中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

61 records (took 0.016 seconds)

    PEPTIDE AND POLYPEPTIDE INHIBITORS OF COMPLEMENT C1S
    4.
    发明申请
    PEPTIDE AND POLYPEPTIDE INHIBITORS OF COMPLEMENT C1S 审中-公开
    肽和多肽抑制剂补体C1S

    公开(公告)号：WO0198365A3

    公开(公告)日：2003-07-03

    申请号：PCT/US0119405

    申请日：2001-06-18

    Applicant: ZYMOGENETICS INC

    Inventor： WEST ROBERT R ,  SHEPPARD PAUL O ,  FOX BRIAN A

    IPC: A61K38/00 ,  A61P29/00 ,  A61P31/00 ,  C07K14/435 ,  C07K14/815 ,  A61K38/58

    CPC classification number: C07K14/815 ,  A61K38/00 ,  C07K14/43536

    Abstract: The complement system plays an important role in providing resistance to infections and in the pathogenesis of tissue injury. Yet an inappropriate activation of complement can result in a variety of disorders. The present invention provides C1s catalytic site-directed moieties, C1s exosite binding moieties, and bivalent polypeptide inhibitors comprising such moieties, which can be used to treat conditions characterized by inappropriate complement activation.

    Abstract translation: 补体系统在提供抗感染和组织损伤的发病机制中起重要作用。 然而补体的不适当活化可导致多种疾病。 本发明提供C1s催化位点定向部分，C1s外部结合部分和包含这些部分的二价多肽抑制剂，其可用于治疗以不适当补体活化为特征的病症。

    CUB DOMAIN PROTEIN ZCUB3 AND MATERIALS AND METHODS FOR MAKING IT
    5.
    发明申请
    CUB DOMAIN PROTEIN ZCUB3 AND MATERIALS AND METHODS FOR MAKING IT 审中-公开
    CUB域蛋白ZCUB3及其制备材料及方法

    公开(公告)号：WO02059317A2

    公开(公告)日：2002-08-01

    申请号：PCT/US0202298

    申请日：2002-01-23

    Applicant: ZYMOGENETICS INC

    Inventor： FOX BRIAN A ,  TAFT DAVID W ,  SHEPPARD PAUL O

    IPC: C07K14/47 ,  C12N15/12 ,  C07K14/705 ,  C07K16/28 ,  C07K19/00

    CPC classification number: C07K14/47 ,  C07K2319/00 ,  C12N2799/022

    Abstract: Novel polypeptides, materials and methods for making them, and method of use are disclosed. The polypeptides comprise at least fifteen contiguous amino acid residues of SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:7, or SEQ ID NO:9 and may be prepared as polypeptide fusions comprise hetelologous sequences, such as affinity tags. The polypeptides and polynucletodes encoding them may be used within a variety of therapeutic, diagnostic, and research applications.

    Abstract translation: 公开了新颖的多肽，制备它们的材料和方法以及使用方法。 多肽包含SEQ ID NO：3，SEQ ID NO：5，SEQ ID NO：7或SEQ ID NO：9的至少十五个连续氨基酸残基，并且可以制备为多肽融合物，其包含嗜碱性序列，例如亲和标签 。 可以在各种治疗，诊断和研究应用中使用编码它们的多肽和多核苷酸。

    "> HUMAN MEMBRANE ASSOCIATED PROTEIN
    7.
    发明申请
    HUMAN MEMBRANE ASSOCIATED PROTEIN "ZSIG24" AND ENCODING GENE AS MARKER FOR METABOLIC DISEASE 审中-公开
    人膜​​相关蛋白“ZSIG24”和编码基因作为代谢疾病的标记

    公开(公告)号：WO0024767A3

    公开(公告)日：2000-08-10

    申请号：PCT/US9924662

    申请日：1999-10-20

    Applicant: ZYMOGENETICS INC

    Inventor： SHEPPARD PAUL O ,  JELINEK LAURA J ,  WHITMORE THEODORE E

    IPC: C07K14/47 ,  C07K14/705 ,  G01N33/50 ,  G01N33/566

    CPC classification number: C07K14/4713

    Abstract: The present invention provides methods for identifying abnormalities in human chromosome (11) that are linked to defects in glucose metabolism. The present invention also provides methods for identifying polymorphisms in a new human gene that resides on chromosome 11q23-q24, a locus linked with a heritable form of diabetes.

