公开(公告)号：WO9931131A3

公开(公告)日：1999-07-29

申请号：PCT/US9826940

申请日：1998-12-18

Applicant: ZYMOGENETICS INC

Inventor： SHEPPARD PAUL O ,  MOORE EMMA E ,  RAYMOND FENELLA C

IPC: C12N15/09 ,  C07K14/575 ,  C07K14/585 ,  C07K16/26 ,  C07K16/42 ,  C12P21/02 ,  C12P21/08 ,  C12N15/16 ,  C12Q1/68

CPC classification number: C07K14/575

Abstract: Mammalian Zcalc1 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies.

Abstract translation: 哺乳动物Zcalc1多肽，编码多肽的多核苷酸，以及包括抗体和抗独特型抗体的相关组合物和方法。

公开(公告)号：WO0042183A2

公开(公告)日：2000-07-20

申请号：PCT/US0001902

申请日：2000-01-18

Applicant: ZYMOGENETICS INC

Inventor： SHEPPARD PAUL O ,  NOVAK JULIA E ,  RAYMOND FENELLA C

IPC: C07K14/47 ,  C12N15/12 ,  C07K14/82 ,  C07K16/32 ,  C12Q1/68 ,  G01N33/574

CPC classification number: C07K14/4703

Abstract: Studies indicate that mutations in tumor suppressor genes occur early in the process of carcinogenesis, and that these mutations are correlated with a subsequent development of cancer. The detection of such alterations would provide useful molecular markers for diagnosis, surveillance, early tumor identification and intervention, and prognosis. A novel human gene, designated as "Zsig62", resides within a region of chromosome 16q that is associated with prostate and breast cancer, and that appears to contain tumor suppressor genes. Like a tumor suppressor gene, the Zsig62 gene is expressed in particular normal tissues, but not in tumors derived from those tissues.

Abstract translation: 研究表明，肿瘤抑制基因突变在致癌过程的早期发生，这些突变与随后的癌症发展相关。 这种改变的检测将为诊断，监测，早期肿瘤鉴定和干预以及预后提供有用的分子标记。 称为“Zsig62”的新型人类基因位于与前列腺和乳腺癌相关的染色体16q的区域中，并且似乎含有肿瘤抑制基因。 像肿瘤抑制基因一样，Zsig62基因在特定的正常组织中表达，但不是来源于那些组织的肿瘤。