公开(公告)号：WO2023076424A2

公开(公告)日：2023-05-04

申请号：PCT/US2022/047932

申请日：2022-10-26

Applicant: ZENG, Wei-ping

Inventor： ZENG, Wei-ping

IPC: A61K45/06 ,  A61P35/00 ,  A61P35/04 ,  A61K31/4706 ,  A61K31/133 ,  A61K31/14

Abstract: This invention focuses on the cellular differences in response to pH alterations and a key role of the cells' proliferative statuses in determining their responses. Therefore, methods and compositions are designed to use pH modifiers and cell proliferation inhibitors to treat or prevent diseases with pathogenesis attributable to inflammation, immune response, cell proliferation, or combinations thereof. The pH modifiers, particularly but not exclusively those that lower or resist the rise of pH, are used to deplete pathological inflammatory and/or proliferating cells. Conversely, pH modifiers that raise or resist the fall of pH are used to increase the population and the proliferation of normal protective cells.