公开(公告)号：WO2017027654A1

公开(公告)日：2017-02-16

申请号：PCT/US2016/046454

申请日：2016-08-11

Applicant: ACCESS BUSINESS GROUP INTERNATIONAL LLC

Inventor： STODDARD, Ronald, L. ,  MILES, Michael, E. ,  NORCONK, Matthew, J. ,  SCHWANNECKE, Joshua, K. ,  VAN DEN BRINK, Joseph, C. ,  MOORE, Colin, J. ,  UMENEI, A., Esai ,  SCHAMPER, Ryan, D. ,  BARTRUM, Mark, S. ,  MOES, Benjamin, C. ,  VECZIEDINS, Karlis ,  WU, Ziqi ,  SMITH, Mark, C. ,  PIPPEL, Bradley, J. ,  VACHON, David, S.

IPC: A61B8/00 ,  A61N7/00 ,  A61N7/02 ,  B06B3/00 ,  G10K11/24

CPC classification number: A61N7/00 ,  A61B8/4281 ,  A61N7/02 ,  A61N2007/0034 ,  A61N2007/006 ,  A61N2007/0086 ,  G10K11/24

Abstract: An acoustic module with a transducer and a solid waveguide. The transducer and waveguide may be curved to focus the acoustic energy along a focal line. The transducer, the top surface of the waveguide and the bottom surface of the waveguide may extend along coaxial curves. The waveguide may include a recess closely receiving the transducer. The waveguide may include an integral skirt that provides a thermal mass. The acoustic module may include a space to accommodate thermal management options. For example, the acoustic module may include a heatsink, an active ventilation system and/or a phase change material. The ultrasound device may include a controller configured to perform a uniformity scan sweep during supply of operating power to the transducer. The uniformity scan sweep can extend through a frequency range that includes the operating point of the acoustic module and does not exceed an acceptable efficiency loss.

Abstract translation: 具有换能器和固体波导的声学模块。 换能器和波导可以是弯曲的，以沿着焦线聚焦声能。 换能器，波导的顶表面和波导的底表面可以沿同轴曲线延伸。 波导可以包括密封地接收换能器的凹部。 波导可以包括提供热质量的整体裙部。 声学模块可以包括用于容纳热管理选项的空间。 例如，声学模块可以包括散热器，主动通风系统和/或相变材料。 超声装置可以包括控制器，其被配置为在向换能器提供操作功率期间执行均匀扫描扫描。 均匀扫描扫描可以延伸到包括声学模块的操作点的频率范围，并且不超过可接受的效率损失。

公开(公告)号：WO2013103975A8

公开(公告)日：2013-09-19

申请号：PCT/US2013020555

申请日：2013-01-07

Applicant: HISTOSONICS INC

Inventor： BERTOLINA JAMES A ,  RAKIC ALEKSANDRA

IPC: A61B17/225

CPC classification number: A61N7/00 ,  A61B8/12 ,  A61B8/4444 ,  A61B2018/00547 ,  A61B2090/378 ,  A61N7/02 ,  A61N2007/006 ,  A61N2007/0065 ,  A61N2007/0078 ,  A61N2007/0091

Abstract: A Histotripsy therapy transducer is provided that can include any number of features. In some embodiments, the transducer is sized and configured to direct Histotripsy energy through the perineal window into the prostate. The Histotripsy therapy transducer can include a notch or opening near the periphery of the transducer to accommodate a transrectal imaging probe. The notch or opening in the therapy transducer allows for movement of the therapy with respect to the imaging probe without contact or interference from the imaging probe. In some embodiments, the transducer can be "heart-shaped" or round. Methods of use are also described.

Abstract translation: 提供了一种可以包括任意数量特征的组织治疗换能器。 在一些实施方式中，换能器的尺寸和构造被设定为将组织能量通过会阴窗引导到前列腺中。 组织移植治疗换能器可以在换能器外围附近包括凹口或开口以容纳经直肠成像探针。 治疗换能器中的凹口或开口允许治疗相对于成像探针的移动而不接触或来自成像探针的干扰。 在一些实施例中，换能器可以是“心形”或圆形的。 还描述了使用方法。

公开(公告)号：WO2012018386A2

公开(公告)日：2012-02-09

申请号：PCT/US2011/001362

申请日：2011-08-02

Applicant: GUIDED THERAPY SYSTEMS, LLC ,  SLAYTON, Michael, H. ,  BARTHE, Peter, G.

Inventor： SLAYTON, Michael, H. ,  BARTHE, Peter, G.

IPC: A61B18/00 ,  A61N7/00 ,  A61B8/00 ,  A61B8/08

CPC classification number: A61N7/00 ,  A61B8/13 ,  A61B8/14 ,  A61B8/4254 ,  A61B8/4272 ,  A61B8/485 ,  A61B8/5246 ,  A61B17/320068 ,  A61B2018/00642 ,  A61B2018/00898 ,  A61B2090/378 ,  A61N7/02 ,  A61N2007/0013 ,  A61N2007/0034 ,  A61N2007/0052 ,  A61N2007/006 ,  A61N2007/0065 ,  A61N2007/0091 ,  A61N2007/0095 ,  A61N2007/027

Abstract: Various embodiments provide a method for an extended field of view treatment. The method can include the steps of imaging a region; targeting a region with directed ultrasound energy; monitoring the region; moving the imaging, treatment, and monitoring region while spatially correlating to one or more prior regions via imaging and/or position sensing; continuing the extended field of view treatment; and, achieving an ultrasound induced biological effect in the extended field of view treatment region.

