公开(公告)号：WO2017081211A2

公开(公告)日：2017-05-18

申请号：PCT/EP2016/077361

申请日：2016-11-10

Applicant: UNIVERSITY MEDICAL CENTER HAMBURG - EPPENDORF

Inventor： NOLTE, Friedrich ,  BANNAS, Peter ,  SCHÜTZE, Kerstin ,  FUMEY, William ,  SCHRIEWER, Levin ,  MENZEL, Stephan ,  STORTELERS, Catelijne

IPC: C07K16/28 ,  A61K39/395 ,  G01N33/53

CPC classification number: C07K16/2896 ,  A61K2039/505 ,  C07K2317/22 ,  C07K2317/31 ,  C07K2317/64 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  C12Q1/25 ,  G01N33/53

Abstract: The invention relates to polypeptides specifically binding to CD38 and are therefore suitable for the diagnosis and for the therapeutic and prophylactic treatment of diseases which are characterized by increased CD38 expression. Conjugates and pharmaceutical compositions comprising the polypeptides are disclosed as well. In addition, the invention relates to the use of such polypeptides in methods for the detection of CD38 and / or CD38-expressing cells in a biological sample. A process for the purification and concentration of CD38 and / or CD38-expressing cells in which the antigen-binding polypeptides are used are also described.

Abstract translation: 本发明涉及特异性结合CD38的多肽，因此适用于诊断和治疗和预防性治疗以CD38表达增加为特征的疾病。 还公开了包含该多肽的缀合物和药物组合物。 另外，本发明涉及这种多肽在检测生物样品中表达CD38和/或CD38的细胞的方法中的用途。 还描述了使用抗原结合多肽的CD38和/或CD38表达细胞的纯化和浓缩方法。