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公开(公告)号：WO2021211807A1
公开(公告)日：2021-10-21
申请号：PCT/US2021/027437
申请日：2021-04-15
Applicant: ENTECH INSTRUMENTS INC.
Inventor： CARDIN, Daniel B.
Abstract: A flow controller for filling evacuated canisters can be operated at different reference pressures to produce substantially the same flow rates to facilitate inertness testing of the flow controller through demonstrated recovery of trace level chemicals in a challenge standard prior to using the flow controllers to collect air samples for measurement of VOCs during time weighted sampling events. The flow controller can include a first chamber and a second chamber divided by a diaphragm. The first chamber can be fluidly coupled to an inlet of the flow controller and an outlet of the flow controller. The second chamber can be coupled to a reference port of the flow controller. The outlet of the flow controller can be coupled to an initially (e.g., substantially) evacuated canister that can be used to collect a sample of ambient air or challenge standard (e.g., during testing).
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公开(公告)号：WO2020028441A1
公开(公告)日：2020-02-06
申请号：PCT/US2019/044252
申请日：2019-07-30
Applicant: ENTECH INSTRUMENTS INC.
Inventor： CARDIN, Daniel B.
Abstract: A hybrid trap including a replaceable open-tubular capillary trap followed by a packed trap is used to collect, preconcentrate, and recover a sample, such as VOCs and SVOCs found in air. The capillary stage prevents losses and carryover of the heavy fraction and can also collect the particles in air that contain the heavier SVOCs, also preventing them from reaching the packed stage. The packed stage traps lighter organic compounds that are not as prone to carryover due to channeling. The capillary and packed traps together provide quantitative recovery of compounds boiling from as low as -50 ⁰C to as high as 600 ⁰C. The sample can be directly desorbed onto the GC column, which avoids losses and contamination caused by other approaches that thermally desorb samples through transfer lines and rotary valves more remote to the GC oven.
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公开(公告)号：WO2019084039A1
公开(公告)日：2019-05-02
申请号：PCT/US2018/057151
申请日：2018-10-23
Applicant: ENTECH INSTRUMENTS INC.
Inventor： CARDIN, Daniel B.
CPC classification number: B01L3/502 , B01L2300/0838 , B01L2300/18 , G01N1/2214 , G01N1/405 , G01N1/44 , G01N30/08 , G01N30/12 , G01N30/14 , G01N30/20 , G01N30/30 , G01N30/461 , G01N30/6078 , G01N30/7206 , G01N2001/4033 , G01N2030/121
Abstract: The disclosed system and method concentrates and enriches a chemical sample while removing water and/or CO2 prior to analysis, improving detection limits and repeatability of quantitative chemical analysis without the need for cryogenic or sub-ambient cooling. The system can include a valve system, a dewpomt control zone, and a multi-capillary column trapping system (MCCTS). During a first time period, the valve system can couple the dewpoint control zone to the MCCTS. During a second time period, the valve system can couple the MCCTS to the chemical separation column such the dewpoint control zone is bypassed. Excess water included in the sample can condense in the dewpoint control zone as the sample transfers to the dewpoint control zone and MCCTS. When the sample is transferred from the MCCTS to the chemical separation column, the condensed water in the dewpoint control zone is not transferred to a chemical separation column.
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公开(公告)号：WO2020247539A1
公开(公告)日：2020-12-10
申请号：PCT/US2020/035980
申请日：2020-06-03
Applicant: ENTECH INSTRUMENTS INC.
Inventor： CARDIN, Daniel B.
Abstract: While sample extraction device including a sorbent is coupled to a sample vial containing a sample, a vacuum is drawn through the sample extraction device to evaporate the volatile matrix of the sample and carry volatilized target compounds of the sample to the sorbent. Optionally, once the volatile matrix is evaporated, the sample vial is heated and/or the vacuum level is increased to transfer heavier target compounds to the sorbent. Multiple sampling devices can be extracted in parallel. The sample extraction device can be inserted into a thermal desorption device that directly couples the sample extraction device to a gas chromatograph. In some embodiments, the sample is desorbed and analyzed using gas chromatography or another suitable technique. The techniques disclosed herein are used for analysis of volatile organic compounds and semi-volatile organic compounds in water, food, beverages, soils, and other matrices.