    Abstract translation: 本发明提供用于鉴定与人体染色体（11）中与葡萄糖代谢缺陷相关的异常的方法。 本发明还提供了用于鉴定位于染色体11q23-q24上的新人类基因中的多态性的方法，该基因座与可遗传的糖尿病形式相关联。

    METHODS OF PRODUCING HYBRID G PROTEIN-COUPLED RECEPTORS
    9.
    发明申请
    METHODS OF PRODUCING HYBRID G PROTEIN-COUPLED RECEPTORS 审中-公开
    产生杂合G蛋白偶联受体的方法

    公开(公告)号：WO9112273A3

    公开(公告)日：1991-10-03

    申请号：PCT/US9100909

    申请日：1991-02-08

    Applicant: ZYMOGENETICS INC

    Inventor： SLEDZIEWSKI ANDRZEJ Z ,  SHEPPARD PAUL O

    IPC: C07K14/00 ,  C07K14/37 ,  C07K14/395 ,  C07K14/41 ,  C07K14/705 ,  C07K19/00 ,  C12N1/19 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12R1/85 ,  C12R1/865 ,  C07K13/00 ,  C12G1/02

    CPC classification number: C07K14/705

    Abstract: Methods are disclosed for producing hybrid G protein-coupled receptors. DNA sequences encoding hybrid G protein-coupled receptors are provided, wherein the receptors comprise mammalian G protein-coupled receptors having at least one domain other than the ligand-binding domain replaced with a corresponding domain of a yeast G protein-coupled receptor. DNA constructs comprising the following operatively linked elements: a transcriptional promoter, a DNA sequence encoding a hybrid G protein-coupled receptor, wherein the receptor comprises a mammalian G protein-coupled receptor having at least one domain other than the ligand-binding domain replaced with a corresponding domain of a yeast G protein-coupled receptor, and a transcriptional terminator. Host cells transformed with the DNA constructs and methods utilizing the transformed cells are also provided.

    Abstract translation: 公开了产生杂合G蛋白偶联受体的方法。 提供了编码杂合G蛋白偶联受体的DNA序列，其中所述受体包含哺乳动物G蛋白偶联受体，所述哺乳动物G蛋白偶联受体具有除酵母G蛋白偶联受体的相应结构域替代的配体结合结构域以外的至少一个结构域。 包含以下可操作地连接的元件的DNA构建体：转录启动子，编码杂合G蛋白偶联受体的DNA序列，其中所述受体包含哺乳动物G蛋白偶联受体，所述哺乳动物G蛋白偶联受体具有至少一个不同于所述配体结合结构域的结构域， 酵母G蛋白偶联受体的相应结构域和转录终止子。 还提供了用DNA构建体转化的宿主细胞和利用转化细胞的方法。

    THROMBIN ACTIVATOR COMPOSTIONS AND METHODS OF MAKING AND USING THE SAME
    10.
    发明申请
    THROMBIN ACTIVATOR COMPOSTIONS AND METHODS OF MAKING AND USING THE SAME 审中-公开
    硫酚激活剂组合物及其制备和使用方法

    公开(公告)号：WO2009126616A3

    公开(公告)日：2010-01-07

    申请号：PCT/US2009039757

    申请日：2009-04-07

    Applicant: ZYMOGENETICS INC ,  BISHOP PAUL D ,  POWNDER TRACEY A ,  SHEPPARD PAUL O ,  STENLAND CHRISTOPHER J

    Inventor： BISHOP PAUL D ,  POWNDER TRACEY A ,  SHEPPARD PAUL O ,  STENLAND CHRISTOPHER J

    IPC: C07K17/00

    CPC classification number: C12N9/6418 ,  C07K2319/50

    Abstract: Disclosed are compositions for activating thrombin precursors to thrombin. The compositions provided include polypeptide compositions wherein the pre-pro-sequence comprises a thrombin cleavage site. The compositions provided also include polynucleotides encoding said polypeptides and recombinant systems for expressing said polypeptides. This disclosure also relates to methods for producing said compositions, recovering said compositions, activating said compositions purifying said compositions and producing active thrombin molecules using the active form of said compositions.

    Abstract translation: 公开了用于激活凝血酶凝血酶前体的组合物。 提供的组合物包括多肽组合物，其中前序列包含凝血酶切割位点。 提供的组合物还包括编码所述多肽的多核苷酸和用于表达所述多肽的重组系统。 本公开还涉及生产所述组合物的方法，回收所述组合物，使用所述组合物的活性形式活化所述组合物来纯化所述组合物并产生活性凝血酶分子。

Patent Agency Ranking