公开(公告)号：WO1996037576A1

公开(公告)日：1996-11-28

申请号：PCT/US1996007283

申请日：1996-05-20

Applicant: XYTRONYX, INC.

Inventor： XYTRONYX, INC. ,  ALFEKRI, Dheya

IPC: C09K09/02

CPC classification number: C09K9/02

Abstract: The present invention provides for light fatigue resistant photochromic compositions including a unique combination of hindered aminoether light stabilizer ("HAELS") compounds to extend the usable lifetime of naphthopyran photochromic compositions and articles. Additionally, light stabilizer compounds and hydroxyphenyl benzotriazole UV absorbers have a synergistic effect in extending the usable lifetime of photochromic compositions and articles. Specifically, certain tertiary and secondary amine HALS compounds in combination with hydroxyphenyl benzotriazole UV absorbers extend the usable lifetime of spiro-indolino-oxazine photochromic compositions and articles. Similarly, aminoether HAELS compounds in combination with hydroxyphenyl benzotriazole UV absorbers further extend the usable lifetime of the naphthopyran photochromic compositions and articles.

Abstract translation: 本发明提供了耐疲劳光致变色组合物，其包括受阻氨基醚光稳定剂（“HAELS”）化合物的独特组合，以延长萘并吡喃光致变色组合物和制品的使用寿命。 此外，光稳定剂化合物和羟基苯基苯并三唑UV吸收剂在延长光致变色组合物和制品的使用寿命方面具有协同效应。 具体地，某些叔胺和仲胺HALS化合物与羟基苯基苯并三唑UV吸收剂的组合延长了螺 - 吲哚啉 - 恶嗪光致变色组合物和制品的使用寿命。 类似地，氨基醚HAELS化合物与羟基苯基苯并三唑UV吸收剂的组合进一步延长了萘并吡喃光致变色组合物和制品的使用寿命。

公开(公告)号：WO1994023062A1

公开(公告)日：1994-10-13

申请号：PCT/US1994003413

申请日：1994-03-29

Applicant: XYTRONYX, INC.

Inventor： XYTRONYX, INC. ,  ODSTRCHEL, Gerald ,  LEUNG, George

IPC: C12Q01/52

CPC classification number: C12Q1/52 ,  Y10S435/808 ,  Y10S435/81

Abstract: Method for determining the presence of an aminotransferase (AT1), other than aspartate aminostransferase (AST), in a biological sample. The method includes contacting the sample with an amino donor substrate for AT1, an amino acceptor substrate for AT1, cysteine sulfinic acid (CSA) in excess, a second aminotransferase (AT2), different from AT1, in excess, and an indicator for the presence of sulfite ions, under conditions in which the concentration of said AT1 can be determined by the amount of the indicator which forms a detectable signal.

Abstract translation: 用于确定生物样品中除天冬氨酸氨基转移酶（AST）之外的氨基转移酶（AT1）的存在的方法。 该方法包括将样品与AT1的氨基供体底物，AT1的氨基受体底物，过量的半胱氨酸亚磺酸（CSA），过量的与AT1不同的第二氨基转移酶（AT2）和用于存在的指示剂 的亚硫酸根离子，其中所述AT1的浓度可以由形成可检测信号的指示剂的量确定。

公开(公告)号：WO1994001503A1

公开(公告)日：1994-01-20

申请号：PCT/US1993006142

申请日：1993-06-29

Applicant: XYTRONYX, INC.

Inventor： XYTRONYX, INC. ,  GOMAN, Peter, M. ,  SIRDESAI, Sunil

IPC: C09D11/02

CPC classification number: C09D11/50

Abstract: A phototranschromic ink suitable for use in a printing machine, including a water soluble, inert, non-ionic polymeric resin carrier base having film forming properties, a photo acid or photo base progenitor which releases or takes up protons upon exposure to light, a pH sensitive dye which changes color in response to a change in proton levels, a water compatible non-ionic wetting agent which cooperates with said dye to allow said dye to change color in response to said change in proton levels, a water compatible non-ionic thickening agent which cooperates with said dye to allow said dye to change color in response to said change in proton levels, a neutral water soluble flow aid which cooperates with said dye to allow said dye to change color in response to said change of proton levels; wherein said base, progenitor, dye, wetting agent, thickening agent and flow aid all cooperate to provide an ink which changes color upon exposure to ultraviolet radiation and is of suitable consistency for use in a printing machine.

Abstract translation: 适用于印刷机的光致变色油墨，包括具有成膜性能的水溶性，惰性，非离子聚合物树脂载体基质，曝光时释放或吸收质子的光酸或光碱类祖细胞，pH 敏感染料，其响应于质子水平的变化而改变颜色，与水相容的非离子润湿剂，其与所述染料配合以允许所述染料响应于质子水平的变化而改变颜色，水相容的非离子增稠 其与所述染料配合以允许所述染料响应于所述质子水平的变化而改变颜色;中性水溶性流动助剂，其与所述染料配合以允许所述染料响应于质子水平的变化而改变颜色; 其中所述碱，前体，染料，润湿剂，增稠剂和流动助剂全部配合以提供在暴露于紫外线辐射时改变颜色并且具有适用于印刷机的稠度的油墨。

公开(公告)号：WO1990013669A1

公开(公告)日：1990-11-15

申请号：PCT/US1990002633

申请日：1990-05-11

Applicant: XYTRONYX, INC.

Inventor： XYTRONYX, INC. ,  BARAM, Peter ,  MULLIS, Kary, Banks

IPC: C12Q01/68

CPC classification number: C12Q1/6895

Abstract: A process for detecting the presence of a Pneumocystis carinii infection in a mammal is described in which Pneumocystis carinii encoded nucleic acids are detected in the blood of an infected mammal by means of nucleic acid hybridization, preferably using a polymerase chain reaction.