Abstract translation: 各种实施例提供用于扩展视野治疗的方法。 该方法可以包括对区域进行成像的步骤; 针对具有定向超声能量的区域; 监测该地区; 移动成像，治疗和监测区域，同时经由成像和/或位置感测在空间上与一个或多个先前区域相关; 继续扩大视野治疗; 并且在扩展的视野治疗区域实现超声诱导的生物效应。

公开(公告)号：WO2011163570A2

公开(公告)日：2011-12-29

申请号：PCT/US2011/041787

申请日：2011-06-24

Applicant: ZETROZ LLC ,  LEWIS JR., George K. ,  GUARINO, JoAnne L. ,  GUFFEY, Bryant

Inventor： LEWIS JR., George K. ,  GUARINO, JoAnne L. ,  GUFFEY, Bryant

IPC: A61B8/00 ,  A61N7/00

CPC classification number: A61N7/00 ,  A61B8/4236 ,  A61B8/4281 ,  A61N2007/0034 ,  A61N2007/0056 ,  A61N2007/006 ,  A61N2007/0078

Abstract: The present invention relates to an ultrasound coupling device that includes a gel component and a coupling compartment. The present invention also relates to various kits and methods for using the ultrasound coupling device with low-intensity ultrasound transducers and therapy. The present invention also relates to methods of making the ultrasound coupling device of the present invention. The present invention further relates to an array that includes a plurality of ultrasound coupling devices of the present invention, and methods of using the array.

Abstract translation: 本发明涉及一种超声耦合装置，其包括凝胶组件和耦合室。 本发明还涉及使用具有低强度超声换能器和治疗的超声耦合装置的各种试剂盒和方法。 本发明还涉及制造本发明的超声波耦合器件的方法。 本发明还涉及包括本发明的多个超声耦合装置的阵列，以及使用阵列的方法。

公开(公告)号：WO2011082407A3

公开(公告)日：2011-11-17

申请号：PCT/US2011020061

申请日：2011-01-03

Applicant: ZETROZ LLC ,  LEWIS GEORGE K JR

Inventor： LEWIS GEORGE K JR

IPC: A61N7/00 ,  A61B18/00 ,  A61H23/00

CPC classification number: A61N7/00 ,  A61B8/4227 ,  A61B8/4236 ,  A61B8/4281 ,  A61B8/44 ,  A61B8/4427 ,  A61B17/2251 ,  A61B2017/00734 ,  A61B2017/2253 ,  A61N2007/006 ,  A61N2007/0078 ,  A61N2007/0091 ,  A61N2007/0095 ,  Y10T29/49005

Abstract: The present invention relates to a portable ultrasound system that can be used for a wide range of ultrasound applications. The portable ultrasound system includes an energy generating module operative to generate a driving signal that can be transformed into ultrasonic energy, where the energy generating module includes a power source, an oscillator, and a driver component. The portable ultrasound system also includes an ultrasound transducer having a piezoelectric component and a lens component. The ultrasound transducer is operative to receive the driving signal from the energy generating module, to transform the driving signal into ultrasonic energy, and to control the direction of the ultrasonic energy emitted from the ultrasound transducer. Also disclosed are devices containing the portable therapeutic ultrasound system of the present invention, as well as methods of using the system.

Abstract translation: 便携式超声波系统技术领域本发明涉及可用于大范围超声应用的便携式超声系统。 便携式超声系统包括能量产生模块，其可操作以产生可转换成超声能量的驱动信号，其中能量产生模块包括电源，振荡器和驱动器部件。 便携式超声系统还包括具有压电元件和透镜部件的超声换能器。 所述超声波换能器用于接收来自所述能量产生模块的驱动信号，以将所述驱动信号转换成超声能量，并且控制从所述超声换能器发射的超声能量的方向。 还公开了包含本发明的便携式治疗超声系统的装置以及使用该系统的方法。

公开(公告)号：WO2011082408A2

公开(公告)日：2011-07-07

申请号：PCT/US2011/020062

申请日：2011-01-03

Applicant: ZETROZ LLC ,  LEWIS JR., George, K.

Inventor： LEWIS JR., George, K.

