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    TERNARY METAL HALIDE SCINTILLATOR
    1.
    发明申请
    TERNARY METAL HALIDE SCINTILLATOR 审中-公开
    三元金属卤化物闪烁体

    公开(公告)号：WO2015010055A4

    公开(公告)日：2015-03-19

    申请号：PCT/US2014047248

    申请日：2014-07-18

    Applicant: UNIV TENNESSEE RES FOUNDATION

    Inventor： STAND LUIS ,  ZHURAVLEVA MARIYA ,  MELCHER CHARLES L

    IPC: C09K11/85 ,  C09K11/08

    CPC classification number: C09K11/7733 ,  G01T1/2006 ,  G01T1/2018 ,  G01T1/2023 ,  G21K4/00 ,  G21K2004/10

    Abstract: Metal halide scintillators are described. More particularly, the scintillators include doped (e.g., europium-doped) ternary metal halides, such as those of the formulas A2BX4 and AB2X5, wherein A is an alkali metal, such as Li, Na, K, Rb, Cs or any combination thereof; B is an alkali earth metal, such as Be, Mg, Ca, Sr, Ba or any combination thereof; and X is a halide, such as CI, Br, I, F or any combination thereof. Radiation detectors comprising the novel metal halide scintillators and other ternary metal halides, such as those of the formulas A2EuX4 and AEu2X5, wherein A is an alkali metal and X is a halide, are also described.

    Abstract translation: 描述金属卤化物闪烁体。 更特别地，闪烁器包括掺杂的（例如铕掺杂的）三元金属卤化物，例如式A2BX4和AB2X5的那些，其中A是碱金属，例如Li，Na，K，Rb，Cs或其任何组合 ; B是碱土金属，如Be，Mg，Ca，Sr，Ba或其任何组合; X是卤化物，如Cl，Br，I，F或其任何组合。 还描述了包含新型金属卤化物闪烁体和其他三元金属卤化物（例如式A2EuX4和AEu2X5的那些）的辐射探测器，其中A是碱金属并且X是卤化物。

    CODOPING METHOD FOR MODIFYING THE SCINTILLATION AND OPTICAL PROPERTIES OF GARNET-TYPE SCINTILLATORS
    2.
    发明申请
    CODOPING METHOD FOR MODIFYING THE SCINTILLATION AND OPTICAL PROPERTIES OF GARNET-TYPE SCINTILLATORS 审中-公开
    修改GARNET型扫描仪的扫描和光学性质的方法

    公开(公告)号：WO2014171985A3

    公开(公告)日：2014-12-31

    申请号：PCT/US2014012799

    申请日：2014-01-23

    Applicant: UNIV TENNESSEE RES FOUNDATION

    Inventor： TYAGI MOHIT ,  KOSCHAN MERRY A ,  MELCHER CHARLES L ,  DONNALD SAMUEL BRADLEY

    IPC: C09K11/78 ,  C09K11/08 ,  C09K11/80

    CPC classification number: C09K11/7706 ,  C09K11/7774 ,  C30B15/04 ,  C30B29/28 ,  G01T1/2023 ,  G21K2004/06

    Abstract: A method of tailoring the properties of garnet-type scintillators to meet the particular needs of different applications is described. More particularly, codoping scintillators, such as Gd3Ga3AI2012, Gd3Ga2AI3012, or other rare earth gallium aluminum garnets, with different ions can modify the scintillation light yield, decay time, rise time, energy resolution, proportionality, and/or sensitivity to light exposure. Also provided are the codoped garnet-type scintillators themselves, radiation detectors and related devices comprising the codoped garnet-type scintillators, and methods of using the radiation detectors to detect gamma rays, X-rays, cosmic rays, and particles having an energy of 1 keV or greater.

    Abstract translation: 描述了一种调整石榴石型闪烁体的性能以满足不同应用的特殊需求的方法。 更具体地，具有不同离子的共掺杂闪烁体，例如Gd 3 Ga 3 Al 1/2 O 2，Gd 3 Ga 2 Al 3 O 12，或其它稀土镓铝石榴石，可以改变闪光的产量，衰变时间，上升时间，能量分辨率，比例和/或对曝光的敏感性。 还提供了共同掺杂的石榴石型闪烁体本身，辐射检测器和包括共掺杂石榴石型闪烁体的相关装置，以及使用辐射检测器来检测伽马射线，X射线，宇宙射线和能量为1的颗粒的方法 keV或更大。

