公开(公告)号：WO2018104528A1

公开(公告)日：2018-06-14

申请号：PCT/EP2017/082074

申请日：2017-12-08

Applicant: UNIVERSITÄTSKLINIKUM HAMBURG-EPPENDORF

Inventor： NOLTE, Friedrich ,  EDEN, Thomas ,  WESOLOWSKI, Janusz ,  MENZEL, Stephan

IPC: A01K67/027 ,  C07K16/00

Abstract: The present invention contemplates isolated polynucleotide for the production of a VHH-containing heavy chain antibody in a mammal and vectors comprising said isolated polynucleotide. Moreover, the invention relates to a transgenic mammal comprising the vector for the production of a VHH-containing heavy chain antibody. Further, the invention relates to VHH-containing heavy chain antibodies as well as methods for the production and cloning of VHH-containing heavy chain antibodies.