公开(公告)号：WO2018213140A1

公开(公告)日：2018-11-22

申请号：PCT/US2018/032417

申请日：2018-05-11

Applicant: ZENO ROYALTIES & MILESTONES, LLC

Inventor： HOPKINS, Chad, Daniel ,  PINCHMAN, Joseph, Robert ,  BUNKER, Kevin, Duane ,  SLEE, Deborah, Helen ,  BOREN, Brant, Clayton ,  KAHRAMAN, Mehmet

IPC: C07D277/28 ,  C07C211/41 ,  C07C217/56 ,  C07C235/14 ,  C07D239/26 ,  C07D213/38 ,  C07D277/64 ,  C07D263/56 ,  C07D235/14 ,  C07C211/19 ,  C07C211/25 ,  C07C233/14 ,  C07C271/24 ,  C07D277/78

Abstract: Disclosed herein are compounds of Formulae (la), (lb), (Ic), (Id), (le), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It), methods of synthesizing compounds of Formulae (la), (lb), (Ic), (Id), (le), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It), and methods of using compounds of Formulae (la), (lb), (Ic), (Id), (le), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It) as an analgesic.

公开(公告)号：WO2019023481A1

公开(公告)日：2019-01-31

申请号：PCT/US2018/043935

申请日：2018-07-26

Applicant: ZENO ROYALTIES & MILESTONES, LLC

Inventor： HUANG, Peter, Qinhua ,  SLEE, Deborah, Helen ,  BUNKER, Kevin, Duane ,  HEGDE, Sayee, Gajanan ,  HOPKINS, Chad, Daniel

IPC: C07C59/56 ,  C07C255/57 ,  A61K31/192 ,  A61P35/00 ,  A61P5/32

Abstract: Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as breast cancer.

公开(公告)号：WO2019173082A1

公开(公告)日：2019-09-12

申请号：PCT/US2019/019557

申请日：2019-02-26

Applicant: ZENO ROYALTIES & MILESTONES, LLC

Inventor： HUANG, Peter, Qinhua ,  BUNKER, Kevin, Duane ,  BOREN, Brant, Clayton ,  HEGDE, Sayee, Gajanan ,  LIU, Hui ,  UNNI, Aditya, Krishnan ,  ABRAHAM, Sunny ,  HOPKINS, Chad, Daniel ,  PALIWAL, Sunil

IPC: C07D471/04 ,  A61P35/00 ,  A61K31/519

Abstract: Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as breast cancer.

公开(公告)号：WO2017205459A8

公开(公告)日：2017-11-30

申请号：PCT/US2017/034163

申请日：2017-05-24

Applicant: ZENO ROYALTIES & MILESTONES, LLC

Inventor： BUNKER, Kevin, Duane ,  HUANG, Peter, Qinhua ,  ABRAHAM, Sunny ,  PINCHMAN, Joseph, Robert ,  HOPKINS, Chad, Daniel ,  SLEE, Deborah, Helen

IPC: C07D403/14 ,  C07D209/04 ,  A61K31/404 ,  A61P35/00

Abstract: Disclosed herein are nitrogen-containing bicyclic compounds, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer described herein with one or more of the compounds described herein.