公开(公告)号：WO2016065096A8

公开(公告)日：2016-08-11

申请号：PCT/US2015056814

申请日：2015-10-22

Applicant: INTERNAT PARTNERSHIP FOR MICROBICIDES INC

Inventor： BLANDA WENDY ,  HOLT JONATHON DARYLL ,  BRIMER ANDREW NATHAN ,  MALCOLM KARL ,  MCCOY CLARE ,  MURPHY DIARMAID ,  BOYD PETER JOHN JAMES

IPC: A61F6/14 ,  A61K47/02 ,  A61K47/04

CPC classification number: A61F6/14 ,  A61F6/06 ,  A61K9/0036 ,  A61K31/505 ,  A61K31/567 ,  A61K2300/00

Abstract: The present invention provides intravaginal drug delivery devices, such as intravaginal rings, comprising active pharmaceutical ingredients (APIs) having terminal alkene, alkyne or carbonyl functionalities. The devices of the invention exhibit increased recovery of the active pharmaceutical ingredient from platinum-catalyzed silicone polymers due to the optimization of drug particle size and cure conditions. The present invention also provides methods of preventing unintended pregnancy in a female human, methods of preventing unintended pregnancy in a female human and HIV infection in a female human, and methods of preparing intravaginal drug delivery devices.

Abstract translation: 本发明提供了包含具有末端烯烃，炔烃或羰基官能团的活性药物成分（API）的阴道内药物递送装置，例如阴道内环。 由于药物颗粒大小和固化条件的优化，本发明的装置表现出由铂催化的硅氧烷聚合物提高的活性药物成分的回收率。 本发明还提供了预防女性中意外怀孕的方法，防止女性中的意外怀孕和女性中的HIV感染的方法，以及制备阴道内药物递送装置的方法。

公开(公告)号：WO2016065096A1

公开(公告)日：2016-04-28

申请号：PCT/US2015/056814

申请日：2015-10-22

Applicant: INTERNATIONAL PARTNERSHIP FOR MICROBICIDES, INC.

Inventor： BLANDA, Wendy ,  HOLT, Jonathon, Daryll ,  BRIMER, Andrew, Nathan ,  MALCOLM, Karl ,  MCCOY, Clare ,  MURPHY, Diarmaid ,  BOYD, Peter, John James

IPC: A61F6/14 ,  A61K47/02 ,  A61K47/04

CPC classification number: A61F6/14 ,  A61F6/06 ,  A61K9/0036 ,  A61K31/505 ,  A61K31/567 ,  A61K2300/00

Abstract: The present invention provides intravaginal drug delivery devices, such as intravaginal rings, comprising active pharmaceutical ingredients (APIs) having terminal alkene, alkyne or carbonyl functionalities. The devices of the invention exhibit increased recovery of the active pharmaceutical ingredient from platinum-catalyzed silicone polymers due to the optimization of drug particle size and cure conditions. The present invention also provides methods of preventing unintended pregnancy in a female human, methods of preventing unintended pregnancy in a female human and HIV infection in a female human, and methods of preparing intravaginal drug delivery devices.

Abstract translation: 本发明提供阴道内药物递送装置，例如阴道内环，其包含具有末端烯烃，炔烃或羰基官能团的活性药物成分（API）。 由于药物粒径和固化条件的优化，本发明的装置表现出活性药物成分从铂催化的硅氧烷聚合物的增加的恢复。 本发明还提供了在女性人体中预防意外怀孕的方法，在女性人体中预防女性人类意外怀孕和HIV感染的方法以及制备阴道内药物递送装置的方法。

公开(公告)号：WO2013042134A1

公开(公告)日：2013-03-28

申请号：PCT/IN2011/000853

申请日：2011-12-14

Applicant: PREGNA INTERNATIONAL LIMITED ,  TICKET DESIGN PVT LTD ,  PANDIT, Nishma

Inventor： PANDIT, Nishma

IPC: A61F6/18 ,  A61F6/14

CPC classification number: A61F6/144 ,  A61F6/00 ,  A61F6/06 ,  A61F6/14 ,  A61F6/18

Abstract: The present invention provides a loading, inserting and releasing means (a loading means) for T-shaped intrauterine device (IUD) into uterus. The loading means comprises a shaft member having a loader, an inserter tube, an IUD and a plunger. The loading means includes a platform configured at a proximal end of the loader for holding the IUD in an open position, and an elongated member extending from the platform. The elongated member includes a slot running therethrough aligned to the opening of the loader. Further, the loading means includes a plunger within an inserter tube capable of running through a slot provided with markings thereon. The inserter tube is provided with a knob for pushing the inserter tube along with plunger in forward and backward direction for inserting and releasing the T-shaped IUD into the uterus.