    GLYPHOSATE-INDUCIBLE PROMOTER ITS USE
    4.
    发明申请
    GLYPHOSATE-INDUCIBLE PROMOTER ITS USE 审中-公开
    甘草酸诱导促进剂的用途

    公开(公告)号：WO2012012412A2

    公开(公告)日：2012-01-26

    申请号：PCT/US2011044516

    申请日：2011-07-19

    Applicant: UNIV TENNESSEE RES FOUNDATION ,  STEWART C NEAL ,  PENG YANHUI

    Inventor： STEWART C NEAL ,  PENG YANHUI

    IPC: A01H5/00 ,  C12N15/11 ,  C12N15/63 ,  C12N15/82

    CPC classification number: C12N15/8238 ,  C07K14/415

    Abstract: The subject application provides polynucleotides, compositions thereof and methods for regulating gene expression in a plant using a promoter that initiates transcription in an inducible manner. In a further aspect of the invention, methods for modulating expression of a gene product in a stably transformed plant comprising the steps of (a) transforming a plant cell with a DNA construct comprising the disclosed promoter or fragments thereof that are capable of driving the expression of an operably linked nucleic acid sequence operably linked to at least one nucleotide sequence; (b) growing the plant cell under plant growing conditions and (c) regenerating a stably transformed plant from the plant cell wherein the induced expression of the operably linked nucleotide sequence alters the phenotype of the plant.

    Abstract translation: 本申请提供了多核苷酸，其组合物和使用以诱导型方式启动转录的启动子在植物中调节基因表达的方法。 在本发明的另一方面，用于调节稳定转化植物中基因产物表达的方法包括以下步骤：（a）用DNA构建体转化植物细胞，所述DNA构建体包含能够驱动表达的公开的启动子或其片段 与至少一个核苷酸序列可操作连接的有效连接的核酸序列; （b）在植物生长条件下培养植物细胞，和（c）从植物细胞再生稳定转化的植物，其中可操作地连接的核苷酸序列的诱导表达改变植物的表型。

    GLYCAN-BINDING PROTEINS AS THERAPEUTIC TARGETS FOR RETINAL DISORDERS AND TREATMENT METHODS BASED THEREON
    5.
    发明申请
    GLYCAN-BINDING PROTEINS AS THERAPEUTIC TARGETS FOR RETINAL DISORDERS AND TREATMENT METHODS BASED THEREON 审中-公开
    作为治疗性疾病治疗目标的GLYCAN结合蛋白及其治疗方法

    公开(公告)号：WO2008121768A3

    公开(公告)日：2009-12-30

    申请号：PCT/US2008058576

    申请日：2008-03-28

    Applicant: UNIV TENNESSEE RES FOUNDATION ,  JABLONSKI MONICA M

    Inventor： JABLONSKI MONICA M

    IPC: A61K31/715

    CPC classification number: A61K31/726

    Abstract: Disclosed are novel methods of treatment for retinal diseases and conditions including age- related macular degeneration, genetic-based retinal degenerations and retinal detachment. A novel glycan binding protein thought to be a cell surface receptor has been discovered in the retina. The retinal glycan binding receptor is shown to play an important role in promoting assembly of outer segment (OS) membranes by the photoreceptor cells of the eye, a process that is essential for vision. Based on the finding that certain sugars can bind with very high affinity to the retinal glycan receptor and stimulate its function, the invention provides novel therapeutic agents for treatment of retinal diseases that are multivalent N-linked glycans. Preferred pharmaceutical compositions in accordance with the present invention comprise active agents having the general formula: (Gal-GlcNAc)n-Man3-GlcN Ac2, where n is 1-4. Particularly preferred multivalent glycans are galactosylated, biantennary (NA2), and asialo, galactosylated, triantennary (NA3) oligosaccharides.

    Abstract translation: 公开了用于视网膜疾病和病症的新型治疗方法，包括年龄相关性黄斑变性，遗传性视网膜变性和视网膜脱离。 在视网膜中已经发现被认为是细胞表面受体的新型聚糖结合蛋白。 显示视网膜聚糖结合受体在促进眼睛光感受器细胞外壳（OS）膜的组装中发挥重要作用，这是对视力至关重要的过程。 基于某些糖可以以非常高的亲和力结合到视网膜聚糖受体并刺激其功能的发现，本发明提供用于治疗作为多价N-连接聚糖的视网膜疾病的新型治疗剂。 根据本发明的优选药物组合物包含具有以下通式的活性剂：（Gal-GlcNAc）n-Man3-GlcN Ac2，其中n为1-4。 特别优选的多价聚糖是半乳糖基化的，双向的（NA2）和脱唾液酸，半乳糖基化的三硝基（NA3）寡糖。

