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    DRUG COATED BALLOON CATHETER ARTERIOVENOUS SHUNT
    2.
    发明申请
    DRUG COATED BALLOON CATHETER ARTERIOVENOUS SHUNT 审中-公开
    药物涂层气囊导管动静脉分流

    公开(公告)号：WO2017072545A1

    公开(公告)日：2017-05-04

    申请号：PCT/IB2015/002090

    申请日：2015-10-30

    申请人： ACOTEC SCIENTIFIC CO. LTD.

    发明人： SCHAFFNER, Silvio

    IPC分类号： A61M25/10

    CPC分类号： A61M25/104 ,  A61M25/1002 ,  A61M2025/105 ,  A61M2025/1075 ,  A61M2025/1079 ,  A61M2025/1084

    摘要： A drug coated balloon (DCB) catheter (4) comprising a connector (8), a shaft (20) extending from a proximal end (24) to a distal end (28) along an axial direction (X-X) and having a guidewire lumen (32) and an inflation lumen (36), the shaft (20) being connected to the connector (8) on said proximal end (24) and provided with an inflatable balloon (48), fluidically connected with said inflation lumen (36) in order to be selectively inflated and/or deflated. Advantageously the balloon (48) is conical and axis-symmetrical around a prevalent extension axis (S-S), wherein the balloon (48) has an increasing diameter (60), moving from a first end (52) to a second end (56), said diameter (60) being measured on a section plane perpendicular to said prevalent extension axis (S-S), wherein an external surface (64) of the balloon (48) is coated with a drug for treating restenosis.

    摘要翻译： 一种药物涂覆球囊（DCB）导管（4），其包括连接器（8），沿轴向从近端（24）延伸至远端（28）的轴（20） （20）在所述近端（24）上连接到所述连接器（8）并且设置有可膨胀气囊（48），所述可膨胀气囊（48）流体连接到所述连接器（XX）并且具有导丝腔32和膨胀腔36。 与所述膨胀管腔（36）连接以便选择性地膨胀和/或放气。 有利的是，球囊（48）围绕主流延伸轴线（SS）呈圆锥形且轴对称，其中球囊（48）具有从第一端部（52）向第二端部（56）移动的直径增大（60） ，所述直径（60）在垂直于所述主流延伸轴线（SS）的截面上测量，其中所述球囊（48）的外表面（64）涂覆有用于治疗再狭窄的药物。

    DRUG-COATED MEDICAL DEVICES
    3.
    发明申请
    DRUG-COATED MEDICAL DEVICES 审中-公开
    药物包装医疗器械

    公开(公告)号：WO2017007430A1

    公开(公告)日：2017-01-12

    申请号：PCT/SG2016/050318

    申请日：2016-07-08

    申请人： JMEDTECH PTE LTD

    发明人： LUO, Jingnan ,  LEE, Qian Yi, Michele ,  WANG, Honglei

    IPC分类号： A61L29/08 ,  A61M25/10 ,  A61L33/00 ,  A61K31/00 ,  A61K47/30

    CPC分类号： A61L29/16 ,  A61K31/337 ,  A61K31/436 ,  A61L29/085 ,  A61L2300/416 ,  A61L2300/62 ,  A61L2300/622 ,  A61L2300/624 ,  A61L2420/02 ,  A61M25/1029 ,  A61M2025/1004 ,  A61M2025/1031 ,  A61M2025/105 ,  A61M2025/1075

    摘要： Disclosed herein is a drug-coated medical device in the form of a balloon having an inner surface and an outer hydrophobic surface, an adhesion balance layer directly on the outer hydrophobic surface of the balloon, comprising a hydrophilic polymer and/or a hydrophilic compound where the hydrophilic compound has a molecular weight of less than 1,000 Daltons, and a therapeutic layer directly on the adhesion balance layer comprising a therapeutic agent and a pharmaceutically acceptable carrier, wherein the therapeutic agent is a hydrophobic therapeutic agent with one or more hydrogen-bonding groups and is provided as discrete drug particles in the therapeutic layer, the drug particles have at least one dimension that is less than 25 μηι and are uniformly distributed on the surface of the balloon, and the pharmaceutically acceptable carrier is hydrophilic and has a molecular weight of less than 1,000 Daltons. A process to make the drug-coated medical device and uses thereof are also disclosed.

