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公开(公告)号：WO2009053741A3
公开(公告)日：2010-01-21
申请号：PCT/GB2008050978
申请日：2008-10-22
Applicant: YORK PHARMA PLC , SCHMIDTS THOMAS M , RUNKEL FRANK
Inventor： SCHMIDTS THOMAS M , RUNKEL FRANK
IPC: A61K9/70
CPC classification number: A61K9/0017 , A61K31/506 , A61K31/57 , A61K47/10 , A61K47/12
Abstract: The present invention relates to a pharmaceutical formulation comprising a pharmaceutically activeagent; water; a polyethylene glycol or a poloxamer; and a polyethylene glycol mono- or di-ether. Preferably the pharmaceutically active agent is an anti-fungal or anti-mycotic agent. Preferably the pharmaceutically active agent is lipophilic and/or keratinophilic. The present invention also relates to the use of the formulation in treating diseases, disorders or pathological conditions of the nail or skin, such as onychomycosis, dermatomycosis and other mycoses. The present invention also relates to a method of administering a pharmaceutically active agent to a subject by applying the formulation comprising the pharmaceutically active agent to a nail or skin of the subject. The present invention further relates to a method of preparing the formulation.
Abstract translation: 本发明涉及药物制剂，其包含药学上可接受的药物; 水; 聚乙二醇或泊洛沙姆; 和聚乙二醇单醚或二醚。 优选地，药物活性剂是抗真菌剂或抗真菌剂。 优选地，药物活性剂是亲脂性和/或角质参与的。 本发明还涉及该制剂用于治疗指甲或皮肤的疾病，病症或病理状况，例如甲真菌病，皮肤真菌病和其它真菌病。 本发明还涉及通过将包含药学活性剂的制剂施用于受试者的指甲或皮肤来向受试者施用药物活性剂的方法。 本发明还涉及制备该制剂的方法。
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2.发明申请
公开(公告)号：WO2011098285A8
公开(公告)日：2011-12-29
申请号：PCT/EP2011000648
申请日：2011-02-11
Applicant: STERNA BIOLOG GMBH & CO KG , SCHMIDTS THOMAS , GARN HOLGER , RUNKEL FRANK
Inventor： SCHMIDTS THOMAS , GARN HOLGER , RUNKEL FRANK
CPC classification number: C12N15/113 , A61K9/0014 , A61K9/1075 , A61K9/113 , C12N2310/11 , C12N2310/127
Abstract: The invention relates to a cosmetic and/or dermatological and/or pharmaceutical composition for the topical use and application of oligonucleotides, in particular antisense-oligonucleotides such as DNAzyme, siRNAs, asDNAs or ribozymes for use as an agent against inflammatory diseases by means of emulsions having a dispersed, internal, discontinuous aqueous phase.
Abstract translation: 本发明通过具有分散的，内部的，不连续的乳液涉及化妆品和/或皮肤病学和或药物组合物用于局部施用和寡核苷酸的应用，尤其是反义寡核苷酸如DNA核酶，siRNA的，asDNAs或核酶用作炎性疾病的补救措施 水相。
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3.发明申请USE OF A MEDICINE CONTAINING A QUANTITY OF TYROTHRICINE FOR THE TREATMENT OF VIRAL INFECTIONS 审中-公开使用产品含短杆菌素用于治疗病毒感染的治疗
公开(公告)号：WO9961011A3
公开(公告)日：2000-01-13
申请号：PCT/EP9903539
申请日：1999-05-22
Applicant: KARL ENGELHARD FABRIK PHARM PR , RUNKEL FRANK
Inventor： RUNKEL FRANK
IPC: A61K35/74
CPC classification number: A61K38/12 , A61K31/4425 , A61K2300/00
Abstract: The invention relates to new uses of a medicine containing a quantity of tyrothricine, including the treatment of infections with viruses of the family Poxviridae, especially infections with the molluscum contagiosum virus.
Abstract translation: 有含药短杆菌素的提出了新的用途，包括治疗感染的药物与家人痘病毒的病毒，传染性软疣病毒感染特别。
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4.发明申请
公开(公告)号：WO2011098285A3
公开(公告)日：2012-04-19
申请号：PCT/EP2011000648
申请日：2011-02-11
Applicant: STERNA BIOLOG GMBH & CO KG , SCHMIDTS THOMAS , GARN HOLGER , RUNKEL FRANK
Inventor： SCHMIDTS THOMAS , GARN HOLGER , RUNKEL FRANK
CPC classification number: C12N15/113 , A61K9/0014 , A61K9/1075 , A61K9/113 , C12N2310/11 , C12N2310/127
Abstract: The invention relates to a cosmetic and/or dermatological and/or pharmaceutical composition for the topical use and application of oligonucleotides, in particular antisense-oligonucleotides such as DNAzyme, siRNAs, asDNAs or ribozymes for use as an agent against inflammatory diseases by means of emulsions having a dispersed, internal, discontinuous aqueous phase.
Abstract translation: 本发明通过具有分散的，内部的，不连续的乳液涉及化妆品和/或皮肤病学和或药物组合物用于局部施用和寡核苷酸的应用，尤其是反义寡核苷酸如DNA核酶，siRNA的，asDNAs或核酶用作炎性疾病的补救措施 水相。
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