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公开(公告)号：WO2018223078A1
公开(公告)日：2018-12-06
申请号：PCT/US2018/035718
申请日：2018-06-01
IPC分类号： C07K14/32
CPC分类号： C07K14/32
摘要： Methods for generating synthetic antimicrobial peptides include (i) identifying a peptide fragment of an antimicrobial peptide that includes a cluster of cationic residues and at least about 25% hydrophobic residues, preferably between about 40% – 60% hydrophobic residues and (ii) generating a peptide variant library based on the peptide fragment by varying a hydrophobicity and charge of residues that make up the peptide fragment. Resulting synthetic peptides can include linear synthetic peptide variants of an AS-48-like bacteriocin having increased antimicrobial activity.
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公开(公告)号：WO2018026594A1
公开(公告)日：2018-02-08
申请号：PCT/US2017/043912
申请日：2017-07-26
摘要： There is an urgent need for new antibiotics and antimicrobials to treat and cure acute and chronic infections by bacterial pathogens. Current high-throughput practices, do not account for any specifics in bacterial growth or inhibition. Such approaches inefficiently identify many false positives and false negatives of novel compounds. Additionally, this strategy informs little about biochemical changes resulting from bactericidal exposure. We disclose a Precision Throughput approach that can be used to effectively screen new potential antimicrobials under specialized growth conditions relevant to bacterial pathogenesis. This platform can be used to determine new biology and antimicrobial effects of the pathogens Pseudomonas aeruginosa and Group A Streptoccoccus and determine new metrics for characterizing bactericidal activity by a Precision Throughput approach.
摘要翻译： 目前迫切需要新型抗生素和抗菌剂治疗和治疗细菌性病原体引起的急性和慢性感染。 目前的高通量实践，并没有考虑细菌生长或抑制的任何细节。 这种方法无效识别新化合物的许多假阳性和假阴性。 此外，这种策略对通过杀菌暴露产生的生物化学变化几乎没有什么影响。 我们披露了一种可用于在与细菌发病机理相关的特定生长条件下有效筛选新型潜在抗菌剂的精密生产能力方法。 该平台可用于确定病原体铜绿假单胞菌和A组链球菌的新的生物学和抗微生物作用，并通过精确的生产力方法确定表征杀菌活性的新指标。 / p>
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