公开(公告)号：WO2021055161A1

公开(公告)日：2021-03-25

申请号：PCT/US2020/048782

申请日：2020-08-31

Applicant: VERILY LIFE SCIENCES LLC

Inventor： GLIK, Eliezer ,  KAVUSI, Sam

IPC: A61B3/12

Abstract: A dynamic illuminator includes a central aperture, a ring of inner light sources, a plurality of primary illumination arrays, and a plurality of secondary illumination arrays. The ring of inner light sources is arranged around the central aperture. The plurality of primary illumination arrays extends along radial axes from the central aperture outside of the ring of inner light sources, wherein the primary illumination arrays each includes a plurality of primary light sources. The plurality of secondary illumination arrays is disposed along secondary axes extending from the central aperture outside of the ring of inner light sources. The secondary illumination arrays each includes a plurality of secondary light sources. The secondary axes of the secondary illumination arrays are disposed angularly between adjacent ones of the primary illumination arrays.

公开(公告)号：WO2020018296A1

公开(公告)日：2020-01-23

申请号：PCT/US2019/040606

申请日：2019-07-03

Applicant: VERILY LIFE SCIENCES LLC

Inventor： GLIK, Eliezer ,  KAVUSI, Sam

IPC: A61B3/12

Abstract: A retinal imaging system includes an image sensor for acquiring a retinal image and a dynamic illuminator for illuminating a retina to acquire the retinal image. The dynamic illuminator includes a center baffle along with first and second illumination arrays. The center baffle extends from and surrounds an aperture through which an image path for the retinal image passes before reaching the image sensor. The first illumination array extends out from first opposing sides of the aperture along a first linear axis. The second illumination array extends out from second opposing sides of the aperture along a second linear axis that is substantially orthogonal to the first linear axis.

公开(公告)号：WO2019036196A1

公开(公告)日：2019-02-21

申请号：PCT/US2018/044849

申请日：2018-08-01

Applicant: VERILY LIFE SCIENCES LLC

Inventor： KRAMER, Ryan ,  KAVUSI, Sam ,  GLIK, Eliezer ,  WU, Honglei

IPC: A61B3/12

Abstract: A technique for retinal images includes configuring a dynamic illuminator to illuminate the retina with an illumination pattern. An image frame of the retina is captured while illuminated with the illumination pattern. The configuring and the capturing are iterated to sequentially reconfigure the dynamic illuminator to illuminate the retina with a plurality of different illumination patterns and to capture a plurality of image frames each illuminated with one of the different illumination patterns. The image frames are combined into a composite retinal image.

公开(公告)号：WO2021133464A1

公开(公告)日：2021-07-01

申请号：PCT/US2020/058297

申请日：2020-10-30

Applicant: VERILY LIFE SCIENCES LLC

Inventor： GLIK, Eliezer ,  KAVUSI, Sam

IPC: A61B3/12 ,  A61B3/14

Abstract: Eye cups and retinal imaging systems including an eye cup are described. In an embodiment, the eye cup is shaped to couple with an eyepiece lens assembly. In an embodiment, the eye cup includes a concave socket shaped to couple to a periorbital region of an eye, the concave socket defining a viewing aperture positioned to align with a pupil of the eye along a longitudinal axis of the viewing aperture when the concave socket is coupled to the periorbital region; and a flange extending from the concave socket away from the longitudinal axis and shaped to couple with a lateral margin of the periorbital region when the concave socket is coupled to the periorbital region. In an embodiment, an outer edge of the flange extends farther from the longitudinal axis than an outer edge of portion of the concave socket.

公开(公告)号：WO2020092089A1

公开(公告)日：2020-05-07

申请号：PCT/US2019/057647

申请日：2019-10-23

Applicant: VERILY LIFE SCIENCES LLC

Inventor： GLIK, Eliezer ,  KAVUSI, Sam

IPC: A61B3/12 ,  A61B3/14

Abstract: A retinal imaging system includes an eyepiece lens assembly, an image sensor, a dynamic fixation target viewable through the eyepiece lens assembly, and a controller coupled to the image sensor and the dynamic fixation target. The controller includes logic that causes the retinal imaging system to perform operations including: acquiring a first image of the eye, analyzing the first image to determine whether a lateral misalignment between the eye and the eyepiece lens assembly is greater than a threshold misalignment, in response to determining the lateral misalignment is greater than the threshold misalignment, adjusting a visual position of the dynamic fixation target to encourage the eye to rotate in a direction that compensates for the lateral misalignment, and acquiring the retinal image of the eye while the eye is encouraged to rotate towards the direction that compensates for the lateral misalignment.