Abstract translation: 本发明提供了一种用于T型子宫内装置（IUD）进入子宫的装载，插入和释放装置（装载装置）。 装载装置包括具有装载器，插入管，IUD和柱塞的轴构件。 装载装置包括一个平台，该平台构造在装载机的近端处，用于将IUD保持在打开位置，以及从平台延伸的细长构件。 细长构件包括穿过与其对齐的装载器的开口的狭槽。 此外，装载装置包括插入管内的柱塞，其能够穿过其上具有标记的槽。 插入管设置有用于将插入管与柱塞一起向前和向后推动的旋钮，用于将T形IUD插入和释放到子宫中。

公开(公告)号：WO2012158970A1

公开(公告)日：2012-11-22

申请号：PCT/US2012/038440

申请日：2012-05-17

Applicant: FONG, Edward, C. ,  LA MARGO, Claire, E.

Inventor： FONG, Edward, C. ,  LA MARGO, Claire, E.

IPC: A61F6/06

CPC classification number: A61F6/06 ,  A61F2006/041

Abstract: The present disclosure advantageously provides a female contraceptive device, methods of using the contraceptive device, and methods of making the contraceptive device.

Abstract translation: 本公开有利地提供了雌性避孕装置，使用避孕装置的方法以及制造避孕装置的方法。

公开(公告)号：WO2011034754A2

公开(公告)日：2011-03-24

申请号：PCT/US2010/048024

申请日：2010-09-07

Applicant: CONCEPTUS, INC. ,  CRUZADA, Julian ,  SWANN, Betsy

Inventor： CRUZADA, Julian ,  SWANN, Betsy

IPC: A61F6/18 ,  A61F6/22

CPC classification number: A61F6/06 ,  A61F6/18 ,  A61F6/225

Abstract: Embodiments of the present invention provide systems and methods for delivering a contraceptive device to an ovarian pathway. The contraceptive device is within an enclosure in a first position. In a second position, the contraceptive device is positioned at the ovarian pathway, by actuating a first actuator. The contraceptive device is then expanded and released from the delivery system by actuating a second actuator.

Abstract translation: 本发明的实施方案提供了将避孕装置递送至卵巢途径的系统和方法。 避孕装置位于第一位置的外壳内。 在第二位置，避孕装置通过致动第一致动器而定位在卵巢通路处。 然后通过致动第二致动器将避孕装置扩展并从输送系统释放。

公开(公告)号：WO2009140686A3

公开(公告)日：2010-07-01

申请号：PCT/US2009044381

申请日：2009-05-18

Applicant: CONCEPTUS INC ,  JIMENEZ JOSE W ,  MUJWID JAMES R ,  TREMULIS WILLIAM S ,  FRIGSTAD JOHN R ,  JAGGER KARL A ,  ARNAL KEVIN R ,  CALLISTER JEFFREY P

Inventor： JIMENEZ JOSE W ,  MUJWID JAMES R ,  TREMULIS WILLIAM S ,  FRIGSTAD JOHN R ,  JAGGER KARL A ,  ARNAL KEVIN R ,  CALLISTER JEFFREY P

IPC: A61F6/22

CPC classification number: A61F6/005 ,  A61F6/06 ,  A61F6/22 ,  A61F6/225

Abstract: A system and method of occluding a reproductive body lumen (34) to prevent the passage of reproductive cells through body lumen is disclosed. The system can include a catheter delivery system (10) having a handle device (18), a catheter (10) operatively coupled with the handle device (20), and an occluding device adapted for deployment within the body lumen. The handle device can include a damper device adapted to reduce the vibration on the handle device from deployment of the occluding device from the catheter. Further, the handle device can include an indexing member operatively coupled with the catheter to provide indexing of the catheter.

Abstract translation: 公开了一种闭塞生殖体腔（34）以防止生殖细胞通过体腔通过的系统和方法。 该系统可以包括具有手柄装置（18）的导管输送系统（10），与手柄装置（20）可操作地连接的导管（10）和适于部署在体腔内的闭塞装置。 手柄装置可以包括阻尼器装置，其适于减少手柄装置上的振动，使得阻塞装置从导管部署。 此外，手柄装置可以包括与导管可操作地连接以提供导管的分度的分度构件。

公开(公告)号：WO2006017341A3

公开(公告)日：2006-03-16

申请号：PCT/US2005024872

申请日：2005-07-12

Applicant: UMD INC

Inventor： WILSON MICHELLE ,  DESAI KISHORKUMAR J ,  PAULETTI GIOVANNI M ,  ANTOON MITCHELL K JR ,  CLENDENING CHRIS E

IPC: A61F6/06 ,  A61F6/14 ,  A61F13/02 ,  A61K9/00 ,  A61K9/02 ,  A61K9/12 ,  A61K9/20 ,  A61K9/48 ,  A61K9/70

CPC classification number: A61F6/06 ,  A61F6/08 ,  A61F13/2051 ,  A61K9/0034 ,  A61K9/0036 ,  A61K9/02 ,  A61K9/122 ,  A61K9/7007

Abstract: A vaginal device for delivering therapeutical and/or health-promoting agents. The vaginal device partly or completely coated by, covered by or combined with a coating or covering comprising a film, foam, strip, cap, cup or particles. The coating of the device comprises -a mucoadhesive composition comprising a therapeutical and/or health-promoting agent.