Abstract translation: 描述了一种用于检测哺乳动物卡氏肺囊虫感染存在的方法，其中通过核酸杂交，优选使用聚合酶链式反应，在感染的哺乳动物的血液中检测卡氏肺囊虫编码的核酸。

公开(公告)号：WO1990013670A1

公开(公告)日：1990-11-15

申请号：PCT/US1990002632

申请日：1990-05-11

Applicant: XYTRONYX, INC.

Inventor： XYTRONYX, INC. ,  HOFFMAN, John, W. ,  WOODRING, Cynthia, S.

IPC: C12Q01/70

CPC classification number: C07K16/14 ,  C07K14/37

Abstract: The present invention describes methods and systems for detecting the presence of Pneumocystis carinii antigens in the blood. Also disclosed and useful in both methods and systems of the present invention is a monoclonal antibody immunospecific for a 116kD Pneumocystis carinii antigen and antigenically cross-reactive fragments thereof.

Abstract translation: 本发明描述了用于检测血液中卡氏肺囊虫抗原存在的方法和系统。 在本发明的方法和系统中也公开并且有用的是针对116kD卡氏肺囊虫抗原和抗原交叉反应性片段免疫特异性的单克隆抗体。

公开(公告)号：WO1987005633A1

公开(公告)日：1987-09-24

申请号：PCT/US1987000541

申请日：1987-03-16

Applicant: XYTRONYX, INC.

Inventor： XYTRONYX, INC. ,  BABLER, Scott, D. ,  BARAM, Peter ,  RUDOLPH, Paul, H. ,  WAXMAN, Frank, J.

IPC: C12Q01/36

CPC classification number: C12Q1/52 ,  Y10S435/81

Abstract: Improvements in methods for determining the presence of suprathreshold amounts of aspartate aminotransferase in an oral fluid sample by (1) incubation of aspartate aminotransferase substrate materials in a first reaction mixture with the sample to form a first reaction product and (2) detection of reaction product therein by incubation with an indicator substance in a second reaction mixture wherein a second colored reaction product is formed. The improvement comprises (a) utilizing a diazonium dyestuff as the indicator substance in the second reaction and (b) modifying reaction conditions within the first and second reaction mixtures such that no visually detectable colored reaction product will be formed in the second reaction mixture by subthreshold level of aspartate aminotransferase but wherein a visually detectable color reaction product will be formed in the reaction mixture when a selected suprathreshold concentration of aspartate aminotransferase is present in the first reaction mixture.

Abstract translation: （1）将第一反应混合物中的天冬氨酸氨基转移酶底物材料与样品孵育以形成第一反应产物和（2）检测反应产物，从而改进口腔液样品中阈值量的天冬氨酸氨基转移酶的存在的方法 其中通过与指示物质在第二反应混合物中温育，其中形成第二有色反应产物。 改进包括（a）在第二反应中利用重氮染料作为指示物质，和（b）改变第一和第二反应混合物内的反应条件，使得在第二反应混合物中不会通过亚阈值形成视觉上可检测的有色反应产物 水平的天冬氨酸氨基转移酶，但是当在第一反应混合物中存在选择的阈值浓度的天冬氨酸氨基转移酶时，其中将在反应混合物中形成视觉上可检测的显色反应产物。

公开(公告)号：WO1994019416A1

公开(公告)日：1994-09-01

申请号：PCT/US1994001866

申请日：1994-02-22

Applicant: XYTRONYX, INC.

Inventor： XYTRONYX, INC. ,  SIRDESAI, Sunsil, J. ,  ODSTRCHEL, Gerald

IPC: C09D11/00

CPC classification number: C09D11/50

Abstract: Photochromic ink comprising a spiroheterocycle or metal dithiozonate photochromic dye.

Abstract translation: 包含螺杂环或金属二硫代锡酮光致变色染料的光致变色油墨。

公开(公告)号：WO1990009589A1

公开(公告)日：1990-08-23

申请号：PCT/US1990000211

申请日：1990-01-17

Applicant: XYTRONYX, INC.

Inventor： XYTRONYX, INC. ,  BARAM, Peter

IPC: G01N33/535

CPC classification number: C12Q1/48 ,  G01N33/573 ,  Y10S435/805 ,  Y10S435/81

Abstract: Disclosed are methods for determining the presence of periodontal disease in mammals. The methods include the steps of (1) sampling gingival crevicular fluid, (2) assaying the crevicular fluid sample by colorimetric or other means to determine levels of alanine aminotransferase present, and (3) correlating the levels of alanine aminotransferase present in the crevicular fluid sample with a standard which is indicative of the presence of periodontal disease.

公开(公告)号：WO1988007222A1

公开(公告)日：1988-09-22

申请号：PCT/US1988000710

申请日：1988-03-16

Applicant: XYTRONYX, INC.

Inventor： XYTRONYX, INC. ,  MULLIS, Kary, Banks

IPC: G03C01/727

CPC classification number: G01J1/50 ,  G03C1/73

Abstract: Photochemical systems for the visualization of exposure to ultraviolet radiation and for the utilization of ultraviolet radiation to effectuate visible color changes involving a process responsive to ultraviolet radiation in which a photoacid is formed upon irradiation of a photoacid progenitor compound, preferably 0-nitrobenzaldehyde, with ultraviolet light and wherein proton transfer to a dyestuff causes the dyestuff to undergoe a visible color change. If desired, the system undergoes such color changes to an extent directly proportional to the cumulative amount of ultraviolet incident thereupon. Examples are given of materials which can be made into films, extruded into fibers, formed into objects, or formulated as inks, paints, and the like.