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1.发明申请ENZYMATIC PRODUCTION OR CHEMICAL SYNTHESIS AND USES FOR 5,7-DIENES AND UVB CONVERSION PRODUCTS THEREOF 审中-公开合成生产或化学合成及其用于5,7-二烯和UVB转化产物的用途
公开(公告)号：WO2009108388A8
公开(公告)日：2010-07-01
申请号：PCT/US2009001324
申请日：2009-03-02
Applicant: UNIV TENNESSEE RES FOUNDATION
Inventor： SLOMINSKI ANDRZEJ , LI WEI , ZBYTEK BLAZEJ , TUCKEY ROBERT C , ZJAWIONY JORDAN K , NGUYEN MINH NGOC , ZMIJEWSKL MICHAL A , JANJETOVIC ZORICA , SWEATMAN TREVOR W , MILLER DUANE D , CHEN JIANJUN
CPC classification number: C07C401/00 , A61K8/63 , A61K2800/81 , A61K2800/94 , A61Q19/00 , C07J3/00 , C07J11/00 , C12P7/02
Abstract: Provided herein are steroidal compounds that are androsta-5,7-dienes or a pregna-5,7-dienes and ultraviolet B (UVB) conversion products thereof which includes pharmaceutical compositions of the steroidal compounds. Also provided is a method for producing hydroxylated metabolites of cholecalciferol via the P450scc (CYPl IA 1) or CYP27B 1 enzyme systems and the hydroxylated metabolites so produced. In addition, a method for inhibiting proliferation of either a normally or abnormally proliferating cell by contacting the cell with any of the compounds described herein. A related method is provided of treating a condition associated with the proliferating cell such as a cancer, a skin disorder, a defect in cell differentiation, cosmetic, prophylaxsis, or healthy cell maintenance.
Abstract translation: 本文提供的甾族化合物是雄激素-5,7-二烯或其前体-5,7-二烯和紫外线B（UVB）转化产物，其包括甾体化合物的药物组合物。 还提供了通过P450scc（CYP119A）或CYP27B1酶系统和如此制备的羟基化代谢产物来产生胆钙化甾醇的羟基化代谢物的方法。 此外，通过使细胞与本文所述的任何化合物接触来抑制正常或异常增殖细胞增殖的方法。 提供了一种相关方法来治疗与增殖细胞相关的病症，例如癌症，皮肤病症，细胞分化缺陷，化妆品，预防或健康细胞维持。
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2.发明申请HYDROXYLATED FORMS OF ERGOSTEROLS AND ERGOCALCIFEROLS, DERIVATIVES THEREOF, METHODS OF PRODUCTION AND USES THEREOF 审中-公开ERGOSTEROLS和ERGOCALCIFEROL的羟基化形式，其衍生物，其制备方法和用途
公开(公告)号：WO2007006036A3
公开(公告)日：2007-08-09
申请号：PCT/US2006026476
申请日：2006-07-05
Applicant: UNIV TENNESSEE RES FOUNDATION
Inventor： SLOMINSKI ANDRZEJ , TUCKEY ROBERT , LI WEI , ZBYTEK BLAZEJ , ZJAWIONY JORDAN , WORTSMAN JACOBO
IPC: A61K31/54 , C07C401/00
CPC classification number: C07J9/00
Abstract: Provided herein is an enzymatic method of producing hydroxylated ergosterols and hydroxylated ergocalciferols using the cytochrome P450scc enzyme and/or the CYP27B1 enzyme and the hydroxylated compounds so produced. Also provided are methods of using the hydroxylated ergosterols and hydroxylated ergocalciferols to treat a tumor or other pathophysiologic condition.
Abstract translation: 本文提供了使用细胞色素P450scc酶和/或CYP27B1酶和如此产生的羟基化化合物生产羟基化麦角甾醇和羟基化麦角骨化醇的酶促方法。 还提供了使用羟基化麦角甾醇和羟基化麦角骨化醇治疗肿瘤或其他病理生理状况的方法。
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3.发明申请ENZYMATIC METHOD TO PRODUCE 7-DEHYDROPREGNENOLONE, VITAMIN D3-LIKE COMPOUNDS AND DERIVATIVES THEREOF 审中-公开生产7-脱氢萘酚，维生素D 3 - 类化合物及其衍生物的酶法
公开(公告)号：WO2005067673A2
公开(公告)日：2005-07-28
申请号：PCT/US2005000676
申请日：2005-01-06
Applicant: UNIV TENNESSEE RES FOUNDATION
Inventor： SLOMINSKI ANDRZEJ , TUCKEY ROBERT , ZJAWIONY JORDAN , STEWART D JEREMY , WORTSMAN JACOBO
IPC: A61K31/59 , C07C401/00 , C12P7/02 , C12P33/00
CPC classification number: C12P33/005 , C12P7/02 , C12P33/00
Abstract: Provided herein are enzymatic methods of producing steroid compounds S such as 7-dehydropregnenolone, hydroxy derivatives thereof and vitamin D2- and D3- like compounds and derivatives thereof. Also provided are the derivatives of the vitamin D3-like compounds so generated via the action of cytochrome P450scc enzyme on substrates 7-dehydrocholesterol, vitamin D2 or vitamin D3.
Abstract translation: 本文提供了产生类固醇化合物S如7-脱水孕烯醇酮，其羟基衍生物和维生素D2-和D3-样化合物及其衍生物的酶学方法。 还提供了通过细胞色素P450scc酶对底物7-脱氢胆固醇，维生素D2或维生素D3的作用产生的维生素D3样化合物的衍生物。
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