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1.发明申请COATED VAGINAL DEVICES FOR VAGINAL DELIVERY OF THERAPEUTICALLY EFFECTIVE AND/ OR HEALTH-PROMOTING AGENTS 审中-公开用于阴道输送治疗有效和/或促进健康的药物的涂敷的阴道装置
公开(公告)号：WO2006017341A2
公开(公告)日：2006-02-16
申请号：PCT/US2005/024872
申请日：2005-07-12
Applicant: UMD, INC.
Inventor： WILSON, Michelle , DESAI, Kishorkumar, J. , PAULETTI, Giovanni, M. , ANTOON, Mitchell, K., Jr. , CLENDENING, Chris, E.
IPC: A61K9/70
CPC classification number: A61F6/06 , A61F6/08 , A61F13/2051 , A61K9/0034 , A61K9/0036 , A61K9/02 , A61K9/122 , A61K9/7007
Abstract: A vaginal device for delivering therapeutical and/or health-promoting agents. The vaginal device partly or completely coated by, covered by or combined with a coating or covering comprising a film, foam, strip, cap, cup or particles. The coating of the device comprises -a mucoadhesive composition comprising a therapeutical and/or health-promoting agent.
Abstract translation: 一种用于输送治疗和/或健康促进剂的阴道装置。 阴道装置部分地或完全地由包括膜，泡沫，条，帽，杯或颗粒的涂层或覆盖物覆盖或与其组合。 该装置的涂层包含 - 包含治疗和/或健康促进剂的粘膜粘附组合物。
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公开(公告)号：WO2004067063A3
公开(公告)日：2004-08-12
申请号：PCT/US2004/000902
申请日：2004-01-14
Applicant: UMD, INC.
Inventor： PAULETTI, Giovanni, M. , CLENDENING, Chris, E.
IPC: A61F13/00
Abstract: Devices, methods, and improved formulation for transmucosal vaginal delivery of bisphosphonates. A targeted site delivery of bisphosphonates to the systemic circulation using a vaginal device comprising an improved bisphosphonate formulation for transmucosal delivery. A method for treatment of osteoporosis and related bone and skeleton diseases, for prevention of bone breakdown and loss of bone mass and strength by intravaginal administration of bisphosphonates to the vagina and transmucosal delivery of bisphosphonates to the general circulation.
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3.发明申请A METHOD FOR AUGMENTATION OF INTRAEPITHELIAL AND SYSTEMIC EXPOSURE OF THERAPEUTIC AGENTS HAVING SUBSTRATE ACTIVITY FOR CYTOCHROME P450 ENZYMES AND MEMBRANE EFFLUX SYSTEMS FOLLOWING VAGINAL AND ORAL 审中-公开用于补充具有用于细胞色素P450酶的底物活性的治疗剂的系统性和系统性接触的方法和随着口腔和口腔的膜结合体系
公开(公告)号：WO2007035515A2
公开(公告)日：2007-03-29
申请号：PCT/US2006/036087
申请日：2006-09-15
Applicant: UMD, INC.
Inventor： PAULETTI, Giovanni, M.
IPC: A61K36/906 , A61K36/28 , A61K36/752 , A61K36/67 , A61K36/84 , A61K36/00 , A61K9/14
CPC classification number: A61K36/28 , A61K9/0034 , A61K9/006 , A61K9/02 , A61K9/122 , A61K9/7007 , A61K36/185 , A61K36/324 , A61K36/54 , A61K36/67 , A61K36/71 , A61K36/752 , A61K36/77 , A61K36/82 , A61K36/84 , A61K36/8962 , A61K36/906 , A61K36/9068
Abstract: A vaginal or buccal delivery of therapeutic agents having a substrate affinity for metabolic cytochrome P-450 enzymes and membrane efflux transporter systems. A method for augmentation of systemic exposure to the therapeutic agents having a substrate affinity for cytochrome P-450 enzymes and membrane efflux transporter systems, by delivering said agents to the systemic circulation through vaginal or buccal mucosa.
