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    IMPROVED MUCOSAL DELIVERY OF VITAMIN B12
    3.
    发明申请
    IMPROVED MUCOSAL DELIVERY OF VITAMIN B12 审中-公开
    维生素B12的改进的粘膜递送

    公开(公告)号：WO2016199165A3

    公开(公告)日：2017-02-09

    申请号：PCT/IN2016050168

    申请日：2016-06-04

    申请人： ZIM LABORATORIES LTD

    发明人： DAUD ANWAR ,  SAPKAL NIDHI ,  DAUD LUBNA ,  BONDE MINAL

    IPC分类号： C07H23/00

    CPC分类号： A61K31/714 ,  A61K9/006 ,  A61K9/2013 ,  A61K9/205

    摘要： This invention comprises a method of transmucosal delivery of process of Vitamin B 12 without the need of intrinsic factor comprising administering a solid composition comprising a Vitamin B 12 and at least one bifunctional macromolecule with hydrophilic exterior and with hydrophobic pockets capable of pocketing Vitamin B12 material,, illustrated by cyclodextrin, at least one permeation enhancer, illustrated by Isopropyl Myristate and at least one agent that is mucoadhessive as well as penetration enhancer, illustrated by chitosan. The solid composition of Vitamin B 12 of claim 2 may comprise a lozenge, a candy, a wafer, a tablet, a patch, a film, a spray, a lip balm, or gum.

    摘要翻译： 本发明包括不需要内在因子的维生素B12的经粘膜递送方法，其包括施用含有维生素B12和至少一种双功能大分子的固体组合物，所述固体组合物具有亲水性外部和疏水口袋，所述疏水口袋能够渗透维生素B12材料， 由环糊精说明的至少一种渗透促进剂，由肉豆蔻酸异丙酯和至少一种粘膜白血病剂以及渗透促进剂所示，由壳聚糖所示。 权利要求2的维生素B12的固体组合物可以包含锭剂，糖果，晶片，片剂，贴剂，膜，喷雾剂，唇膏或胶。

    BITTER TASTE-MASKED, ONDANSETRON ORALLY DISINTEGRATING FILM
    7.
    发明申请
    BITTER TASTE-MASKED, ONDANSETRON ORALLY DISINTEGRATING FILM 审中-公开
    BITTER TASTE-MASKED，ONDANSETRON ORALLY DISCAMIC FILM

    公开(公告)号：WO2016052960A1

    公开(公告)日：2016-04-07

    申请号：PCT/KR2015/010238

    申请日：2015-09-25

    申请人： SEOUL PHARMA. CO., LTD.

    发明人： LEE, Jin Hoo ,  KIM, Hyun Soo ,  KIM, Jung Hoon

    IPC分类号： A61K9/70 ,  A61K47/02 ,  A61K47/38 ,  A61K31/4178

    CPC分类号： A61K31/4178 ,  A61K9/0056 ,  A61K9/2009 ,  A61K9/2018 ,  A61K9/2031 ,  A61K9/205 ,  A61K9/2054

    摘要： Disclosed herein are an orally disintegrating film composition comprising ondansetron, magnesium oxide or magnesium hydroxide, and a film forming agent, an orally disintegrating film made thereof, and a method for preparing the orally disintegrating film. The orally disintergrating film according to the present invention can be prepared without using an additional complicated process. Further, the ondansetron orally disintegrating film is provided with suitable physical properties, and effectively masks the bitter taste of ondansetron.

    摘要翻译： 本文公开了包含昂丹司琼，氧化镁或氢氧化镁和成膜剂，其制成的口腔崩解膜的口腔崩解膜组合物和制备口腔崩解膜的方法。 根据本发明的口服去结晶膜可以在不使用额外的复杂工艺的情况下制备。 此外，昂丹司琼口腔崩解膜具有合适的物理性能，有效地掩盖了昂丹司琼的苦味。

    HYDROGELS OF METHACRYLIC HYALURONIC ACID DERIVATIVES FOR ORAL ENZYME THERAPY IN CELIAC DISEASE
    10.
    发明申请
    HYDROGELS OF METHACRYLIC HYALURONIC ACID DERIVATIVES FOR ORAL ENZYME THERAPY IN CELIAC DISEASE 审中-公开
    甲基丙烯酸羟脯氨酸衍生物用于口腔疾病口腔治疗的水解

    公开(公告)号：WO2015169849A1

    公开(公告)日：2015-11-12

    申请号：PCT/EP2015/059941

    申请日：2015-05-06

    申请人： NEMYSIS LIMITED

    发明人： PITARRESI, Giovanna ,  PALUMBO, Fabio Salvatore ,  GIAMMONA, Gaetano

    IPC分类号： A61K47/36 ,  A61K9/19 ,  A61K9/20 ,  C08B37/08 ,  A61K38/43

    CPC分类号： A61K47/36 ,  A61K9/0053 ,  A61K9/06 ,  A61K9/19 ,  A61K9/205 ,  A61K38/482 ,  A61K47/14 ,  A61K47/18 ,  A61K47/26 ,  C08B37/0072 ,  C08J3/24 ,  C08J3/28 ,  C08J2305/08 ,  C08L5/08 ,  C12Y304/21026

    摘要： The present invention relates to a composition comprising hydrogels from functionalized hyaluronic acid derivatives, said hydrogels loaded with exogenous enzymes selected in the group consisting of prolyl endopeptidase (PEP) and endoprotease (EP)intended for the oral treatment of celiac disease. Specifically, this invention concerns a one-pot methodology useful to prepare methacrylic derivatives of hyaluronic acid, through the formation of a specific active group on hydroxyl groups of hyaluronic acid, the subsequent substitution of the inserted active group with ethylenediamine and finally, the reaction with methacrylic anhydride. The obtained methacrylic hyaluronic acid derivatives are used to prepare hydrogels through irradiation and loaded with exogenous enzymes selected in the group consisting of prolyl endopeptidase (PEP) and endoprotease (EP). The ability of prepared hydrogels to allow the enzyme release, as active form in simulated gastrointestinal fluids is proved.

    摘要翻译： 本发明涉及包含来自官能化透明质酸衍生物的水凝胶的组合物，所述水凝胶装载有选自用于口腔治疗乳糜泻的脯氨酰内肽酶（PEP）和内切蛋白酶（EP）的外源性酶。 具体而言，本发明涉及通过在透明质酸的羟基上形成特定的活性基团，随后用乙二胺替代插入的活性基团，最后与...的反应，可用于制备透明质酸的甲基丙烯酸衍生物的一锅法 甲基丙烯酸酐。 所得甲基透明质酸衍生物用于通过照射制备水凝胶并加载选自脯氨酰内肽酶（PEP）和内切蛋白酶（EP）的外源酶。 证明了制备的水凝胶允许酶释放作为模拟胃肠液中活性形式的能力。