公开(公告)号：WO2021108591A1

公开(公告)日：2021-06-03

申请号：PCT/US2020/062276

申请日：2020-11-25

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： RAYMOND, Timothy, M. ,  WALDEN, Christopher ,  ANDERSON, Sean

IPC: G01N30/34 ,  F04B7/04 ,  F04B53/00 ,  F04B7/00

Abstract: Disclosed is a gradient proportioning valve for liquid chromatography that includes a plurality of inlet ports configured to receive a plurality of fluids, a manifold connected to each of the plurality of inlet ports configured to mix the plurality of fluids in a controlled manner to provide a fluid composition, the manifold including a plurality of conduits internal to the manifold, each of the plurality of conduits receiving fluid through a respective one of the plurality of inlet ports, an actuation mechanism having a piston located within a bored structure surrounding the piston, the actuation mechanism configured to open and close at least one of the plurality of conduits in a controlled manner where the piston and the bored structure have a tight tolerance configured to create a fluid tight seal, and a common outlet port configured to receive the fluid composition.

公开(公告)号：WO2021108607A1

公开(公告)日：2021-06-03

申请号：PCT/US2020/062297

申请日：2020-11-25

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： RAYMOND, Timothy, M. ,  WALDEN, Christopher ,  ANDERSON, Sean

IPC: G01N30/32 ,  G01N30/34

Abstract: Disclosed is a gradient proportioning valve for liquid chromatography that includes a plurality of inlet ports configured to receive a plurality of fluids, a manifold connected to each of the plurality of inlet ports configured to mix the plurality of fluids in a controlled manner to provide a fluid composition, the manifold including a plurality of fluid conduits internal to the manifold, each of the plurality of fluid conduits receiving fluid through a respective one of the plurality of inlet ports, each of the plurality of fluid conduits operatively communicable to a respective actuation mechanism configured to open and close each of the plurality of fluid conduits in a controlled manner, a common outlet port configured to receive the fluid composition, and a passive fluidic dampening system configured to dampen unwanted fluidic pressure pulses in the manifold where at least one of the plurality of fluid conduits is compliant.

公开(公告)号：WO2021108575A1

公开(公告)日：2021-06-03

申请号：PCT/US2020/062258

申请日：2020-11-25

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： RAYMOND, Timothy, M. ,  WALDEN, Christopher ,  ANDERSON, Sean

IPC: G01N30/34 ,  G01N30/32 ,  F16L55/04

Abstract: Disclosed is a gradient proportioning valve for use in liquid chromatography that includes a plurality of inlet ports configured to receive a plurality of fluids, a manifold connected to each of the plurality of inlet ports configured to mix the plurality of fluids in a controlled manner to provide a fluid composition, the manifold including a plurality of conduits internal to the manifold, each of the plurality of conduits receiving fluid through a respective one of the plurality of inlet ports, each of the plurality of conduits operatively communicable to a respective actuation mechanism configured to open and close each of the plurality of conduits in a controlled manner, a common outlet port configured to receive the fluid composition, and an active fluidic dampening system configured to dampen unwanted fluidic pressure pulses in the manifold. Liquid chromatography systems and methods are further disclosed.