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    COMPOSITIONS, METHODS AND KITS FOR TREATMENT OF DIABETES AND/OR HYPERLIPIDEMIA
    3.
    发明申请
    COMPOSITIONS, METHODS AND KITS FOR TREATMENT OF DIABETES AND/OR HYPERLIPIDEMIA 审中-公开
    用于治疗糖尿病和/或高脂药物的组合物，方法和工具

    公开(公告)号：WO2016049236A1

    公开(公告)日：2016-03-31

    申请号：PCT/US2015/051793

    申请日：2015-09-23

    Applicant: NUSIRT SCIENCES, INC.

    Inventor： ZEMEL, Michael ,  BRUCKBAUER, Antje

    IPC: A61K9/48

    CPC classification number: A61K31/28 ,  A61K31/05 ,  A61K31/155 ,  A61K31/198 ,  A61K31/36 ,  A61K31/455 ,  A61K31/706 ,  A61K45/06 ,  A61K2300/00

    Abstract: Compositions, methods and kits for treatment of diabetes and/or hyperlipidemia are provided herein. Such compositions can contain synergizing amounts of leucine and/or one or more leucine metabolites in combination with nicotinic acid, nicotinamide riboside and/or nicotinic acid metabolites, and with at least one or more anti-diabetic agents. Such compositions can contain sub-therapeutic amounts of nicotinic acid, nicotinamide riboside and/or nicotinic acid metabolites, and/or sub-therapeutic amounts of one or more anti-diabetic agents that can achieve the same therapeutic efficacy as therapeutic amounts of said compositions in diabetes and/or hyperlipidemia medicaments. The composition can also reduce the side effects associated with treatment using anti-diabetic agents and/or nicotinic acid.

    Abstract translation: 本文提供了用于治疗糖尿病和/或高脂血症的组合物，方法和试剂盒。 这样的组合物可以包含与烟酸，烟酰胺核苷和/或烟酸代谢物以及与至少一种或多种抗糖尿病药物组合的协同量的亮氨酸和/或一种或多种亮氨酸代谢物。 这样的组合物可以包含次治疗量的烟酸，烟酰胺核苷和/或烟酸代谢物，和/或亚治疗量的一种或多种抗糖尿病药，其可以达到与治疗量相同的治疗功效， 糖尿病和/或高脂血症药物。 组合物还可以减少与使用抗糖尿病剂和/或烟酸的治疗相关的副作用。

    COMPOSITIONS, METHODS, AND KITS FOR REGULATING ENERGY METABOLISM
    7.
    发明申请
    COMPOSITIONS, METHODS, AND KITS FOR REGULATING ENERGY METABOLISM 审中-公开
    用于调节能量代谢的组合物，方法和试剂盒

    公开(公告)号：WO2013134736A1

    公开(公告)日：2013-09-12

    申请号：PCT/US2013/030044

    申请日：2013-03-08

    Applicant: NUSIRT SCIENCES, INC. ,  ZEMEL, Michael ,  GRINDSTAFF II, E., Douglas

    Inventor： ZEMEL, Michael ,  GRINDSTAFF II, E., Douglas

    IPC: A61K38/54

    CPC classification number: A61K31/4415 ,  A23L33/15 ,  A23L33/175 ,  A23V2002/00 ,  A61K31/155 ,  A61K31/191 ,  A61K31/194 ,  A61K31/198 ,  A23V2200/332 ,  A23V2250/0628 ,  A23V2250/7052 ,  A61K2300/00

    Abstract: The present invention provides for compositions, methods and kits for regulating energy metabolism. In one aspect, the invention provides for compositions that comprise a combination of (a) branched chain amino acids, such as leucine, and (b) vitamin B6, or any precursors or metabolites of (a) or (b). These combinations may be synergistic and/or effective for reducing weight or adipose volume. In another aspect, the invention provides for methods of regulating energy metabolism by the administration of one or more compositions comprising branched chain amino acids and vitamin B6. The invention also provides for kits comprising compositions of branched chain amino acids and vitamin B6 packaged in an oral dose form with usage instructions.

    Abstract translation: 本发明提供了用于调节能量代谢的组合物，方法和试剂盒。 一方面，本发明提供了包含（a）支链氨基酸如亮氨酸和（b）维生素B6或（a）或（b）的任何前体或代谢物的组合的组合物。 这些组合对于减轻体重或脂肪体积可以是协同的和/或有效的。 另一方面，本发明提供了通过施用包含支链氨基酸和维生素B6的一种或多种组合物来调节能量代谢的方法。 本发明还提供了包含以使用说明书口服剂量形式包装的支链氨基酸和维生素B6的组合物的试剂盒。

    NITROGEN OXIDE DONORS AND USES THEREOF
    9.
    发明申请
    NITROGEN OXIDE DONORS AND USES THEREOF 审中-公开
    氧化氮供体及其用途

    公开(公告)号：WO2018045335A1

    公开(公告)日：2018-03-08

    申请号：PCT/US2017/049946

    申请日：2017-09-01

    Applicant: NUSIRT SCIENCES, INC.

