公开(公告)号：WO2007002120A3

公开(公告)日：2007-11-15

申请号：PCT/US2006024031

申请日：2006-06-22

Applicant: UNIV DUKE ,  KOJIMA KAIHEI ,  HEITMAN JOSEPH ,  BAHN YO-SUN

Inventor： KOJIMA KAIHEI ,  HEITMAN JOSEPH ,  BAHN YO-SUN

IPC: A01N47/00

CPC classification number: A61K31/4025 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention concerns methods of treating fungal infections and methods of screening compounds for activity in treating fungal infections. Methods of the invention include using an active compound such as fludioxonil to treat a Cryptococcus neoformans infection. Also included are methods and pharmaceutical compositions useful for treating fungal infections using a Hog1 activator such as fludioxonil and a calcineurin inhibitor in combination.

Abstract translation: 本发明涉及治疗真菌感染的方法和筛选化合物治疗真菌感染活性的方法。 本发明的方法包括使用活性化合物如氟虫腈来治疗新型隐球菌感染。 还包括可用于使用Hog1激活剂如氟二氧化物和钙调神经磷酸酶抑制剂组合治疗真菌感染的方法和药物组合物。