    ENZYMATIC PRODUCTION OR CHEMICAL SYNTHESIS AND USES FOR 5,7-DIENES AND UVB CONVERSION PRODUCTS THEREOF
    6.
    发明申请
    ENZYMATIC PRODUCTION OR CHEMICAL SYNTHESIS AND USES FOR 5,7-DIENES AND UVB CONVERSION PRODUCTS THEREOF 审中-公开
    合成生产或化学合成及其用于5,7-二烯和UVB转化产物的用途

    公开(公告)号：WO2009108388A3

    公开(公告)日：2009-12-03

    申请号：PCT/US2009001324

    申请日：2009-03-02

    Applicant: UNIV TENNESSEE RES FOUNDATION

    Inventor： ZJAWIONY JORDAN K ,  LI WEI ,  ZBYTEK BLAZEJ ,  TUCKEY ROBERT C ,  NGUYEN MINH NGOC ,  ZMIJEWSKL MICHAL A ,  JANJETOVIC ZORICA ,  SWEATMAN TREVOR W ,  MILLER DUANE D ,  CHEN JIANJUN

    IPC: A61K8/63 ,  A61P35/00 ,  C07J3/00 ,  C07J11/00

    CPC classification number: C07C401/00 ,  A61K8/63 ,  A61K2800/81 ,  A61K2800/94 ,  A61Q19/00 ,  C07J3/00 ,  C07J11/00 ,  C12P7/02

    Abstract: Provided herein are steroidal compounds that are androsta-5,7-dienes or a pregna-5,7-dienes and ultraviolet B (UVB) conversion products thereof which includes pharmaceutical compositions of the steroidal compounds. Also provided is a method for producing hydroxylated metabolites of cholecalciferol via the P450scc (CYPl IA 1) or CYP27B 1 enzyme systems and the hydroxylated metabolites so produced. In addition, a method for inhibiting proliferation of either a normally or abnormally proliferating cell by contacting the cell with any of the compounds described herein. A related method is provided of treating a condition associated with the proliferating cell such as a cancer, a skin disorder, a defect in cell differentiation, cosmetic, prophylaxsis, or healthy cell maintenance.

    Abstract translation: 本文提供的甾族化合物是雄激素-5,7-二烯或其前体-5,7-二烯和紫外线B（UVB）转化产物，其包括甾体化合物的药物组合物。 还提供了通过P450scc（CYP119A）或CYP27B1酶系统和如此制备的羟基化代谢产物来产生胆钙化甾醇的羟基化代谢物的方法。 此外，通过使细胞与本文所述的任何化合物接触来抑制正常或异常增殖细胞增殖的方法。 提供了一种相关方法来治疗与增殖细胞相关的病症，例如癌症，皮肤病症，细胞分化缺陷，化妆品，预防或健康细胞维持。

    METHODS AND COMPOSITIONS FOR MODULATING BK CHANNEL ACTIVITY AND VASODILATION
    9.
    发明申请
    METHODS AND COMPOSITIONS FOR MODULATING BK CHANNEL ACTIVITY AND VASODILATION 审中-公开
    调节BK通道活性和血管舒缩的方法和组合物

    公开(公告)号：WO2008085492A3

    公开(公告)日：2008-09-12

    申请号：PCT/US2007026364

    申请日：2007-12-27

    Applicant: UNIV TENNESSEE RES FOUNDATION ,  DOPICO ALEJANDRO M ,  BUKIYA ANNA NODAROVNA ,  LIU JIANXI

    Inventor： DOPICO ALEJANDRO M ,  BUKIYA ANNA NODAROVNA ,  LIU JIANXI

    IPC: A61K31/56

    CPC classification number: A61K31/575

    Abstract: Methods and compositions are provided for modulating myocyte BK channel activity and for screening for modulators of BK channel activity. The methods and compositions are useful in the treatment of disorders where increasing myocyte BK channel activity can attenuate, revert or prevent the disorder. For example, the methods and compositions are useful for treating disorders ameliorated by increasing vasodilation and blood flow in a subject, in particular, increasing cerebral blood flow.

    Abstract translation: 提供了调节肌细胞BK通道活性和筛选BK通道活性调节剂的方法和组合物。 该方法和组合物可用于治疗增加肌细胞BK通道活性可减弱，恢复或预防疾病的病症。 例如，所述方法和组合物可用于治疗通过增加受试者的血管舒张和血流而改善的病症，特别是增加脑血流量。

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