公开(公告)号：WO2014015341A3

公开(公告)日：2014-01-23

申请号：PCT/US2013/051523

申请日：2013-07-22

申请人： VANDERBILT UNIVERSITY

发明人： MARNETT, Lawrence, J. ,  PATEL, Sachin ,  HERMANSON, Daniel, J. ,  WINDSOR, Matthew, A.

IPC分类号： A61P29/00 ,  A61K31/19 ,  A61K31/192

摘要： Methods for selectively inhibiting endocannabinoid oxygenation but not arachidonic acid oxygenation. In some embodiments, the methods include contacting a COX-2 polypeptide with an effective amount of a substrate-selective COX-2 inhibitor. Also provided are methods for elevating a local endogenous cannabinoid concentrations; methods of reducing depletion of an endogenous cannabinoid; methods for inducing analgesia; methods of providing anxiolytic therapy; methods for providing anti-depressant therapy; and compositions for performing the disclosed methods.

公开(公告)号：WO2014015341A2

公开(公告)日：2014-01-23

申请号：PCT/US2013/051523

申请日：2013-07-22

申请人： VANDERBILT UNIVERSITY

发明人： MARNETT, Lawrence, J. ,  PATEL, Sachin ,  HERMANSON, Daniel, J. ,  WINDSOR, Matthew, A.

IPC分类号： A61K31/192 ,  A61K31/165

CPC分类号： C07D209/14 ,  A61K31/165 ,  A61K31/192 ,  C07C57/62 ,  C07C59/72 ,  C07C62/38 ,  C07C215/76 ,  C07C233/25 ,  C07C233/27

摘要： Methods for selectively inhibiting endocannabinoid oxygenation but not arachidonic acid oxygenation. In some embodiments, the methods include contacting a COX-2 polypeptide with an effective amount of a substrate-selective COX-2 inhibitor. Also provided are methods for elevating a local endogenous cannabinoid concentrations; methods of reducing depletion of an endogenous cannabinoid; methods for inducing analgesia; methods of providing anxiolytic therapy; methods for providing anti-depressant therapy; and compositions for performing the disclosed methods.

摘要翻译： 选择性抑制内源性大麻素氧合而不是花生四烯酸氧合的方法。 在一些实施方案中，所述方法包括使COX-2多肽与有效量的底物选择性COX-2抑制剂接触。 还提供了用于升高局部内源性大麻素浓度的方法; 减少内源性大麻素消耗的方法; 镇痛方法 提供抗焦虑治疗的方法; 提供抗抑郁药的方法; 和用于执行所公开方法的组合物。