公开(公告)号：WO2015159296A1

公开(公告)日：2015-10-22

申请号：PCT/IL2015/050410

申请日：2015-04-16

Applicant: DIGMA MEDICAL LTD.

Inventor： BEN OREN, Ilan ,  YANIV, Irit ,  WOLF, Tamir ,  HERSCHKOVITZ, Avia

IPC: A61B18/18 ,  A61B6/00

CPC classification number: A61B18/22 ,  A61B1/012 ,  A61B5/0066 ,  A61B5/0086 ,  A61B5/015 ,  A61B5/026 ,  A61B5/055 ,  A61B5/1076 ,  A61B5/4255 ,  A61B6/00 ,  A61B8/085 ,  A61B8/12 ,  A61B8/445 ,  A61B18/02 ,  A61B18/26 ,  A61B2018/00029 ,  A61B2018/00273 ,  A61B2018/00285 ,  A61B2018/00434 ,  A61B2018/00494 ,  A61B2018/00577 ,  A61B2018/00589 ,  A61B2018/00601 ,  A61B2018/00702 ,  A61B2018/00714 ,  A61B2018/00744 ,  A61B2018/00779 ,  A61B2018/00785 ,  A61B2018/00809 ,  A61B2018/00904 ,  A61B2018/00982 ,  A61B2018/0212 ,  A61B2018/20359 ,  A61B2018/2261 ,  A61B2018/2266 ,  A61B2018/2277 ,  A61B2018/2283 ,  A61B2090/061 ,  A61B2090/3735 ,  A61B2090/378 ,  A61B2218/001 ,  A61B2505/05 ,  A61M25/10 ,  A61M2025/1013 ,  A61N5/0603 ,  A61N5/062 ,  A61N5/0625 ,  A61N7/00 ,  A61N2005/063 ,  A61N2005/0659 ,  A61N2007/003 ,  A61N2007/0043

Abstract: The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking occurs through use of ultrasound energy. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves by means of shielding it from the effects of laser radiation. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.

Abstract translation: 根据一些实施方案，本公开提供了用于选择性地减少，阻断或抑制受试者器官中的至少一部分神经活性的方法和系统。 在优选实施方案中，所述方法和系统用于选择性阻断需要其的受试者的十二指肠中的至少一部分神经活性。 根据一些实施例，通过使用激光辐射发生选择性阻塞。 根据一些实施例，通过使用超声能量发生选择性阻塞。 根据一些实施例，选择性阻塞包括对位于目标区域内的感觉神经的至少部分造成损伤，同时通过屏蔽激光辐射的作用来保持围绕感觉神经的组织的功能活动。 根据一些实施例，感觉神经包括被配置为传送由通过十二指肠的食物触发的信号的神经元，例如但不限于神经激素信号。

公开(公告)号：WO0242719A3

公开(公告)日：2002-08-22

申请号：PCT/US0144008

申请日：2001-11-21

Applicant: GEN HOSPITAL ,  ANDERSON R ROX ,  DOMANKEVITZ YACOV

Inventor： ANDERSON R ROX ,  DOMANKEVITZ YACOV

IPC: G02B6/42 ,  A61B18/12 ,  A61B18/20 ,  A61B18/22 ,  A61N5/06 ,  B23K26/08 ,  H01S3/00 ,  H01S3/10

CPC classification number: A61B18/203 ,  A61B2018/00452 ,  A61B2018/2277

Abstract: The invention features systems and tools for controlling the optical penetration depth (OPD) of laser energy, e.g., when delivering laser energy to target tissue in a patient. The systems and tools control the OPD by controlling the incident angle at which the laser energy (364) is delivered to the target area of the patient. Embodiments of the invention include an optical coupler (368) that permits a user to vary the incident angle and thereby selectably control the OPD of incident laser energy (364). Fabricating the optical coupler (368) to have a refractive index greater than that of the target tissue can enhance the range of selectable OPDs. The laser energy (364), which is delivered to the desired depth, can cause alteration of the target tissue by, e.g., heating, ablation, and/or photochemical reaction.