公开(公告)号：WO2019046076A1

公开(公告)日：2019-03-07

申请号：PCT/US2018/047605

申请日：2018-08-22

Applicant: VERILY LIFE SCIENCES LLC

Inventor： LAMBA, Dhruv ,  KAVUSI, Sam

IPC: A61B3/12

Abstract: A method of imaging an interior of an eye includes illuminating the interior of the eye with one or more beams of light from a light source, and said illuminating is configured to trigger a change to a pupil of the eye. An image sensor captures a sequence of images of light reflected by the interior of the eye during an expected timeframe when a width of the pupil is changing in response to said illuminating. A processing apparatus combines images in the sequence of images to form a composite image having a larger depth of field than a depth of field of each of the images in the sequence of images. The depth of field for each of the images corresponds to the width of the pupil when each of the images is captured.

公开(公告)号：WO2018026861A1

公开(公告)日：2018-02-08

申请号：PCT/US2017/044978

申请日：2017-08-01

Applicant: VERILY LIFE SCIENCES LLC

Inventor： KAVUSI, Sam ,  PEPIN, Brian M.

IPC: A61B1/00 ,  A61B1/045 ,  A61B1/05 ,  G02B3/00 ,  H01L27/146

Abstract: Apparatuses and methods for an interposer for integration of multiple image sensors are disclosed herein. An example apparatus includes an interposer including laterally spaced first and second windows, and first and second image sensors disposed on the interposer over the first and second windows, respectively. The interposer including conductive conduits formed in or on to provide electrically conductive paths there through with the first and second image sensors coupled to the conductive conduits. The first and second image sensors laterally spaced by a gap, and an active area of the first and second image sensors to receive incident light through the respective first and second windows, where a perspective of the first image is different than a perspective of the second image sensor based at least in part on the gap.

Abstract translation: 本文公开了用于集成多个图像传感器的内插器的设备和方法。 示例装置包括：中介层，其包括横向间隔开的第一和第二窗口;以及第一和第二图像传感器，其分别在第一和第二窗口上布置在中介层上。 中介层包括导电导管，导电导管形成在其中或其上以提供导电路径，其中第一和第二图像传感器耦合到导电导管。 第一图像传感器和第二图像传感器横向间隔开间隙，并且第一图像传感器和第二图像传感器的有效区域通过相应的第一窗口和第二窗口接收入射光，其中第一图像的透视与第二图像的透视不同 图像传感器至少部分基于差距。

公开(公告)号：WO2019089647A1

公开(公告)日：2019-05-09

申请号：PCT/US2018/058285

申请日：2018-10-30

Applicant: VERILY LIFE SCIENCES LLC

Inventor： KRAMER, Ryan ,  KAVUSI, Sam ,  GLIK, Eliezer ,  LEE, Seung Ah ,  BELTHANGADY, Chinmay

IPC: A61B3/00 ,  A61B3/032

CPC classification number: A61B3/152 ,  A61B3/0008 ,  A61B3/0041 ,  A61B3/0091 ,  A61B3/032 ,  A61B3/112 ,  A61B3/113 ,  A61B3/1225 ,  A61B3/145

Abstract: The technology described herein is directed to a fundus camera and, more specifically, to a fundus camera having a display that projects active visual alignment stimuli onto an eye of an examinee via one or more components of an optimal assembly. The active visual alignment stimuli are dynamically adjusted to guide an examinee toward optical alignment for fundus imaging.

公开(公告)号：WO2021076283A1

公开(公告)日：2021-04-22

申请号：PCT/US2020/052184

申请日：2020-09-23

Applicant: VERILY LIFE SCIENCES LLC

Inventor： WU, Honglei ,  KAVUSI, Sam

IPC: A61B3/12 ,  A61B3/14 ,  G03B15/02 ,  G03B15/14 ,  G06T1/40

Abstract: A technique for imaging a retina with a retinal camera includes illuminating the retina with a plurality of distinct illumination bands that are substantially exclusive of green visible light while substantially not illuminating the retina with the green visible light. A first retinal image is acquired while illuminating the retina with the distinct illumination bands and substantially not illuminating the retina with the green visible light.

公开(公告)号：WO2019060467A1

公开(公告)日：2019-03-28

申请号：PCT/US2018/051826

申请日：2018-09-19

Applicant: VERILY LIFE SCIENCES LLC

Inventor： GLICK, Eliezer ,  KAVUSI, Sam ,  KRAMER, Ryan ,  WHITEHURST, Todd

IPC: A61B3/12 ,  A61B3/14 ,  G02F1/13

Abstract: Introduced here are retinal cameras having optical stops whose size and/or position can be modified to increase the size of the space in which an eye can move while being imaged. In some embodiments, an optical stop is mechanically moved to recover retinal image quality as the subject shifts their eye. In some embodiments, an optical stop is digitally created using a pixelated liquid crystal display (LCD) layer having multiple pixels that are individually controllably. In some embodiments, multiple non-pixelated LCD layers are connected to one another to form a variable transmission stack, and each LCD layer within the variable transmission stack may be offset from the other LCD layers. In such embodiments, the optical stop can be moved by changing which LCD layer is active at a given point in time.