Abstract translation: 对代谢细胞色素P-450酶和膜外排运输系统具有底物亲和力的治疗剂的阴道或口腔递送。 通过将所述药物通过阴道或颊粘膜递送至全身循环，增加对细胞色素P-450酶和膜外排转运体系具有底物亲和力的治疗剂的全身暴露的方法。
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4.发明申请THERAPEUTIC COMPOSITIONS FOR DRUG DELIVERY TO AND THROUGH COVERING EPITHELIA 审中-公开用于药物递送和通过覆盖上皮的治疗组合物
公开(公告)号：WO2004041118A2
公开(公告)日：2004-05-21
申请号：PCT/US2003/034643
申请日：2003-10-31
Applicant: UMD, INC.
Inventor： PAULETTI, Giovanni, M. , DESAI, Kishorkumar, J. , ROWETON, Susan, L. , HARRISON, Donald, C. , SANDERS, Lyndia, M.
IPC: A61F
CPC classification number: A61K45/06 , A61K9/0034 , A61K9/0043 , A61K9/006 , A61K9/02 , A61K9/12 , A61K9/7007 , A61K31/192 , A61K31/196 , A61K31/277 , A61K31/337 , A61K31/405 , A61K31/407 , A61K31/5415 , A61K31/616 , A61K31/663 , A61K38/00 , A61L15/425 , A61L15/44 , A61L26/0066 , A61L26/0085 , A61L2300/41
Abstract: Polymer foams and films for delivery of therapeutic agents to and through nasal, oral or vaginal mucosa and cornified or non-cornified epithelium of labia and scrotum. Polymer foams or absorbable or non-absorbable films containing a therapeutic agent incorporated therein wherein said agent is released from said foams or films upon placement of said foam or film on the surface epithelium of nasal, oral, or vaginal labia or scrotum. The foam or the film has a controllable rate of gelling, swelling and degradation and is preformed into a device or is applied as a coating to a surface of a more complex drug delivery system.
Abstract translation: 用于将治疗剂递送到鼻腔，口腔或阴道粘膜和阴唇和阴囊角质或非角化的上皮的聚合物泡沫和膜。 含有其中掺入治疗剂的聚合物泡沫或可吸收或不可吸收的膜，其中所述试剂在将所述泡沫或薄膜置于鼻腔，口腔或阴道阴唇或阴囊的表面上皮上时从所述泡沫或薄膜中释放。 泡沫或膜具有可控的胶凝，溶胀和降解速率，并且预成型为装置，或作为涂层施用于更复杂的药物递送系统的表面。
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5.发明申请COATED VAGINAL DEVICE FOR DELIVERY OF ANTI-MIGRAINE AND ANTI-NAUSEA DRUGS AND A METHOD FOR TREATMENT OF MIGRAINE AND NAUSEA 审中-公开用于输送抗血清和抗病毒药物的涂覆的血管装置和用于治疗小鼠和鼻血管的方法
公开(公告)号：WO2006017238A1
公开(公告)日：2006-02-16
申请号：PCT/US2005/024581
申请日：2005-07-11
Applicant: UMD, INC.
Inventor： PAULETTI, Giovanni, M. , WILSON, Michelle , SODERSTROM, Richard , DESAI, Kishorkumar, J. , RITSCHEL, Wolfgang, A.
IPC: A61F6/06
CPC classification number: A61F6/06 , A61F6/08 , A61F13/2051 , A61K9/0034 , A61K9/0036 , A61K9/02 , A61K9/122 , A61K9/7007
Abstract: A vaginal device for delivery of an anti-migraine or anti-nausea drug to the uterus and/or to the general circulation through vaginal mucosa. The device is at least partially coated with one or several layers of fluid impermeable material forming a cap, film, foam, foil or strip incorporated with mucoadhesive composition comprising the anti-migraine or anti-nausea drug.
