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公开(公告)号：WO2023021186A1
公开(公告)日：2023-02-23
申请号：PCT/EP2022/073194
申请日：2022-08-19
发明人： NOLTE, Friedrich , MENZEL, Stephan , MAGNUS, Tim , HAAG, Friedrich , DUAN, Yinghui , RISSIEK, Björn
摘要： The invention relates to antigen-binding polypeptides comprising the CDR1, CDR2 and CDR3 region of a VHH domain of a camelid heavy chain antibody. The polypeptides bind specifically to CD73 and are therefore suitable for the diagnosis as well as for the therapeutic and prophylactic treatment of diseases characterised by increased CD73 expression. Conjugates and pharmaceutical compositions comprising the antigen-binding polypeptides are also disclosed. In addition, the invention relates to the use of such antigen-binding polypeptides in methods for detecting CD73 or CD73-expressing cells in a biological sample. Methods for purifying and concentrating CD73 or CD73-expressing cells using the antigen-binding poly- peptides are also described.
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公开(公告)号：WO2013087857A2
公开(公告)日：2013-06-20
申请号：PCT/EP2012/075584
申请日：2012-12-14
发明人： NOLTE, Friedrich , UNGER, Mandy
CPC分类号： C07K16/1282 , A61K2039/505 , C07K16/40 , C07K2317/22 , C07K2317/569 , C07K2317/76
摘要： Die Erfindung betrifft Antigen-bindende Polypeptide, die die CDR1-, CDR2-, und CDR3-Region einer VHH-Domäne eines Kamelid-Schwereketten-Antikörpers umfassen. Die Polypeptide binden spezifisch im Bereich der Aminosäuren 1-800 eines Glykosyltransferase-Aktivität aufweisenden Toxins von Clostridium difficile. Die Antigen-bindenden Polypeptide eignen sich ins- besondere für die therapeutische Behandlung einer Erkrankung, die durch ein Glykosyltransferase-Aktivität aufweisendes Toxin von Clostridium difficileverursacht wird, sowie für die Diagnose einer solchen Erkrankung. Darüber hinaus betrifft die Erfindung die Verwendung solcher Antigen-bindenden Polypeptide in Verfahren zum Nachweis eines Glykosyltransferase-Aktivität aufweisenden Toxins von Clostridium difficilein einer biologischen Probe. Verfahren zur Aufreinigung und/oder Aufkonzentrierung eines Glykosyltransferase-Aktivität aufweisenden Toxins von Clostridium difficile, bei denen die Antigenbindenden Polypeptide zur Anwendung kommen, werden ebenfalls bereitgestellt.
摘要翻译： 本发明涉及包含骆驼重链抗体的VHH结构域的CDR1，CDR2和CDR3区域的抗原结合多肽。 多肽在艰难梭菌的糖基转移酶活化毒素的氨基酸1-800区域特异性结合。 抗原结合多肽对由艰难梭状芽孢杆菌的糖基转移酶活化毒素引起的疾病的治疗性处理以及诊断这种疾病特别有用。 DAR OVER此外，本发明涉及在用于检测糖基转移酶活＆AUML的方法中的用途，例如抗原结合多肽的;吨来自Clostridium毒素具有一个difficilein生物样品。 一种用于糖基转移酶活＆AUML的纯化和/或浓缩过程;还提供了包含吨艰难梭菌的毒素，其中所述抗原结合多肽用于。
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公开(公告)号：WO2019211401A1
公开(公告)日：2019-11-07
申请号：PCT/EP2019/061295
申请日：2019-05-02
摘要： The present invention relates to fusion proteins comprising a cell surface marker specific VHH. In particular, the invention relates to bispecific VHH adaptor proteins, i.e. fusion proteins comprising an adeno-associated virus (AAV) specific VHH linked to a cell surface marker specific VHH. Moreover, the invention relates to a recombinant AAV which comprises a fusion protein in which a cell surface marker specific VHH is integrated into a capsid protein of the AAV. Also nucleotide sequences encoding such fusion proteins, vectors are contemplated. The invention moreover refers to uses of the fusion proteins and nucleic sequences for gene therapy.