Abstract translation: 本发明的特征在于用于控制激光能量的光穿透深度（OPD）的系统和工具，例如，当将激光能量递送至患者中的目标组织时。 系统和工具通过控制激光能量（364）被传递到患者的目标区域的入射角来控制OPD。 本发明的实施例包括允许用户改变入射角并由此可选择地控制入射激光能量（OP）的光学耦合器（368）（364）。 制造光学耦合器（368）以具有大于目标组织的折射率的折射率可以增强可选择的OPD的范围。 传递到期望深度的激光能量（364）可以通过例如加热，消融和/或光化学反应引起靶组织的改变。

公开(公告)号：WO1990005562A1

公开(公告)日：1990-05-31

申请号：PCT/US1989005127

申请日：1989-11-16

Applicant: MEDILASE, INCORPORATED

Inventor： MEDILASE, INCORPORATED ,  FINN, Miles, A.

IPC: A61N05/01

CPC classification number: A61B18/245 ,  A61B2018/2277

Abstract: A laser catheter (10) for angioplasty is disclosed which utilizes a rotatable and axially movable beveled optical fiber, (30) which is off-axis to the axis of the catheter, to fire a laser beam (52) at an angle, (42) allowing extremely precise aiming of the laser energy at any point within the cross-section of a vessel in which the catheter is located.

Abstract translation: 公开了一种用于血管成形术的激光导管（10），其利用可旋转且可轴向移动的倾斜光纤（30），该光纤与导管的轴线偏离轴线，以一定角度发射激光束（52） ）允许在导管所在的容器的横截面内的任何点处非常精确地瞄准激光能量。

公开(公告)号：WO2015026086A2

公开(公告)日：2015-02-26

申请号：PCT/KR2014007375

申请日：2014-08-08

Applicant: HYUNJU IN TECH CO LTD

Inventor： DANCHINYU ALEXEY ,  SONG GYEONG AE

IPC: A61B17/94

CPC classification number: A61B1/00108 ,  A61B1/00066 ,  A61B1/00105 ,  A61B1/00142 ,  A61B1/00167 ,  A61B1/00186 ,  A61B1/002 ,  A61B1/042 ,  A61B1/045 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/0669 ,  A61B1/0684 ,  A61B1/07 ,  A61B18/24 ,  A61B2018/00327 ,  A61B2018/00541 ,  A61B2018/00577 ,  A61B2018/00589 ,  A61B2018/00922 ,  A61B2018/00982 ,  A61B2018/2005 ,  A61B2018/202 ,  A61B2018/20359 ,  A61B2018/2211 ,  A61B2018/2261 ,  A61B2018/2266 ,  A61B2018/2277 ,  A61B2018/2283 ,  A61F9/00821 ,  A61F2009/00868

Abstract: The present invention relates to a portable endoscope system and, more specifically, to an endoscope system having a handle and a probe detachably provided at the handle, comprising: a lighting unit using an LED as a light source such that a light irradiates towards a front side thereof; an imaging unit for forming an image of the forward light irradiated by the lighting unit so as to display the image on an external imaging apparatus; and a laser unit for carrying out treatment on an affected part displayed on the imaging unit, wherein the lighting unit, the imaging unit, and the laser unit are provided to be integrated with the handle. According to the present invention, since there is no need for a separate external imaging apparatus except for a monitor or the like, the endoscope system can be used regardless of the location and is easy to carry. Furthermore, the endoscope system is manufactured in a compact shape and size, thereby providing a functional effect for facilitating the operation thereof.

Abstract translation: 便携式内窥镜系统技术领域本发明涉及一种便携式内窥镜系统，更具体地说，涉及一种具有手柄和可拆卸地设置在手柄上的探头的内窥镜系统，包括：使用LED作为光源的照明单元， 侧面; 成像单元，用于形成由照明单元照射的前向光的图像，以在外部成像设备上显示图像; 以及激光单元，用于对在所述成像单元上显示的患部进行治疗，其中所述照明单元，所述成像单元和所述激光单元被设置为与所述手柄成一体。 根据本发明，由于除了监视器等之外不需要单独的外部成像设备，所以可以使用内窥镜系统，而不管位置如何，并且易于携带。 此外，内窥镜系统以紧凑的形状和尺寸制造，从而提供便于其操作的功能效果。