    摘要翻译： 本文公开了一种具有内表面和外疏水表面的气囊形式的药物涂覆的医疗装置，直接在气囊的外疏水表面上的粘附平衡层，包括亲水性聚合物和/或亲水性化合物，其中 亲水性化合物的分子量小于1,000道尔顿，直接在包含治疗剂和药学上可接受的载体的粘附平衡层上的治疗层，其中治疗剂是具有一个或多个氢键基团的疏水性治疗剂 并且作为治疗层中的离散药物颗粒提供，药物颗粒具有至少一个小于25微米的尺寸并且均匀分布在球囊的表面上，并且药学上可接受的载体是亲水性的并且具有 小于1,000道尔顿。 还公开了制备药物包被的医疗装置及其用途的方法。

    ELECTRICALLY-INDUCED FLUID FILLED BALLOON CATHETER
    4.
    发明申请
    ELECTRICALLY-INDUCED FLUID FILLED BALLOON CATHETER 审中-公开
    电动感应流体填充气泡导管

    公开(公告)号：WO2016109737A1

    公开(公告)日：2016-07-07

    申请号：PCT/US2015/068170

    申请日：2015-12-30

    申请人： THE SPECTRANETICS CORPORATION

    发明人： GRACE, Kenneth, P. ,  TRIFFO, Thomas ,  CEZO, James

    IPC分类号： A61M25/10 ,  A61M25/00

    CPC分类号： A61M25/104 ,  A61B17/22022 ,  A61B2017/22007 ,  A61B2017/22021 ,  A61B2017/22024 ,  A61B2017/22025 ,  A61B2017/22051 ,  A61M37/0092 ,  A61M2025/105 ,  A61M2025/1075 ,  A61M2025/1081 ,  A61M2025/1093 ,  A61M2205/054

    摘要： The present disclosure relates generally to the use of medical devices for the treatment of vascular conditions. In particular, the present disclosure provides devices and methods for using electrically-induced pressure waves to disrupt vascular blockages. The present disclosure not only provides devices and methods for using electrically-induced pressure waves to disrupt vascular blockages, but the present disclosure also provides devices and method for assisting the guidewire in penetrating an occlusion, devices and method for using a sealable valve in the tip of the balloon catheter to reduce the overall size and diameter of the balloon catheter, thereby allowing the balloon catheter to penetrate smaller size blood vessels and devices. Given the persistence of coronary artery disease (CAD) and peripheral artery disease (PAD), there remains a need for improved therapeutic methods designed not only to reduce vascular blockages in the short term, but also to prevent future complications such as restenosis.

    摘要翻译： 本公开一般涉及医疗装置用于治疗血管病症的用途。 特别地，本公开提供了使用电感应压力波来破坏血管阻塞的装置和方法。 本公开不仅提供了使用电诱导的压力波来破坏血管阻塞的装置和方法，而且本公开还提供了用于辅助导丝穿透闭塞的装置和方法，用于在尖端中使用可密封的阀的装置和方法 以减小气囊导管的总体尺寸和直径，从而允许气囊导管穿透较小尺寸的血管和装置。 鉴于冠状动脉疾病（CAD）和外周动脉疾病（PAD）的持续存在，仍然需要改进的治疗方法，不仅在短期内设计减少血管阻塞，而且还防止未来并发症如再狭窄。

    NESTED BALLOONS FOR MEDICAL APPLICATIONS AND METHODS FOR MANUFACTURING THE SAME
    6.
    发明申请
    NESTED BALLOONS FOR MEDICAL APPLICATIONS AND METHODS FOR MANUFACTURING THE SAME 审中-公开
    用于医疗应用的核心气球及其制造方法

    公开(公告)号：WO2016007928A1

    公开(公告)日：2016-01-14

    申请号：PCT/US2015/040056

    申请日：2015-07-10

    申请人： INTERFACE ASSOCIATES, INC.

    发明人： STUPECKY, Josef, J. ,  MABRY, Eric

    IPC分类号： A61M25/10

    CPC分类号： A61M25/1002 ,  A61M25/1011 ,  A61M25/1029 ,  A61M2025/1004 ,  A61M2025/1013 ,  A61M2025/1075 ,  A61M2025/1084 ,  A61M2025/1088

    摘要： A nested balloon is provided where each balloon is formed from tubing that optimizes the inner wall stretch thus providing maximum balloon strength. The high pressure, nested balloon is provided with layers that allow for slipping, such that the balloon has a very high pressure rating and toughness, yet excellent folding characteristics. Methods for producing such nested balloons using existing balloon forming equipment are also provided. The nested balloons can have layers with low-friction surfaces. The nested balloons are preferably manufactured using a variety of methods.

