公开(公告)号：WO2015106280A1

公开(公告)日：2015-07-16

申请号：PCT/US2015/011235

申请日：2015-01-13

Applicant: XHALE, INC.

Inventor： MELKER, Richard ,  COHEN, Sean ,  TAN, Huwei

IPC: A61B5/00

CPC classification number: A61B5/0878 ,  A61B5/0205 ,  A61B5/0816 ,  A61B5/0826 ,  A61B5/0836 ,  A61B5/087 ,  A61B5/0871 ,  A61B5/14551 ,  A61B5/6819 ,  A61B5/7221 ,  A61B5/746 ,  A61B2505/03

Abstract: The present invention relates to systems and methods for comparing photoplethysmography (PPG) signals from an individual with signals from a secondaryrespiration sensor secured to the individual to determine whether effective respiration has occurred or whether the individual has apnea, hypopnea, or other respiratory distress.

Abstract translation: 本发明涉及用于比较来自个体的光谱体积描记术（PPG）信号与来自固定到个体的次级呼吸传感器的信号的系统和方法，以确定是否发生有效呼吸或个体是否具有呼吸暂停，呼吸不足或其它呼吸窘迫。

公开(公告)号：WO2015054680A2

公开(公告)日：2015-04-16

申请号：PCT/US2014/060200

申请日：2014-10-11

Applicant: XHALE, INC.

Inventor： MELKER, Richard ,  COHEN, Sean ,  TAN, Huwei

IPC: A61K39/245

CPC classification number: A61B5/7246 ,  A61B5/0205 ,  A61B5/0816 ,  A61B5/0826 ,  A61B5/0836 ,  A61B5/14551 ,  A61B5/6819

Abstract: Provided herein are methods and systems for validating and interpreting respiratory signals in order to provide comprehensive non-invasive methods to monitor patients at risk for respiratory depression and apnea. In the present invention, data from multiple respiratory monitoring technologies (or from multiple channels of one monitoring technology) is fused so that the patient's true respiratory state may be elucidated.

Abstract translation: 本文提供了用于验证和解释呼吸信号的方法和系统，以便提供全面的非侵入性方法来监测呼吸抑制和呼吸暂停风险的患者。 在本发明中，来自多个呼吸监测技术（或来自一个监测技术的多个通道）的数据被融合，使得可以阐明患者的真实呼吸状态。

公开(公告)号：WO2015021036A1

公开(公告)日：2015-02-12

申请号：PCT/US2014/049763

申请日：2014-08-05

Applicant: XHALE, INC.

Inventor： MELKER, Richard

IPC: A61B5/02 ,  A61B5/20 ,  A61B5/1455

CPC classification number: A61B5/0295 ,  A61B5/08 ,  A61B5/0816 ,  A61B5/14552 ,  A61B5/6803 ,  A61B5/6819

Abstract: Provided according to embodiments of the invention are methods for monitoring an individual including securing a photoplethysmography (PPG) sensor comprising at least one emitter and at least one detector onto skin overlying an ophthalmic artery region of the individual; and obtaining PPG signals generated by the PPG sensor. Sensors for photoplethysmographic monitoring at the ophthalmic artery region are also provided.

Abstract translation: 根据本发明的实施例提供的方法是用于监测个体的方法，包括将包含至少一个发射器和至少一个检测器的光电体积描记术（PPG）传感器固定在覆盖在个体的眼动脉区域上的皮肤上; 并获得由PPG传感器产生的PPG信号。 还提供了用于在眼动脉区域进行光电容积监测的传感器。

公开(公告)号：WO2015038852A1

公开(公告)日：2015-03-19

申请号：PCT/US2014/055317

申请日：2014-09-12

Applicant: XHALE, INC.

