公开(公告)号：WO2016164542A1

公开(公告)日：2016-10-13

申请号：PCT/US2016/026383

申请日：2016-04-07

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： JACKSON, Michael, R. ,  SEITH, Christopher ,  BALA, Senthil ,  FREDETTE, Colin

IPC: G01N33/30 ,  B01D15/16 ,  B01D15/40

CPC classification number: G01N30/84 ,  B01D15/24 ,  B01D15/40 ,  G01N30/30 ,  G01N30/32 ,  G01N30/62 ,  G01N30/80 ,  G01N30/82

Abstract: The present disclosure relates to methodologies, systems and apparatus for cooling a supersaturated or mixed-phase solution to increase the solubility of gases dissolved therein. In a fluid chromatography system, the mobile phase may include a pressurized mixture including a gas, such as C0 2 , and prior to fraction collection and/or detection a portion of the gas is extracted via a gas/liquid separator. Cooling the substantially liquid phase eluent exiting the gas/liquid separator increases the solubility of any remnant gas still dissolved within the eluent. The increased solubility of the remnant gas prevents out gassing, provides more consistent flow of the eluent through the system, and results in more efficient collection and analysis of a desired sample.

Abstract translation: 本公开涉及用于冷却过饱和或混合相溶液以增加溶解于其中的气体的溶解度的方法，系统和设备。 在流体色谱系统中，流动相可以包括含有气体例如CO 2的加压混合物，并且在部分收集和/或检测之前，一部分气体通过气体/ 液体分离器。 冷却离开气/液分离器的基本上液相的洗脱液增加仍然溶解在洗脱液中的任何剩余气体的溶解度。 残余气体的溶解度增加可防止气体析出，提供更一致的流动通过系统的流动，并且导致对所需样品的更有效的收集和分析。

公开(公告)号：WO2014150396A1

公开(公告)日：2014-09-25

申请号：PCT/US2014/023142

申请日：2014-03-11

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： JEANNOTTE, Anthony, C. ,  BASILE, Mark ,  BALA, Senthil ,  FREDETTE, Colin

IPC: G01N21/05 ,  B01D15/08

CPC classification number: G01N21/4133 ,  G01N21/05 ,  G01N30/74 ,  G01N2021/4146

Abstract: The invention provides differential refractive index detectors and methods for the use of differential refractive index detectors. In an exemplary embodiment, a differential refractive index detector includes a flow cell body having a proximal end, a distal end, and a flow axis extending between the proximal and the distal end. The flow cell body includes a first chamber and a second chamber and the fluid conduits coupled to the flow cell body can be tapered to reduce dispersion.

Abstract translation: 本发明提供了使用差示折射率检测器的差分折射率检测器和方法。 在示例性实施例中，差示折射率检测器包括具有近端，远端以及在近端和远端之间延伸的流动轴线的流动池主体。 流动池主体包括第一室和第二室，并且耦合到流动池主体的流体导管可以是锥形的以减少分散。