Abstract translation: 用于递送治疗和/或健康促进剂的阴道装置。 阴道装置部分地或完全被涂层，覆盖或与包括膜，泡沫，条带，帽，杯或颗粒的涂层或覆盖物组合。 该装置的涂层包括 - 包含治疗和/或健康促进剂的粘膜粘附组合物。

公开(公告)号：WO2001013834A1

公开(公告)日：2001-03-01

申请号：PCT/US2000023038

申请日：2000-08-22

Applicant: CONCEPTUS, INC.

Inventor： CONCEPTUS, INC. ,  LOWE, Christian ,  GURSKIS, Don ,  KHERA, Ashish ,  BARNHART, Monica ,  BACICH, Steven ,  SWANN, Betsy ,  SILVA-TORRES, Roberto

IPC: A61F6/06

CPC classification number: A61F6/06 ,  A61B1/307 ,  A61B2017/2923 ,  A61B2017/2929 ,  A61B2017/2943 ,  A61F6/18 ,  A61F6/225

Abstract: Contraceptive methods, systems and devices generally improve the ease, speed, and reliability with which a contraceptive device (12) can be deployed transcervically into an ostium of a fallopian tube. The contraceptive device (12) may remain in a small profile configuration while a sheath (114) is withdrawn proximally and is thereafter expanded to a large profile configuration engaging the surrounding tissues, by manipulating one or more actuators of a proximal handle (30) with a single hand. This leaves the other hand free to manipulate a hysteroscope, minimizing the number of health care professional required to deploy the contraceptive device.

Abstract translation: 避孕方法，系统和装置通常可以改善缓解，速度和可靠性，避孕装置（12）能够经腹腔插入输卵管的口中。 避孕装置（12）可以保持在小的轮廓构造中，同时护套（114）向近侧拉出并且随后通过操纵近侧手柄（30）的一个或多个致动器而扩展成与周围组织接合的大轮廓构型， 单手。 这另一方面可以自由地操纵宫腔镜，最大限度地减少部署避孕装置所需的医疗保健专业人员的数量。

公开(公告)号：WO1988009647A1

公开(公告)日：1988-12-15

申请号：PCT/AT1988000042

申请日：1988-06-03

Applicant: CARINTHIA TEXTILINDUSTRIEGESELLSCHAFT M.B.H. ,  LENGERKE, Axel

Inventor： CARINTHIA TEXTILINDUSTRIEGESELLSCHAFT M.B.H.

IPC: A61F05/00

CPC classification number: A61F6/06

Abstract: In a process for rendering women reversibly infertile by quasi-sterilization, each ovary (3) is screened from the fringed (5) funnel-shaped end (4) of the Fallopian tube by implantation of a filter (6) of pore size between 0,2 and 110 mum which prevents a ripe egg from entering the Fallopian tube (2) after its release and ejection from the follicle. Various executions of the filter (6) are described and illustrated.

公开(公告)号：WO2017060299A1

公开(公告)日：2017-04-13

申请号：PCT/EP2016/073788

申请日：2016-10-05

Applicant: LIGALLI B.V.

Inventor： DE LAAT, Wilhelmus Nicolaas Gerardus Maria

IPC: A61F6/06 ,  A61K9/00 ,  A61F6/14 ,  A61M31/00

CPC classification number: A61F6/14 ,  A61F6/06 ,  A61K9/0036 ,  A61M31/002 ,  A61M2210/1475

Abstract: The present invention is related to a vaginal drug delivery device and to a vaginal diagnostic device that comprises a first and second rigid member, wherein the first and/or second rigid member comprises a reservoir holding a medicament to be delivered, an opening, and a pump for pumping said medicament out of said opening, and/or wherein the first rigid member and/or second rigid member comprises a diagnostic device for performing an intravaginal diagnosis or measurement therefor. The device further comprises a first flexible member and flexible part, wherein at least one of the first flexible member and the flexible part is at least partially elastic having an elasticity such that the device can be squeezed from an extended shape to a collapsed shape. The device is pre-biased to assume the extended shape when little to no external force is being applied thereto. Furthermore, the device assumes a shape substantially corresponding to the extended shape when the device is inserted with the squeezed rigid member first, so that these naturally unfold in the formix posterior vaginae.

Abstract translation: 本发明涉及阴道药物递送装置和包括第一和第二刚性构件的阴道诊断装置，其中第一和/或第二刚性构件包括容纳待输送药物的储存器，开口和 用于从所述开口泵出所述药物的泵，和/或其中所述第一刚性构件和/或第二刚性构件包括用于进行阴道内诊断或测量的诊断装置。 该装置还包括第一柔性构件和柔性部件，其中第一柔性构件和柔性部件中的至少一个至少部分弹性具有弹性，使得该装置可以从延伸形状挤压成塌缩形状。 当很少甚至没有施加外部力时，该装置被预偏压以呈现延伸的形状。 此外，当装置首先用挤压的刚性构件插入装置时，该装置呈现大致对应于延伸形状的形状，使得这些形状自然地在后面阴道中展开。