Abstract translation: 用于通过阴道粘膜递送抗偏头痛或抗恶心药物到子宫和/或一般循环的阴道装置。 该装置至少部分地涂覆有形成具有包含抗偏头痛或抗恶心药物的粘膜粘附组合物的帽，膜，泡沫，箔或条的一层或几层流体不可渗透材料。
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Patent Agency Ranking6.发明申请THERAPEUTIC COMPOSITIONS FOR DRUG DELIVERY TO AND THROUGH COVERING EPITHELIA 审中-公开用于药物递送和通过覆盖上皮的治疗组合物
公开(公告)号：WO2004041118A8
公开(公告)日：2005-06-09
申请号：PCT/US0334643
申请日：2003-10-31
Applicant: UMD INC
Inventor： PAULETTI GIOVANNI M , DESAI KISHORKUMAR J , ROWETON SUSAN L , HARRISON DONALD C , SANDERS LYNDA M
IPC: A61K9/00 , A61K9/02 , A61K9/12 , A61K9/70 , A61K31/192 , A61K31/196 , A61K31/277 , A61K31/337 , A61K31/405 , A61K31/407 , A61K31/5415 , A61K31/616 , A61K31/663 , A61K38/11 , A61K38/20 , A61K38/27 , A61K38/28 , A61K45/06
CPC classification number: A61K45/06 , A61K9/0034 , A61K9/0043 , A61K9/006 , A61K9/02 , A61K9/12 , A61K9/7007 , A61K31/192 , A61K31/196 , A61K31/277 , A61K31/337 , A61K31/405 , A61K31/407 , A61K31/5415 , A61K31/616 , A61K31/663 , A61K38/00 , A61L15/425 , A61L15/44 , A61L26/0066 , A61L26/0085 , A61L2300/41
Abstract: Polymer foams and films for delivery of therapeutic agents to and through nasal, oral or vaginal mucosa and cornified or non-cornified epithelium of labia and scrotum. Polymer foams or absorbable or non-absorbable films containing a therapeutic agent incorporated therein wherein said agent is released from said foams or films upon placement of said foam or film on the surface epithelium of nasal, oral, or vaginal labia or scrotum. The foam or the film has a controllable rate of gelling, swelling and degradation and is preformed into a device or is applied as a coating to a surface of a more complex drug delivery system.
Abstract translation: 用于将治疗剂递送到鼻腔，口腔或阴道粘膜和阴唇和阴囊角质或非角化的上皮的聚合物泡沫和膜。 含有其中掺入治疗剂的聚合物泡沫或可吸收或不可吸收的膜，其中所述试剂在将所述泡沫或薄膜置于鼻腔，口腔或阴道阴唇或阴囊的表面上皮上时从所述泡沫或薄膜中释放。 泡沫或膜具有可控的胶凝，溶胀和降解速率，并且预成型为装置，或作为涂层施用于更复杂的药物递送系统的表面。
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7.发明申请
公开(公告)号：WO2003020210A3
公开(公告)日：2003-03-13
申请号：PCT/US2002/027027
申请日：2002-08-21
Applicant: UMD, INC.
Inventor： PAULETTI, Giovanni, M. , LIU, James, H. , BENET, Leslie, Z. , RITSCHEL, Wolfgang, A.
IPC: A61F6/06
Abstract: Devices, methods, and compositions for cancer therapy by administration of chemotherapeutic agents and/or inhibitors of membrane efflux systems to the vagina for topical and systemic tumor targets.
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8.发明申请VAGINAL DELIVERY OF CHEMOTHERAPEUTIC AGENTS AND INHIBITORS OF MEMBRANE EFFLUX SYSTEMS FOR CANCER THERAPY 审中-公开化疗药物的阴道输送和用于癌症治疗的膜结合系统的抑制剂
公开(公告)号：WO2003020210A2
公开(公告)日：2003-03-13
申请号：PCT/US2002/027027
申请日：2002-08-21
Applicant: UMD, INC.