Inventor： COHEN, Sean ,  MELKER, Richard

IPC: A61M16/01

CPC classification number: A61B5/14551 ,  A61B5/0205 ,  A61B5/02416 ,  A61B5/0816 ,  A61B5/742

Abstract: Provided according to embodiments of the invention are physiological parameter display systems that include a multicolor display unit that includes a primary emitter unit configured to emit a hue at or between a first predetermined hue and a second predetermined hue; a controller in communication with the multicolor display unit, wherein the controller is configured to direct the primary emitter unit to display the first predetermined hue if a blood oxygen saturation value of an individual is at or above a predefined upper limit and to display the second predetermined hue if the blood oxygen saturation value for the individual is at or below a predefined lower limit.

Abstract translation: 根据本发明的实施例提供的生理参数显示系统包括多色显示单元，其包括被配置为在第一预定色调和第二预定色调之间或之间发射色调的主发射器单元; 与所述多色显示单元通信的控制器，其中所述控制器被配置为如果所述个体的血氧饱和度值在等于或高于预定上限并且显示所述第二预定色调，则引导所述主发射器单元显示所述第一预定色调 如果个体的血氧饱和度值处于或低于预定义的下限，则为色调。

公开(公告)号：WO2016100706A1

公开(公告)日：2016-06-23

申请号：PCT/US2015/066449

申请日：2015-12-17

Applicant: XHALE, INC.

Inventor： MELKER, Richard

IPC: A61B5/0295

CPC classification number: A61B5/0295 ,  A61B5/02416 ,  A61B5/0816 ,  A61B5/14551 ,  A61B5/4836 ,  A61B5/4848 ,  A61B5/486 ,  A61B5/6819 ,  A61B5/7275 ,  A61B5/7285 ,  A61B5/742 ,  A61B2505/01 ,  A61H31/005 ,  A61H31/006 ,  A61H31/007 ,  A61H2201/5043 ,  A61H2201/5092 ,  A61H2201/5094 ,  A61H2201/5097 ,  A61H2230/04 ,  A61H2230/207 ,  A61H2230/25 ,  A61H2230/40

Abstract: Provided according to embodiments of the invention are methods of improving the effectiveness of chest compressions as part of cardiopulmonary resuscitation (CPR). Such methods include monitoring PPG signals from a PPG sensor secured to a nose during at least one chest compression and increasing, decreasing or maintaining a at least one of the depth, duration and frequency of at least one subsequent chest compression based on a waveform parameter of the PPG signals. Related devices and systems are also provided.

Abstract translation: 根据本发明的实施例提供的是提高作为心肺复苏（CPR）的一部分的胸部按压的有效性的方法。 这样的方法包括在至少一次胸部压缩期间监测来自固定到鼻部的PPG传感器的PPG信号，并且基于波形参数增加，减少或维持至少一个后续胸部按压的深度，持续时间和频率中的至少一个 PPG信号。 还提供了相关的设备和系统。

公开(公告)号：WO2015195872A1

公开(公告)日：2015-12-23

申请号：PCT/US2015/036360

申请日：2015-06-18

Applicant: XHALE, INC.

Inventor： RICH, David ,  KERSEY, Andrew ,  COHEN, Sean ,  MELKER, Richard

IPC: A61B5/0205

CPC classification number: A61B5/14551 ,  A61B5/08 ,  A61B2562/225

Abstract: Provided according to embodiments of the invention are systems for monitoring a physiological state of an individual that include a PPG sensor, which optionally includes an auxiliary physiological sensor integrated with or connected thereto; a first signal processing device in electronic communication with the PPG sensor, whereby the PPG sensor transmits PPG signals to the first signal processing device; and a second signal processing device that detects at least a portion of the signals transmitted by the PPG sensor to the first signal processing device, at least a portion of signals transmitted by the auxiliary physiological sensor, or both. Related methods are also provided herein.

Abstract translation: 根据本发明的实施例提供的是用于监视个体的生理状态的系统，其包括PPG传感器，其可选地包括与其集成或连接的辅助生理传感器; 与PPG传感器电子通信的第一信号处理装置，由此PPG传感器将PPG信号传输到第一信号处理装置; 以及第二信号处理装置，其将由PPG传感器发送的信号的至少一部分检测到第一信号处理装置，由辅助生理传感器发送的信号的至少一部分或两者。 本文还提供了相关方法。