公开(公告)号：WO2018185760A1

公开(公告)日：2018-10-11

申请号：PCT/IL2018/050390

申请日：2018-04-03

申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD.

发明人： STRAUSSMAN, Ravid ,  GAVERT, Nancy

IPC分类号： C12N5/07 ,  G01N33/50

摘要： Ex-vivo culture systems are provided. Accordingly there is provided a culture system comprising a culture medium and a precision-cut tissue slice placed on a tissue culture insert, wherein the precision-cut tissue slice is maintained in a highly oxygenated atmosphere containing at least 50 % oxygen and wherein said culture is rotationally agitated facilitating intermittent submersion of the tissue slice in the culture medium. Also provided are methods of culturing a tissue and methods of using the culture system for selecting a drug for the treatment of a disease.

公开(公告)号：WO2023031925A1

公开(公告)日：2023-03-09

申请号：PCT/IL2022/050947

申请日：2022-08-30

申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  THE MEDICAL RESEARCH, INFRASTRUCTURE AND HEALTH SERVICES FUND OF THE TEL AVIV MEDICAL CENTER

发明人： STRAUSSMAN, Ravid ,  GAVERT, Nancy ,  ZWANG, Yaara

IPC分类号： A61K31/4184 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K45/06 ,  A61P35/00

摘要： A method of treating colorectal cancer (CRC) is provided. The method comprises administering to a subject in need thereof a therapeutically effective amount of a Mitogen/extracellular signal-regulated kinase (MEK) inhibitor and a SRC Proto-Oncogene, Non¬ Receptor Tyrosine Kinase (SRC) inhibitor, wherein cancer cells of the subject express an amount of SRC p419 above a predetermined level and do not express a KRAS G12 mutation, thereby treating the CRC.

公开(公告)号：WO2019145964A1

公开(公告)日：2019-08-01

申请号：PCT/IL2019/050115

申请日：2019-01-29

申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD.

发明人： STRAUSSMAN, Ravid ,  GAVERT, Nancy

IPC分类号： A61K31/135 ,  A61K31/519 ,  A61K45/06 ,  A61K31/164 ,  A61K31/166 ,  A61K31/18 ,  A61K31/416 ,  A61K31/4184 ,  A61K31/44 ,  A61K31/4523 ,  A61K31/506 ,  A61P35/04 ,  A61P35/00

CPC分类号： A61P35/00 ,  A61K31/135 ,  A61K31/164 ,  A61K31/166 ,  A61K31/18 ,  A61K31/416 ,  A61K31/4184 ,  A61K31/44 ,  A61K31/4523 ,  A61K31/506 ,  A61K31/519 ,  A61K45/06 ,  A61P35/04 ,  A61K2300/00

摘要： Methods of treating sarcoma are provided. Accordingly, there is provided a method of treating sarcoma in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a Mitogen-activated protein kinase kinase (MEK) inhibitor and a CDK4/6 inhibitor.