公开(公告)号：WO0064911A9

公开(公告)日：2002-07-11

申请号：PCT/US0011262

申请日：2000-04-27

Applicant: UNIV GEORGETOWN

Inventor： KOZIKOWSKI ALAN P ,  WROBLEWSKI JARDA T ,  NAN FAJUN

IPC: A61K31/662 ,  A61K31/194 ,  A61K31/197 ,  A61K31/198 ,  A61K31/22 ,  A61K31/225 ,  A61P3/00 ,  A61P9/00 ,  A61P9/10 ,  A61P25/00 ,  A61P25/02 ,  A61P25/08 ,  A61P25/16 ,  A61P25/28 ,  A61P31/04 ,  A61P39/00 ,  A61P41/00 ,  A61P43/00 ,  C07C59/347 ,  C07C69/716 ,  C07C275/16 ,  C07C335/08 ,  C07F9/30 ,  C07F9/32 ,  C07C273/16

CPC classification number: C07C335/08 ,  C07C59/347 ,  C07C69/716 ,  C07F9/301

Abstract: The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or both. The present invention also relates to methods of modulating the activity of a metabotropic glutamate receptor or a NAALADase enzyme or both, e.g., in a subject in need thereof, using a compound or formulation of the present invention. The present invention also relates to methods of treating a subject suffering from a chronic or acute disease, malady or condition due at least in part to an abnormality in the activity of an endogenous metabotropic glutamate receptor or a NAALADase enzyme or both, using a compound or formulation of the present invention.

Abstract translation: 本发明涉及其化合物是代谢型谷氨酸受体或NAALADase酶或两者的配体，例如激动剂或拮抗剂的新化合物及其制剂。 本发明还涉及使用本发明的化合物或制剂调节代谢型谷氨酸受体或NAALADase酶或两者的活性的方法，例如在有需要的受试者中。 本发明还涉及使用化合物或至少部分由内源性代谢型谷氨酸受体或NAALADase酶或两者的活性异常而治疗患有慢性或急性疾病，疾病或病症的受试者的方法， 本发明的制剂。