 。

    YOKE-SHELL NANOPARTICLE, METHOD AND APPLICATIONS
    6.
    发明申请
    YOKE-SHELL NANOPARTICLE, METHOD AND APPLICATIONS 审中-公开
    YOKE-SHELL NANOPARTICLE，METHOD AND APPLICATIONS

    公开(公告)号：WO2015003184A3

    公开(公告)日：2015-04-09

    申请号：PCT/US2014045573

    申请日：2014-07-07

    Applicant: UNIV CORNELL

    Inventor： YU YINGCHAO ,  ZHOU WEIDONG ,  CHEN HAO ,  ABRUÑA HÉCTOR D

    IPC: H01M6/14

    CPC classification number: H01M4/366 ,  H01M4/0404 ,  H01M4/134 ,  H01M4/136 ,  H01M4/1395 ,  H01M4/1397 ,  H01M4/38 ,  H01M4/5815 ,  H01M4/602 ,  H01M10/052 ,  H01M10/0525 ,  Y02T10/7011

    Abstract: A nanoparticle and a method for fabricating the nanoparticle utilize a decomposable material yoke located within permeable organic polymer material shell and separated from the permeable organic polymer material shell by a void space. When the decomposable material yoke comprises a sulfur material and the permeable organic polymer material shell comprises a material permeable to both a sulfur material vapor and a lithium ion within a battery electrolyte the nanoparticle may be used within an electrode for a Li/S battery absent the negative effects of battery electrode materials expansion.

    Abstract translation: 纳米颗粒和制造纳米颗粒的方法利用位于可渗透有机聚合物材料壳内的可分解材料轭，并通过空隙空间与可渗透的有机聚合物材料壳分离。 当可分解材料轭包含硫材料并且可渗透有机聚合物材料壳包含在电池电解质内可渗透硫材料蒸汽和锂离子的材料时，纳米颗粒可用于Li / S电池的电极中，不存在 电池电极材料的负面影响扩大。

    FLOATING GATE BASED SENSOR APPARATUS AND APPLICATIONS
    8.
    发明申请
    FLOATING GATE BASED SENSOR APPARATUS AND APPLICATIONS 审中-公开
    基于闸门的传感器装置和应用

    公开(公告)号：WO2014197891A3

    公开(公告)日：2015-01-29

    申请号：PCT/US2014041507

    申请日：2014-06-09

    Applicant: UNIV CORNELL

    Inventor： JAYANT KRISHNA ,  KAN EDWIN C

    IPC: G01N27/06 ,  G01N27/22 ,  H01L29/788

    CPC classification number: G01N27/4145 ,  C12Q1/6869 ,  C12Q1/703 ,  C12Q2600/158 ,  G01N27/4146 ,  H01L29/42328 ,  H01L29/42364 ,  C12Q2527/119 ,  C12Q2565/607

    Abstract: A floating gate based sensor apparatus includes at least two separate electrical bias components with respect to a floating gate based sensor surface within the floating gate based sensor apparatus. By including the at least two electrical bias components, the floating gate based sensor apparatus provides enhanced capabilities for biomaterial and non-biomaterial detection and manipulation while using the floating gate based sensor apparatus.

    Abstract translation: 基于浮动栅极的传感器装置包括相对于基于浮动栅极的传感器装置内的基于浮动栅极的传感器表面的至少两个分离的电偏压分量。 通过包括至少两个电偏压部件，基于浮动栅的传感器装置在使用基于浮动栅的传感器装置的同时提供增强的生物材料和非生物材料检测和操作的能力。

    NASAL SPRAY DELIVERY GUIDE
    9.
    发明申请
    NASAL SPRAY DELIVERY GUIDE 审中-公开
    NASAL喷雾传送指南

    公开(公告)号：WO2014205093A2

    公开(公告)日：2014-12-24

    申请号：PCT/US2014042973

    申请日：2014-06-18

    Applicant: UNIV CORNELL ,  NASALIGN LLC

    Inventor： REISACHER WILLIAM ,  BERGLUND ERICK B ,  NELSON MICHAEL

    IPC: A61M11/02

    CPC classification number: A61M11/00 ,  A61M11/08 ,  A61M15/085 ,  A61M2209/088 ,  A61M2210/0618

    Abstract: A nasal spray delivery guide including a pair of guide elements spaced apart from one another and configured to be at least partially inserted into respective nostrils of a patient, and a flexible connector element attached to and extending between the guide elements. Each guide element includes an aperture extending therethrough from a base end to a tip end of the guide element. A method for delivering a nasal spray into a patient's nose includes the steps of providing the nasal spray delivery guide, inserting the guide elements at least partially into respective nostrils of the patient, inserting at least a portion of a nasal spray delivery device into one of the guide elements, and activating the nasal spray delivery device to deliver a nasal spray to a lateral wall of the respective nasal cavity.

    Abstract translation: 一种鼻喷雾输送引导件，其包括彼此间隔开并构造成至少部分地插入到患者的相应鼻孔中的一对引导元件，以及附接到引导元件之间并在引导元件之间延伸的柔性连接器元件。 每个引导元件包括从引导元件的基端延伸穿过其中的孔。 将鼻喷雾器递送到患者鼻部的方法包括以下步骤：提供鼻喷雾输送引导件，将引导元件至少部分地插入患者的相应鼻孔中，将至少一部分鼻喷雾输送装置插入到 引导元件，以及激活鼻喷雾递送装置以将鼻喷雾物递送到相应鼻腔的侧壁。

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