公开(公告)号：WO2011032165A3

公开(公告)日：2011-09-15

申请号：PCT/US2010048807

申请日：2010-09-14

Applicant: SLOAN KETTERING INST CANCER ,  TOLEDO-CROW RICARDO ,  PATEL SNEHAL ,  RAJADHYAKSHA MILIND

Inventor： TOLEDO-CROW RICARDO ,  PATEL SNEHAL ,  RAJADHYAKSHA MILIND

IPC: A61B18/20 ,  A61B17/32 ,  A61B18/22 ,  G06F19/00

CPC classification number: A61B18/24 ,  A61B2018/00577 ,  A61B2018/00601 ,  A61B2018/00982 ,  A61B2018/2035 ,  A61B2018/2085 ,  A61B2018/2205 ,  A61B2018/2266 ,  A61B2018/2277 ,  A61B2018/2283 ,  A61B2018/2294

Abstract: Provided and described herein are exemplary embodiments of apparatus, system, computer-accessible medium, procedure and method according to the present disclosure which can be used for providing laser steering and focusing for, e.g., incision, excision and/or ablation of tissue in minimally-invasive surgery. For example, an exemplary apparatus is provided that can include at least one optical element which can be configured to refract and/or diffract light provided in a structure which can be configured to be inserted into a body, where at least one of the optical element(s) is structured to receive the light at a first angle and generate a refracted and/or diffracted light at a second angle which can be different from the first angle relative to an optical axis. An exemplary actuating arrangement, which can be configured to control the optical element(s), can be provided and situated at least partially within the at least one structure.

Abstract translation: 本文提供和描述的是根据本公开的装置，系统，计算机可访问介质，程序和方法的示例性实施例，其可以用于提供激光转向和聚焦，以在最小程度上例如切割，切除和/或消融组织 - 侵入性手术。 例如，提供了可以包括至少一个光学元件的示例性装置，该至少一个光学元件可被配置为折射和/或衍射设置在可被配置为插入到主体中的结构中的光，其中至少一个光学元件 （s）被构造成以第一角度接收光，并以相对于光轴可以不同于第一角度的第二角度产生折射和/或衍射光。 可以提供可配置成控制光学元件的示例性致动装置，并且至少部分地位于至少一个结构内。

公开(公告)号：WO2011071776A1

公开(公告)日：2011-06-16

申请号：PCT/US2010/058942

申请日：2010-12-03

Applicant: ALCON RESEARCH, LTD. ,  SMITH, Ronald T.

Inventor： SMITH, Ronald T.

IPC: A61B18/18

CPC classification number: A61B1/0011 ,  A61B18/22 ,  A61B90/30 ,  A61B2017/00526 ,  A61B2018/00714 ,  A61B2018/2261 ,  A61B2018/2277 ,  A61B2090/306 ,  A61F9/008 ,  A61F9/00821 ,  A61F9/00823 ,  A61F2009/00863 ,  Y10T29/49885

Abstract: An optical surgical probe includes a handpiece, a light guide within the handpiece, and a multi-spot generator at a distal end of the handpiece. The handpiece is configured to optically couple to a light source. The light guide is configured to carry a light beam from the light source to a distal end of the handpiece. The multi-spot generator includes a faceted optical element with a faceted end surface spaced from a distal end of the light guide. The faceted end surface includes at least one facet oblique to a path of the light beam.

Abstract translation: 光学手术探针包括手持件，手持件内的光导件和位于手持件末端的多点发生器。 手机被配置为光学耦合到光源。 光导被配置为将来自光源的光束传送到手持件的远端。 多点发生器包括具有与光导的远端间隔开的刻面端面的刻面光学元件。 多面端面包括至少一个倾斜于光束路径的小平面。

公开(公告)号：WO2009142839A1

公开(公告)日：2009-11-26

申请号：PCT/US2009/040491

申请日：2009-04-14

Applicant: BOSTON SCIENTIFIC SCIMED, INC. ,  HANLEY, Brian, M. ,  HIXON, Jessica ,  OSKIN, Christopher, L. ,  SINOFSKY, Edward

Inventor： HANLEY, Brian, M. ,  HIXON, Jessica ,  OSKIN, Christopher, L. ,  SINOFSKY, Edward

