公开(公告)号：WO2022040790A1

公开(公告)日：2022-03-03

申请号：PCT/CA2021/051171

申请日：2021-08-24

Applicant: UNIVERSITY OF MANITOBA

Inventor： XING, Malcolm ,  LIU, Yuqing ,  CHEN, Shiyi

IPC: B01D67/00 ,  C02F1/40 ,  C02F1/58 ,  C08J3/24 ,  C08J5/18 ,  C08J7/04 ,  C08L29/04

Abstract: Herein, we demonstrate a hierarchical nano-structured water purification membrane fabricated with polyvinyl alcohol (PVA) nanofibers and polypyrrole (PPy) nanoparticles to achieve efficient emulsion separation with low oil-adhesion property as well as high-rate seawater desalination. The membrane exhibits the integrated properties of mechanical robustness, superhydrophilic/underwater superoleophobic wettability and broadband solar absorption.

公开(公告)号：WO2023070208A1

公开(公告)日：2023-05-04

申请号：PCT/CA2022/051582

申请日：2022-10-26

Applicant: UNIVERSITY OF MANITOBA

Inventor： XING, Malcolm

IPC: A61L24/04

Abstract: Building strong underwater bioadhesion is important for several applications but proved to be an extremely challenging task. In a wet/underwater environment, the water boundary layer hinders interfacial adhesion, which is further undermined by water-induced swelling in bioadhesives. In contrast to current hydrophilic bioadhesives, we here propose an underwater and in-situ applicable hydrophobic adhesive (UIHA). We report polydimethylsiloxane (PDMS) tangled with macromolecular silicone fluid as a dissipation phase to provide strong interface adhesion strength. The silicone fluid repels the surface boundary water layer, overcomes capillary break up in water, and rapidly gelates with PDMS, while a small amount of silane (

公开(公告)号：WO2014161085A1

公开(公告)日：2014-10-09

申请号：PCT/CA2014/050311

申请日：2014-03-26

Applicant: UNIVERSITY OF MANITOBA

Inventor： XING, Malcolm

IPC: A61K47/36 ,  A61K9/10 ,  A61L15/28 ,  A61P17/02

CPC classification number: A61L15/28 ,  A61K9/0014 ,  A61K9/06 ,  A61K47/36 ,  A61K47/61 ,  C08B37/003 ,  C08B37/0072 ,  C08L5/08

Abstract: A wound dressing composition, comprising a flexible pharmaceutically acceptable carrier material, and a hydrogel composition coated onto the flexible pharmaceutically acceptable material. The hydrogel composition comprises an aldehydic hyaluronic acid prepared by modifying a hyaluronic acid with a 1-amino-3, 3-diethoxy-propane, and a chitosan conjugated to the aldehydic hyaluronic acid by a Schiff base linkage. The carrier material may be a woven material comprising natural fibers and/or synthetic fibers. Alternatively, the carrier material may be a polymeric sheet material. The wound dressing composition may additionally comprise one or more of a buffer component, a softening agent, and an antimicrobial composition.

Abstract translation: 包含柔性药学上可接受的载体材料的伤口敷料组合物，以及涂覆在柔性药学上可接受的材料上的水凝胶组合物。 水凝胶组合物包含通过用1-氨基-3,3-二乙氧基 - 丙烷改性透明质酸和通过席夫碱连接与醛透明质酸缀合的壳聚糖制备的醛透明质酸。 载体材料可以是包含天然纤维和/或合成纤维的编织材料。 或者，载体材料可以是聚合物片材。 伤口敷料组合物可另外包含缓冲剂组分，软化剂和抗微生物组合物中的一种或多种。

公开(公告)号：WO2014075186A1

公开(公告)日：2014-05-22

申请号：PCT/CA2013/050872

申请日：2013-11-14

Applicant: UNIVERSITY OF MANITOBA

Inventor： XING, Malcolm

IPC: C12N11/04 ,  A61L27/38 ,  C12N11/02 ,  C12N5/071 ,  C12M3/04

CPC classification number: C12N11/04 ,  C12N5/0068 ,  C12N2533/54 ,  C12N2533/72 ,  C12N2533/74 ,  C12N2535/00 ,  C12N2539/10

Abstract: A method for preparing a layered mammalian-cell compatible nanomembrane, comprising the steps of: (i) grafting a temperature-responsive substrate onto a support substrate having cleaned surfaces; (ii) culturing a layer of selected mammalian cells onto the surface of the temperature-responsive substrate; (iii) depositing a layer of gelatin onto the mammalian cells; (iv) depositing a layer of a cationic polyelectrolyte solution onto the layer of gelatin; (v) depositing a layer of an anionic polyelectrolyte solution onto the cationic polyelectrolyte layer; and (vi) storing the layered mammalian-cell compatible nanomembrane in a fluid storage medium at a temperature wherein the cell layer remains attached to the temperature-responsive substrate. The layered mammalian-cell compatible nanomembrane can be detached from the temperature-responsive substrate by adjusting the temperature of the fluid storage medium to a second temperature. One or more mammalian cell regulatory compounds may be added to the cationic polyelectrolyte solution and/or the anionic polyelectrolyte solution.

Abstract translation: 一种制备层状哺乳细胞相容纳米膜的方法，包括以下步骤：（i）将温度敏感性基底接枝到具有清洁表面的支撑基底上; （ii）将所选择的哺乳动物细胞层培养在温度敏感性基质的表面上; （iii）将明胶层沉积到哺乳动物细胞上; （iv）将阳离子聚电解质溶液层沉积到明胶层上; （v）在阳离子聚电解质层上沉积一层阴离子聚电解质溶液; 和（vi）在细胞层保持附着于温度响应性基质的温度下将分层的哺乳动物细胞相容纳米膜存储在流体储存培养基中。 通过将流体存储介质的温度调节到第二温度，层状的哺乳动物细胞相容的纳米膜可以从温度响应性衬底脱离。 可以将一种或多种哺乳动物细胞调节化合物加入到阳离子聚电解质溶液和/或阴离子聚电解质溶液中。