Inventor： PAULETTI, Giovanni, M. , LIU, James, H. , BENET, Leslie, Z. , RITSCHEL, Wolfgang, A.
IPC: A61K
CPC classification number: A61K9/0034 , A61K9/0036
Abstract: Devices, methods, and compositions for cancer therapy by administration of chemotherapeutic agents and/or inhibitors of membrane efflux systems to the vagina for topical and systemic tumor targets.
Abstract translation: 通过将化学治疗剂和/或膜外排系统抑制剂施用于阴道用于局部和全身肿瘤靶标的癌症治疗的装置，方法和组合物。
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9.发明申请A METHOD OF INTRAEPITHELIAL AND SYSTEMIC EXPOSURE OF THERAPEUTIC AGENTS FOLLOWING VAGINAL AND ORAL CAVITY ADMINISTRATION 审中-公开在口腔和口腔清洁管理下治疗药物的内在和系统接触的方法
公开(公告)号：WO2007035515A3
公开(公告)日：2007-09-27
申请号：PCT/US2006036087
申请日：2006-09-15
Applicant: UMD INC
Inventor： PAULETTI GIOVANNI M
CPC classification number: A61K36/28 , A61K9/0034 , A61K9/006 , A61K9/02 , A61K9/122 , A61K9/7007 , A61K36/185 , A61K36/324 , A61K36/54 , A61K36/67 , A61K36/71 , A61K36/752 , A61K36/77 , A61K36/82 , A61K36/84 , A61K36/8962 , A61K36/906 , A61K36/9068
Abstract: A vaginal or buccal delivery of therapeutic agents having a substrate affinity for metabolic cytochrome P-450 enzymes and membrane efflux transporter systems. A method for augmentation of systemic exposure to the therapeutic agents having a substrate affinity for cytochrome P-450 enzymes and membrane efflux transporter systems, by delivering said agents to the systemic circulation through vaginal or buccal mucosa.
Abstract translation: 对代谢细胞色素P-450酶和膜外排运输系统具有底物亲和力的治疗剂的阴道或口腔递送。 通过将所述药物通过阴道或颊粘膜递送至全身循环，增加对细胞色素P-450酶和膜外排转运体系具有底物亲和力的治疗剂的全身暴露的方法。
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10.发明申请COATED VAGINAL DEVICES FOR VAGINAL DELIVERY OF THERAPEUTICALLY EFFECTIVE AND/ OR HEALTH-PROMOTING AGENTS 审中-公开用于神经递送治疗有效和/或健康促进剂的包装的视网膜装置
公开(公告)号：WO2006017341A3
公开(公告)日：2006-03-16
申请号：PCT/US2005024872
申请日：2005-07-12
Applicant: UMD INC
Inventor： WILSON MICHELLE , DESAI KISHORKUMAR J , PAULETTI GIOVANNI M , ANTOON MITCHELL K JR , CLENDENING CHRIS E
IPC: A61F6/06 , A61F6/14 , A61F13/02 , A61K9/00 , A61K9/02 , A61K9/12 , A61K9/20 , A61K9/48 , A61K9/70
CPC classification number: A61F6/06 , A61F6/08 , A61F13/2051 , A61K9/0034 , A61K9/0036 , A61K9/02 , A61K9/122 , A61K9/7007
Abstract: A vaginal device for delivering therapeutical and/or health-promoting agents. The vaginal device partly or completely coated by, covered by or combined with a coating or covering comprising a film, foam, strip, cap, cup or particles. The coating of the device comprises -a mucoadhesive composition comprising a therapeutical and/or health-promoting agent.
Abstract translation: 用于递送治疗和/或健康促进剂的阴道装置。 阴道装置部分地或完全被涂层，覆盖或与包括膜，泡沫，条带，帽，杯或颗粒的涂层或覆盖物组合。 该装置的涂层包括 - 包含治疗和/或健康促进剂的粘膜粘附组合物。
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