IPC: A61B18/22 ,  G02B6/02 ,  G02B6/26

CPC classification number: A61B18/24 ,  A61B2018/2205 ,  A61B2018/2244 ,  A61B2018/2277 ,  G02B6/262 ,  Y10T29/49817

Abstract: A method and an apparatus according to an embodiment of the invention includes a distal end portion of an optical fiber core having a multilayer dielectric coating. For sidefiring optical fibers, the coating can be disposed on an angled surface at the core distal end to produce total internal reflection of laser energy at the angled surface. The coating can also be disposed on an outer surface of the distal end portion of the core. The coating and the angled surface can be collectively configured to redirect laser energy in a lateral or side-fired direction. For end-firing optical fibers, the coating can be disposed on an outer surface of the distal end portion of the core. The coating and a perpendicular surface at the core distal end can be collectively configured to direct laser energy in a direction substantially parallel to the distal end portion of the optical fiber.

Abstract translation: 根据本发明的实施例的方法和装置包括具有多层介电涂层的光纤芯的远端部分。 对于侧面激光光纤，涂层可以设置在芯远端处的倾斜表面上，以在倾斜表面处产生激光能量的全内反射。 涂层也可以设置在芯的远端部分的外表面上。 涂层和成角度的表面可以被共同配置成在侧向或侧向燃烧的方向上重定向激光能量。 对于端射光纤，涂层可以设置在芯的远端部分的外表面上。 在芯部远端处的涂层和垂直表面可以被共同构造成在基本上平行于光纤的远端部分的方向上引导激光能量。

公开(公告)号：WO02042719A2

公开(公告)日：2002-05-30

申请号：PCT/US2001/044008

申请日：2001-11-21

IPC: G02B6/42 ,  A61B18/12 ,  A61B18/20 ,  A61B18/22 ,  A61N5/06 ,  B23K26/08 ,  H01S3/00 ,  G01D

CPC classification number: A61B18/203 ,  A61B2018/00452 ,  A61B2018/2277

Abstract: The invention features systems and tools for controlling the optical penetration depth (OPD) of laser energy, e.g., when delivering laser energy to target tissue in a patient. The systems and tools control the OPD by controlling the incident angle at which the laser energy (364) is delivered to the target area of the patient. Embodiments of the invention include an optical coupler (368) that permits a user to vary the incident angle and thereby selectably control the OPD of incident laser energy (364). Fabricating the optical coupler (368) to have a refractive index greater than that of the target tissue can enhance the range of selectable OPDs. The laser energy (364), which is delivered to the desired depth, can cause alteration of the target tissue by, e.g., heating, ablation, and/or photochemical reaction.

Abstract translation: 本发明的特征在于用于控制激光能量的光学穿透深度（OPD）的系统和工具，例如当向患者中的靶组织递送激光能量时。 系统和工具通过控制将激光能量（364）输送到患者的目标区域的入射角来控制OPD。 本发明的实施例包括允许用户改变入射角并从而可选地控制入射激光能量的OPD（364）的光耦合器（368）。 制造光学耦合器（368）以具有比目标组织的折射率更大的折射率可以增强可选OPD的范围。 被输送到所需深度的激光能量（364）可以通过例如加热，消融和/或光化学反应来引起目标组织的改变。

公开(公告)号：WO0195821A3

公开(公告)日：2002-05-16

申请号：PCT/CA0100905

申请日：2001-06-15

Applicant: AUTOLITT INC ,  TORCHIA MARK G ,  TYC RICHARD ,  MCTAGGART KEN J ,  PACAK JOHN S

Inventor： TORCHIA MARK G ,  TYC RICHARD ,  MCTAGGART KEN J ,  PACAK JOHN S

IPC: G01R33/28 ,  A61B5/055 ,  A61B18/00 ,  A61B18/20 ,  A61B18/22 ,  A61B18/24 ,  A61B19/00 ,  A61N5/06

CPC classification number: A61B18/24 ,  A61B5/055 ,  A61B18/20 ,  A61B90/36 ,  A61B2018/00023 ,  A61B2018/00196 ,  A61B2018/00636 ,  A61B2018/1861 ,  A61B2018/2005 ,  A61B2018/2277 ,  A61B2090/374

