公开(公告)号：WO2021235956A2

公开(公告)日：2021-11-25

申请号：PCT/PL2021/050033

申请日：2021-05-20

Applicant: UNIWERSYTET JAGIELLOŃSKI

Inventor： PANEK, Dawid ,  MALAWSKA, Barbara ,  PASIEKA, Anna ,  JOŃCZYK, Jakub ,  WIĘCKOWSKA, Anna ,  GODYŃ, Justyna ,  SZAŁAJ, Natalia ,  BAJDA, Marek ,  SAŁAT, Kinga

IPC: C07C215/28 ,  C07C217/58 ,  C07C233/11 ,  C07C233/62 ,  A61K31/137 ,  A61K31/165 ,  A61P25/28 ,  C07C2601/02 ,  C07C2601/14 ,  C07C2603/18

Abstract: A group of novel 9H-fluorcnc derivatives suitable for the preparation of active substances for the treatment of Alzheimer's disease, in particular as multifunctional inhibitors of the BuChE and BACE1 enzymes and beta-amyloid aggregation.