公开(公告)号：WO2023076988A1

公开(公告)日：2023-05-04

申请号：PCT/US2022/078765

申请日：2022-10-27

Applicant: UNIVERSITY OF CINCINNATI

Inventor： KOTAGIRI, Nalinikanth ,  THOMAS, Shindu C.

IPC: A61K35/74 ,  A61K9/50 ,  C12N1/20 ,  C12N9/24 ,  C12N15/62

Abstract: Provided herein is a hypervesiculating Escherichia coli Nissle (ΔECHy) bacterium engineered to produce outer membrane vesicles (OMVs), said OMVs packaging a fusion peptide including cytolysin A (ClyA) and hyaluronidase (Hy). Also provided are methods of remodeling a tumor, methods of treating cancer, and pharmaceutical compositions including the engineered ΔECHy bacterium.

公开(公告)号：WO2021212122A2

公开(公告)日：2021-10-21

申请号：PCT/US2021/028027

申请日：2021-04-19

Applicant: UNIVERSITY OF CINCINNATI

Inventor： KOTAGIRI, Nalinikanth ,  KAMBLE, Nitin S.

IPC: A61K35/74 ,  C12N15/62 ,  C12N15/74

Abstract: The present invention involves an engineered probiotic bacterium comprising a heterologous nucleic acid, where the heterologous nucleic acid comprises a nucleic acid sequence encoding an anti-spike glycoprotein nanobody of a coronavirus. In one embodiment, the bacterium is Escherichia coli Nissle 1917. In another embodiment, the anti-spike glycoprotein nanobody appears on the surface of the probiotic bacteria.

公开(公告)号：WO2020264307A1

公开(公告)日：2020-12-30

申请号：PCT/US2020/039839

申请日：2020-06-26

Applicant: UNIVERSITY OF CINCINNATI

Inventor： KOTAGIRI, Nalinikanth ,  SIDDIQUI, Nabil

IPC: A61K51/025 ,  A61K51/02 ,  A61K51/00 ,  C12Q1/16 ,  G01N33/60

Abstract: A probe for positron emission tomography (PET) is disclosed. The probe is selected from the group consisting of yersiniabactin (Ybt) labeled with Copper-64; staphylopine (StP) labeled with Copper-64; yersiniabactin (Ybt) labeled with Zirconium-89; and staphylopine (StP) labeled with Zirconium-89.