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5.发明申请
公开(公告)号：WO2018191758A1
公开(公告)日：2018-10-18
申请号：PCT/US2018/027838
申请日：2018-04-16
Applicant: ENTECH INSTRUMENTS INC.
Inventor： CARDIN, Daniel B.
CPC classification number: G01N30/54 , G01N30/12 , G01N30/461 , G01N30/468 , G01N30/6017 , G01N30/7206 , G01N2030/025 , G01N2030/128
Abstract: A system to thermally desorb a sample into a multi-column GC or GC/MS system that can use both the desorption system and GC system for optimizing injection rates, matrix management (e.g., water elimination), optimizing recovery of a specific range of chemicals, and system cleanup is described. Reversing the flow through a first column (332) inside the GC can facilitate the elimination of excess, condensed water as well as heavy chemicals that could otherwise affect the operation and background of the GC. The elimination of flow through both the thermal desorber (320) and a first column (332) in the GC during sample preheat can accommodate the pre-expansion of the sample that could otherwise result in pre-release to the active carrier gas flow in other systems. Transfer lines and rotary valves can be avoided, improving system performance and longevity, with simple maintenance achieved by replacing a desorption liner (322) and the first GC column (332).
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Patent Agency Ranking
公开(公告)号：WO2018013946A1
公开(公告)日：2018-01-18
申请号：PCT/US2017/042172
申请日：2017-07-14
Applicant: ENTECH INSTRUMENTS INC.
Inventor： CARDIN, Daniel, B.
IPC: G01N30/06 , G01N1/10 , G01N1/40 , G01N30/00 , G01N33/487 , G01N33/497 , G01N30/88
CPC classification number: G01N30/06 , G01N1/10 , G01N1/405 , G01N33/487 , G01N33/497 , G01N2001/2244 , G01N2001/2276 , G01N2001/4061 , G01N2030/009 , G01N2030/065 , G01N2030/8813
Abstract: A sample extraction device and a desorption device for use in gas chromatography (GC), gas chromatography-mass spectrometry (GCMS), liquid chromatography (LC), and/or liquid chromatography-mass spectrometry (LCMS) are disclosed. In some examples, the sample extraction device includes a lower chamber holding a sorbent. The sample extraction device can extract sample headspace gas from a sample vial by placing the sorbent inside the vial and creating a vacuum to increase recovery of low volatility compounds, for example. Once the sample has been collected, the sample extraction device can be inserted into a desorption device. The desorption device can control the flow of a carrier fluid (e.g., a liquid or a gas) through the sorbent containing the sample and into a pre-column and/or a primary column of a chemical analysis device for performing GC, GCMS, LC, LCMS, and/or some other chemical analysis process.
Abstract translation: 用于气相色谱（GC），气相色谱 - 质谱（GCMS），液相色谱（LC）和/或液相色谱 - 质谱（LCMS）的样品提取装置和解吸装置 ）被披露。 在一些示例中，样品提取装置包括容纳吸附剂的下室。 例如，样品提取装置可通过将吸附剂放置在小瓶内并产生真空以提高低挥发性化合物的回收率，从样品小瓶中提取样品顶空气体。 样品收集后，样品提取装置可以插入解吸装置。 解吸装置可以控制载体流体（例如液体或气体）通过含有样品的吸附剂流入化学分析装置的预柱和/或主柱，用于执行GC，GCMS，LC ，LCMS和/或一些其他化学分析过程。
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公开(公告)号：WO2022251882A1
公开(公告)日：2022-12-01
申请号：PCT/US2022/072637
申请日：2022-05-28
Applicant: ENTECH INSTRUMENTS INC.