    摘要翻译： 提供嵌套气球，其中每个气球由优化内壁拉伸的管道形成，从而提供最大的球囊强度。 高压嵌套气球设置有允许滑动的层，使得气球具有非常高的压力等级和韧性，但是优异的折叠特性。 还提供了使用现有气囊成形设备来生产这种嵌套气球的方法。 嵌套气球可以具有低摩擦表面的层。 嵌套气球优选使用各种方法制造。

    BULBOUS BALLOON WITH MECHANICAL PRESSURE REGULATOR
    7.
    发明申请
    BULBOUS BALLOON WITH MECHANICAL PRESSURE REGULATOR 审中-公开
    具有机械压力调节器的气瓶

    公开(公告)号：WO2015021065A1

    公开(公告)日：2015-02-12

    申请号：PCT/US2014/049818

    申请日：2014-08-05

    申请人： INTERVALVE, INC.

    发明人： DRASLER, William J. ,  UNGS, Mark ,  PEDERSEN, Wesley R.

    IPC分类号： A61M31/00

    CPC分类号： A61M29/02 ,  A61B2017/22098 ,  A61F2/2427 ,  A61M25/1002 ,  A61M25/1011 ,  A61M25/1018 ,  A61M25/10182 ,  A61M25/10185 ,  A61M25/104 ,  A61M2025/0002 ,  A61M2025/1013 ,  A61M2025/1031 ,  A61M2025/1047 ,  A61M2025/1075 ,  A61M2025/1079 ,  A61M2025/1086 ,  A61M2025/1088

    摘要： A measuring balloon has an inner bulbous balloon formed from a non-compliant or semi-compliant material and has a central smaller diameter inner waist and two larger diameter bulbs on each side of the inner waist. A compliant outer waist bladder is located on the outside of the inner bulbous balloon adjacent to the inner waist and is inflated via a separate inflation lumen. The inner balloon is inflated at a higher pressure to dilate stenotic aortic valve leaflets, and provide alignment and positioning of the measuring balloon across the aortic annulus. The bladder waist is inflated to a lower pressure to make contact with the aortic valve annulus. Marker bands positioned on the outside of the measuring balloon provide determination of annulus diameter and ovality.

    摘要翻译： 测量气球具有由不顺从或半柔顺材料形成的内球囊，并且在内腰的每一侧具有中心较小直径的内腰和两个较大直径的球泡。 柔软的外腰囊位于内球囊球体的与内腰相邻的外侧，并通过单独的充气腔充气。 内球囊在较高压力下膨胀以扩张狭窄的主动脉瓣小叶，并且提供测量球囊在主动脉环上的对准和定位。 膀胱腰部充气到较低的压力以与主动脉瓣环接触。 位于测量气球外侧的标记带可确定环直径和椭圆度。

    MULTILAYER BALLOON FOR A CATHETER
    9.
    发明申请
    MULTILAYER BALLOON FOR A CATHETER 审中-公开
    用于导尿管的多层气囊

    公开(公告)号：WO2014078780A3

    公开(公告)日：2014-09-18

    申请号：PCT/US2013070540

    申请日：2013-11-18

    申请人： ABBOTT CARDIOVASCULAR SYSTEMS

    发明人： LIN TUNG-LIANG ,  LEE JEONG S ,  WHITE ROSEMINDA J ,  WANTINK KENNETH L

    IPC分类号： A61M25/10 ,  A61F2/95

    CPC分类号： A61M25/10 ,  A61F2/958 ,  A61L29/04 ,  A61L29/126 ,  A61M25/1029 ,  A61M25/104 ,  A61M2025/1075 ,  A61M2025/1084

    摘要： Multilayer balloon for a catheter comprises a first layer made of a first polymer material having a first Shore durometer hardness, a second layer made of a second polymer material having a second Shore durometer hardness greater than the first Shore durometer hardness, wherein the second layer is an inner layer relative to the first layer, and a third layer made of a third polymer material having a third Shore durometer hardness less the first Shore durometer hardness, wherein the third layer is an inner layer relative to the second layer. Method of making a multilayer balloon for a catheter and a balloon catheter are also provided.

    摘要翻译： 用于导管的多层气囊包括由具有第一肖氏硬度计硬度的第一聚合物材料制成的第一层，具有大于第一肖氏硬度计硬度的第二肖氏硬度计硬度的由第二聚合物材料制成的第二层，其中第二层是 相对于所述第一层的内层以及由具有小于所述第一肖氏硬度计硬度的第三肖氏硬度计硬度的第三聚合物材料制成的第三层，其中所述第三层是相对于所述第二层的内层。 还提供了制造用于导管和球囊导管的多层球囊的方法。