公开(公告)号：WO2015057461A3

公开(公告)日：2015-06-11

申请号：PCT/US2014059759

申请日：2014-10-08

申请人： US HEALTH

发明人： PFISTER THOMAS D ,  MARRERO ALLISON M ,  PARCHMENT RALPH E ,  DOROSHOW JAMES H

IPC分类号： C07K16/40 ,  C12Q1/48 ,  G01N33/68

CPC分类号： C07K16/40 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C12N5/16 ,  C12N2501/06 ,  C12Q1/485 ,  C12Y207/11001 ,  G01N33/573 ,  G01N33/6896 ,  G01N2333/91205 ,  G01N2440/14 ,  G01N2500/04 ,  G01N2500/10 ,  G01N2800/2814 ,  G01N2800/52

摘要： Monoclonal antibodies that specifically bind ataxia telangiectasia-mutated and RAD3- related kinase phosphorylated at position 1989 (pT1989 ATR), antigen binding fragments, conjugates thereof, and the use of these antibodies, antigen binding fragments and conjugates are disclosed herein. Also disclosed are nucleic acids encoding these antibodies, vectors including these antibodies, and isolated host cells transformed with these nucleic acids and vectors. Methods are also disclosed for using these antibodies, such as to detect pT1989 ATR, or to determine the dose of an agent of use to treat a subject. The antibodies are also of use for identifying ATR inhibitors.

摘要翻译： 本文公开了特异性结合在1989年（pT1989 ATR）磷酸化的共同点毛细血管扩张突变和RAD3相关激酶，抗原结合片段，其缀合物以及这些抗体，抗原结合片段和缀合物的用途的单克隆抗体。 还公开了编码这些抗体的核酸，包括这些抗体的载体和用这些核酸和载体转化的分离的宿主细胞。 还公开了使用这些抗体的方法，例如检测pT1989 ATR或确定用于治疗受试者的药剂的剂量。 抗体也可用于鉴定ATR抑制剂。