    Inventor： ZEMEL, Michael ,  BRUCKBAUER, Antje ,  BANERJEE, Jheelam

    IPC: A61K31/22 ,  A61K31/23

    CPC classification number: A61K31/495 ,  A61K31/04 ,  A61K31/155 ,  A61K31/196 ,  A61K31/198 ,  A61K31/401 ,  A61K31/4439 ,  A61K31/455 ,  A61K2300/00

    Abstract: Methods useful for reducing or preventing non-alcoholic steatohepatitis or hepatic steatosis are provided herein. Such methods may comprise administering to a subject in need thereof a nitric oxide (NO) donor, a branched amino acid in free amino acid form, or a metabolite thereof, a sirtuin pathway activator, a PDE5 inhibitor alone or any combination thereof. Also provided herein are compositions and kits for practicing any of the methods described herein.

    Abstract translation: 本文提供了用于减少或预防非酒精性脂肪性肝炎或肝脂肪变性的方法。 此类方法可包括向需要其的受试者施用一氧化氮（NO）供体，游离氨基酸形式的支链氨基酸或其代谢物，单独的sirtuin通路活化剂，PDE5抑制剂或其任何组合。 本文还提供用于实施本文所述任何方法的组合物和试剂盒。

    TREATMENT OF PETS WITH SIRTUIN ACTIVATORS
    10.
    发明申请
    TREATMENT OF PETS WITH SIRTUIN ACTIVATORS 审中-公开
    用SIRTUIN激活剂处理PETS

    公开(公告)号：WO2014149280A1

    公开(公告)日：2014-09-25

    申请号：PCT/US2014/016592

    申请日：2014-02-14

    Applicant: NUSIRT SCIENCES, INC.

    Inventor： ZEMEL, Michael ,  BRUCKBAUER, Antje

    IPC: A61K31/00 ,  A61K31/198 ,  A61P3/08

    CPC classification number: A61K31/198 ,  A23K10/18 ,  A23K10/30 ,  A23K20/10 ,  A23K20/142 ,  A23K20/158 ,  A23K20/174 ,  A23K40/30 ,  A23K50/40 ,  A61K31/05 ,  A61K31/202 ,  A61K31/205 ,  A61K31/355 ,  A61K31/375 ,  A61K31/385 ,  A61K31/7008 ,  A61K31/726 ,  A61K33/32 ,  A61K35/741 ,  A61K36/28 ,  A61K36/61 ,  A61K36/9068 ,  A61K45/06 ,  A61K2035/115 ,  A61K2300/00

    Abstract: The present invention provides for systems, compositions, methods and kits for regulating energy metabolism in pets. The systems, compositions, and kits can comprise, and methods can make use of, pet foods, pet treats, pet supplements, and pet drinks. In one aspect, the invention provides for pet food, treat, supplement, and drink compositions that comprise a combination of (a) leucine, and (b) a sirtuin activator, or any precursors or metabolites of (a) or (b). These combinations may be effective for reducing weight or adipose volume in the pet. In another aspect, the invention provides for methods of regulating energy metabolism by the administration of one or more compositions comprising leucine, a leucine metabolite, and/or a sirtuin activator. The invention also provides for kits comprising compositions of leucine, a leucine metabolite, and/or a sirtuin activator packaged in an oral dose form with usage instructions.

    Abstract translation: 本发明提供了用于调节宠物能量代谢的系统，组合物，方法和试剂盒。 系统，组合物和试剂盒可以包括宠物食品，宠物食品，宠物补充剂和宠物饮料的方法和方法。 一方面，本发明提供包含（a）亮氨酸和（b）沉默调节蛋白的活化剂或（a）或（b）的任何前体或代谢物的组合的宠物食品，治疗，补充和饮料组合物。 这些组合对于减轻宠物的体重或脂肪体积是有效的。 另一方面，本发明提供了通过施用包含亮氨酸，亮氨酸代谢物和/或沉默调节蛋白酶活化剂的一种或多种组合物来调节能量代谢的方法。 本发明还提供包含亮氨酸，亮氨酸代谢物和/或以使用说明书以口服剂型形式包装的沉默调节蛋白酶活化剂的组合物的试剂盒。

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