Inventor： CARDIN, Daniel B.
IPC: G01N1/24 , G01N1/22 , G01N1/40 , G01N1/44 , G01N33/497
Abstract: A hybrid gas sampling device (100) can combine the functionality of both whole air and sorbent based samplers. The sampling device can be used for collecting light to very heavy organic compounds, for subsequent thermal desorption into a GC or GCMS for quantitative measurement. The sampling device isolates collected samples of gas phase matrices in a sample vessel (132), provided with sorbent elements (202, 256a, 256b, 256c) from a removable sample extraction device (150). The sampling device is operated by drawing a vacuum on the chamber through the sample extraction device after sampling, and then completing the extraction of the heavier organic compounds using a static, diffusive extraction under vacuum to allow optimal deposition of the heavier compounds on the sorbent. The vacuum container is cooled to draw any excess water (450) back into the container, thereby dehydrating attached sorbent element(s) (202, 256a, 256b, 256c) in preparation for thermal desorption into a GC or GCMS, eliminating interferences in the MS analyzer.
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公开(公告)号：WO2020086913A1
公开(公告)日：2020-04-30
申请号：PCT/US2019/057963
申请日：2019-10-24
Applicant: ENTECH INSTRUMENTS INC.
Inventor： CARDIN, Daniel B.
Abstract: Pressure-controlled splitting can be used to inject a chemical sample from an injection source to a detector (e.g., a mass spectrometer) for chemical analysis (e.g., gas chromatography or gas chromatography-mass spectrometry) with reduced peak widths. For example, the sample is first transferred to a first compression volume; then pressure in the system is increased to compress the sample to split it between a second compression volume and a column. The fraction of the sample split to the column can have reduced peak widths compared to the peak widths prior to compression and splitting yet can maintain the same peak height to preserve high sensitivity for trace level analysis. This portion of the sample can traverse the column and elute to the detector for analysis with reduced chemical noise. Faster injection rates can allow faster analysis times, as less separation of chemicals is needed before the sample reaches the detector.
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公开(公告)号：WO2019173501A1
公开(公告)日：2019-09-12
申请号：PCT/US2019/020995
申请日：2019-03-06
Applicant: ENTECH INSTRUMENTS INC.
Inventor： CARDIN, Daniel B.
IPC: A61B5/097
Abstract: A sample collection device collects Volatile Organic Compounds (VOCs) in exhaled breath in the outlet of a breathing assisted ventilator. The sample collection device is attached to the ventilator outlet line through a coupler containing either two check valves, or a check valve and a restrictive outlet flow path. During sampling, the exhaled air flows through a sorbent contained in the sample collection device as the ventilator pressure increases and decreases during the assisted breathing process. The flow of the exhaled air through the sample collection system is driven by the alternating pressure in the ventilator line without the need for an additional pump or power supply separate from the ventilator pump and power supply. The sample collection device can be used to monitor levels of bacteria-produced VOCs as an early detection of pneumonia and to allow feedback on the effectiveness of antibiotic treatment.
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10.发明申请
公开(公告)号：WO2022035983A1
公开(公告)日：2022-02-17
申请号：PCT/US2021/045578
申请日：2021-08-11
Applicant: ENTECH INSTRUMENTS INC.
Inventor： CARDIN, Daniel B.
Abstract: Techniques disclosed herein can improve the extraction of chemicals prior to analysis by GC or GCMS. A liquid or solid sample can be placed in a sample container of a closed system under vacuum that further includes a sample extraction device. The assembly can be placed in a 3-zone heater that can separately control the temperature of the bottom of the sample container, the top of the sample container, and the sample extraction device. Vapor flux from the bottom of the sample container into the headspace of the sample container can deliver compounds of interest to the sample extraction device, whereas matrix compounds can re-condense in the headspace of the sample container to avoid delivery to the sample extraction device. Extraction can continue until substantial transfer of compounds of interest to the sorbent occurs, followed by thermal desorption of the extract into a GCMS for analysis.
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