Abstract: An MRI guided surgical apparatus includes a heat source formed by a laser (21) and an optical (20) fiber carrying the heat energy into a part to be coagulated by hyperthermia with an end reflector to direct the energy in a beam to one side of the fiber end. A reinforcing sleeve (38) for the fiber is mounted in a shielded, Piezo-electric motor (22) which causes movement of the fiber longitudinally and angularly within a rigid elongate cannula. A magnetic resonance imaging system is arranged to generate a series of output signals over a period of time representative of temperature in the part as the temperature of the part changes during that time. The heat source is controlled in heat energy applied and location and orientation of the beam to stop heating when the temperature at the boundary of a tumor reaches the required hyperthermic temperature. Cooling of the tip portion of the probe can be effected by encasing the fiber in a tubing material defining a duct for the fiber and supply and return parallel ducts for cooling fluid, the tubing being encased in a titanium stiffening sleeve which is driven in the longitudinal and rotational directions to move the fiber tip.

Abstract translation: MRI引导手术装置包括由激光器（21）和光学（20）光纤形成的热源，光纤（20）将热能携带到通过热反射器凝结的部分中，以将射束中的能量引导到光束的一侧 纤维端。 用于纤维的加强套筒（38）​​安装在屏蔽的压电电动机（22）中，导致纤维在刚性细长插管内纵向和角度地移动。 磁共振成像系统被布置成随着部件温度在该时间段内的温度变化而在一段时间内产生一系列输出信号。 当肿瘤边界处的温度达到所需的高温温度时，热源受到热能的控制，光束的位置和取向停止加热。 探针的尖端部分的冷却可以通过将纤维包封在限定用于纤维的管道的管材料中并且供给并返回用于冷却流体的平行管道来实现，该管道被包裹在钛加强套筒中，该加强套管在纵向 和旋转方向以移动纤维尖端。

公开(公告)号：WO2019140451A1

公开(公告)日：2019-07-18

申请号：PCT/US2019/013688

申请日：2019-01-15

Applicant: CARDIOFOCUS, INC.

Inventor： MELSKY, Gerald ,  ESTABROOK, Brian ,  BAXTER, Lincoln ,  BABKO-MALYI, Sergei ,  GREEN, Ronald ,  DICESARE, Paul

IPC: A61B18/02 ,  A61M25/04

CPC classification number: A61B18/18 ,  A61B17/22012 ,  A61B17/320068 ,  A61B18/1815 ,  A61B18/24 ,  A61B34/10 ,  A61B90/30 ,  A61B90/361 ,  A61B90/37 ,  A61B2017/00017 ,  A61B2017/00128 ,  A61B2017/00247 ,  A61B2017/22069 ,  A61B2017/320069 ,  A61B2017/320098 ,  A61B2018/00196 ,  A61B2018/00208 ,  A61B2018/00232 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/0066 ,  A61B2018/00684 ,  A61B2018/00702 ,  A61B2018/00761 ,  A61B2018/00785 ,  A61B2018/00839 ,  A61B2018/00898 ,  A61B2018/00904 ,  A61B2018/00982 ,  A61B2018/1823 ,  A61B2018/1861 ,  A61B2018/2025 ,  A61B2018/20357 ,  A61B2018/20361 ,  A61B2018/20553 ,  A61B2018/2272 ,  A61B2018/2277 ,  A61B2034/107 ,  A61B2090/306 ,  A61B2090/3614

Abstract: An ablation instrument (e.g., an ablation balloon catheter system) includes an elongate catheter having a housing with a window formed therein. An energy emitter is coupled to the elongate catheter and is configured to deliver ablative energy. A controller is received within the window and is coupled to the energy emitter such that axial movement of the controller within the window is translated to axial movement of the energy emitter and rotation of the controller within the window is translated into rotation of the energy emitter. The instrument includes a motor that is at least partially disposed within the housing of the catheter; a first gear that is operatively connected to and driven by the motor; and a second gear that is coupled to the energy emitter and is driven by the first gear to cause rotation of the energy emitter, while allowing the energy emitter to move axially.