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    HUMAN METAPNEUMO VIRUS VACCINE
    1.
    发明申请
    HUMAN METAPNEUMO VIRUS VACCINE 审中-公开

    公开(公告)号：WO2022214678A2

    公开(公告)日：2022-10-13

    申请号：PCT/EP2022/059492

    申请日：2022-04-08

    申请人： VALNEVA SE

    发明人： LUNDBERG, Urban ,  MEINKE, Andreas ,  PERUGI, Fabien

    IPC分类号： A61K39/12 ,  C12N2760/18334

    摘要： The present invention relates to a vaccine composition for preventing and/or treating a respiratory system infection such as a human metapneumovirus infection of the respiratory system. This vaccine composition comprises one, two or more modified human metapneumovirus (hMPV) F proteins or variants thereof provided in a pre-fusion -fusion conformation form.

    METHOD FOR RESCUING AND PRODUCING A VIRUS IN AVIAN CELLS
    3.
    发明申请
    METHOD FOR RESCUING AND PRODUCING A VIRUS IN AVIAN CELLS 审中-公开

    公开(公告)号：WO2020012037A1

    公开(公告)日：2020-01-16

    申请号：PCT/EP2019/069030

    申请日：2019-07-15

    申请人： VALNEVA SE

    发明人： BATARD, Luc ,  FRESLON-EVAIN, Caroline ,  PERUGI, Fabien ,  SCHWAMBORN, Klaus

    IPC分类号： C07K14/005 ,  C12N7/00 ,  C12N15/86

    摘要： The present invention relates to methods of rescue and/or propagation of paramyxovirus species, particularly wherein both rescue and propagation are carried out in the same cell type; i.e., without the use of helper cells for viral rescue. The paramyxoviruses produced by the disclosed methods may encompass wild-type viruses, chimeric viruses, recombinant viruses or engineered viral products such as virus like particles (VLP). Viruses and/or viral products produced in the method according to the current invention are suitable for medical or veterinary use in such applications as treating or preventing infectious diseases, particularly avian paramyxovirus and human respiratory virus infections, and cancer treatment.