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公开(公告)号：WO2018104528A1
公开(公告)日：2018-06-14
申请号：PCT/EP2017/082074
申请日：2017-12-08
IPC分类号： A01K67/027 , C07K16/00
摘要： The present invention contemplates isolated polynucleotide for the production of a VHH-containing heavy chain antibody in a mammal and vectors comprising said isolated polynucleotide. Moreover, the invention relates to a transgenic mammal comprising the vector for the production of a VHH-containing heavy chain antibody. Further, the invention relates to VHH-containing heavy chain antibodies as well as methods for the production and cloning of VHH-containing heavy chain antibodies.
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公开(公告)号：WO2023021185A1
公开(公告)日：2023-02-23
申请号：PCT/EP2022/073192
申请日：2022-08-19
发明人： NOLTE, Friedrich , MENZEL, Stephan , MAGNUS, Tim , HAAG, Friedrich , DUAN, Yinghui , RISSIEK, Björn
IPC分类号： C07K16/28 , A61P35/00 , G01N33/574
摘要： The invention relates to antigen-binding polypeptides comprising the CDR1, CDR2 and CDR3 region of a VHH domain of a camelid heavy chain antibody. The polypeptides bind specifically to CD39 and are therefore suitable for the diagnosis as well as for the therapeutic and prophylactic treatment of diseases characterised by increased CD39 expression. Conjugates and pharmaceutical compositions comprising the antigen-binding polypeptides are also disclosed. In addition, the invention relates to the use of such antigen-binding polypeptides in methods for detecting CD39 or CD39-expressing cells in a biological sample. Methods for purifying and concentrating CD39 or CD39-expressing cells using the antigen-binding poly- peptides are also described.
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公开(公告)号：WO2021204781A1
公开(公告)日：2021-10-14
申请号：PCT/EP2021/058907
申请日：2021-04-06
发明人： NOLTE, Friedrich , MENZEL, Stephan , SUTER, Tobias , HOTTIGER, Michael , DORVIGNIT-PEDROSO, Denise , GLAUS-GARZON, Jesus , NOWAK, Kathrin , AIMI, Fabio
IPC分类号： A61K39/395 , A61P35/00 , C07K16/28 , C12N15/113 , G01N33/574 , A61K39/00
摘要： The present invention relates to a non-agonist ligand of ARTC1, which inhibits the ADP-ribosyltransferase activity of ARTC1, or an inhibitor nucleic acid sequence capable of downregulating or inhibiting expression of a target nucleic acid sequence encoding ARTC1, for use in prevention or treatment of cancer. The invention also relates to a method for diagnosis of cancer.
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公开(公告)号：WO2013087874A1
公开(公告)日：2013-06-20
申请号：PCT/EP2012/075617
申请日：2012-12-14
发明人： NOLTE, Friedrich , UNGER, Mandy
CPC分类号： C07K14/33 , C07K16/1282 , C07K2317/22 , C07K2317/569 , C07K2317/76 , C07K2317/92
摘要： Die Erfindung betrifft Antigen-bindende Polypeptide, die die CDR1-, CDR2-, und CDR3-Region einer VHH-Domäne eines Kamelid- Schwereketten-Antikörpers umfassen. Die Polypeptide binden spezifisch die CDTa-Untereinheit des CDT-Toxins von Clostridium difficile und eignen sich daher insbesondere für die therapeutische und prophylaktische Behandlung einer durch das CDT- Toxin verursachten Erkrankung sowie auch für die Diagnose einer solchen Erkrankung. Darüber hinaus betrifft die Erfindung die Verwendung solcher Antigen-bindenden Polypeptide in Verfahren zum Nachweis der CDTa-Untereinheit des CDT-Toxins von Clostridium difficile in einer biologischen Probe. Verfahren zur Aufreinigung und/oder Aufkonzentrierung der CDTa-Untereinheit des CDT-Toxins von Clostridium difficile , bei denen die Antigen-bindenden Polypeptide zur Anwendung kommen, werden ebenfalls bereitgestellt.
摘要翻译： 本发明涉及包含重链抗体Kamelid-的VHH结构域的CDR1，CDR2和CDR3区的抗原结合多肽。 多肽特异性结合艰难梭菌的毒素CDT的CDTA亚基，因此特别适合于引起CDT毒素，以及用于这样的疾病的诊断的疾病的治疗性和预防性治疗。 此外，本发明涉及在用于检测生物样品中的艰难梭菌的毒素CDT的CDTA亚基方法中的用途，例如抗原结合多肽的。 提供了一种用于艰难梭菌的毒素CDT的CDTA亚基的纯化和/或浓度，其中所述抗原结合多肽也可用于处理。
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