IPC: H04R17/00

CPC classification number: A61N7/00 ,  A61B8/4227 ,  A61B8/4236 ,  A61B8/4281 ,  A61B8/44 ,  A61B8/4427 ,  A61B17/2251 ,  A61B2017/00734 ,  A61B2017/2253 ,  A61N2007/006 ,  A61N2007/0078 ,  A61N2007/0091 ,  A61N2007/0095 ,  Y10T29/49005

Abstract: The present invention relates to a low-profile ultrasound transducer. The low-profile ultrasound transducer includes a piezoelectric component operative to receive a driving signal from an energy generating module and to emit the driving signal as ultrasonic energy. The piezoelectric component has a front surface and a back surface, and the energy generating module includes a plurality of electronic components. The low-profile ultrasound transducer also includes a lens component directly or indirectly deposited on the front surface of the piezoelectric component. The lens component includes a lens portion and a support portion. The lens portion of the lens component is configured to control the direction and wave pattern of the ultrasonic energy emitted from the piezoelectric component. The support portion of the lens component is configured to hold the piezoelectric component in place and to provide a chamber for housing at least one electronic component of the energy generating module. Methods of use and related devices are also disclosed.

Abstract translation: 本发明涉及一种低轮廓超声波换能器。 该低轮廓超声波换能器包括压电部件，该压电部件操作用于接收来自能量生成模块的驱动信号并且将该驱动信号作为超声波能量发射。 压电部件具有前表面和后表面，并且能量产生模块包括多个电子部件。 低剖面超声波换能器还包括直接或间接沉积在压电部件的前表面上的透镜部件。 透镜组件包括透镜部分和支撑部分。 透镜部件的透镜部分被配置为控制从压电部件发射的超声波能量的方向和波形。 透镜部件的支撑部分构造成将压电部件保持在适当位置并且提供用于容纳能量产生模块的至少一个电子部件的腔室。 还公开了使用方法和相关设备。

公开(公告)号：WO2011082402A2

公开(公告)日：2011-07-07

申请号：PCT/US2011/020052

申请日：2011-01-03

Applicant: ZETROZ LLC ,  LEWIS JR., George K. ,  GUFFEY, Bryant

Inventor： LEWIS JR., George K. ,  GUFFEY, Bryant

IPC: A61N7/00 ,  A61B8/00

CPC classification number: A61N7/00 ,  A61B8/4227 ,  A61B8/4236 ,  A61B8/4281 ,  A61B8/44 ,  A61B8/4427 ,  A61B17/2251 ,  A61B2017/00734 ,  A61B2017/2253 ,  A61N2007/006 ,  A61N2007/0078 ,  A61N2007/0091 ,  A61N2007/0095 ,  Y10T29/49005

Abstract: The present invention relates to an ultrasound coupling device for use with various ultrasound transducers, systems, and applications. The coupling device includes a coupling compartment comprising a chamber having a continuous side wall and an opening on a first end. The continuous side wall is configured to hold a low-profile ultrasound transducer within the chamber so that a front ultrasound emitting surface of the low-profile ultrasound transducer faces outward toward the chamber opening. The front ultrasound emitting surface is configured to control the direction and wave pattern of ultrasonic energy emitted from the transducer. The continuous side wall is also configured to hold a quantity of an ultrasound conductive medium within the chamber and is operative to keep the ultrasound conductive medium in simultaneous contact with a surface of a subject and with at least a portion of the front ultrasound emitting surface of the transducer. The present invention also relates to an ultrasound apparatus, kit, and methods of using the ultrasound coupling device, apparatus, and kit.

Abstract translation: 本发明涉及用于各种超声换能器，系统和应用的超声耦合装置。 该联接装置包括联接隔室，该联接隔室包括具有连续侧壁和第一端上的开口的腔室。 连续的侧壁被配置成将低轮廓超声换能器保持在腔室内，使得低轮廓超声换能器的前超声发射表面朝向腔室开口向外。 前部超声波发射表面被配置为控制从换能器发射的超声波能量的方向和波形。 连续侧壁还被配置为在腔室内保持一定量的超声波导电介质并且可操作以保持超声波导电介质与受试者的表面同时接触，并且与前部超声波发射表面的至少一部分 换能器。 本发明还涉及一种超声设备，套件以及使用该超声耦合装置，设备和套件的方法。

公开(公告)号：WO2015089425A1

公开(公告)日：2015-06-18

申请号：PCT/US2014/070064

申请日：2014-12-12

Applicant: GUIDED THERAPY SYSTEMS, LLC

Inventor： SLAYTON, Michael, H. ,  BARTHE, Peter, G.

IPC: A61N7/02 ,  A61N5/06 ,  A61B18/12 ,  A61B19/00

CPC classification number: A61N7/00 ,  A61B18/12 ,  A61B18/18 ,  A61B18/1815 ,  A61B18/203 ,  A61B2017/00075 ,  A61B2018/00458 ,  A61B2018/1807 ,  A61B2090/065 ,  A61H15/0085 ,  A61H15/0092 ,  A61H15/02 ,  A61H23/0245 ,  A61H2015/0014 ,  A61H2201/0176 ,  A61H2201/0184 ,  A61H2201/105 ,  A61H2201/1685 ,  A61H2201/1695 ,  A61H2201/5028 ,  A61H2201/5038 ,  A61H2201/5046 ,  A61H2201/5064 ,  A61H2201/5082 ,  A61H2201/5092 ,  A61N5/0616 ,  A61N7/02 ,  A61N2007/0034 ,  A61N2007/006 ,  A61N2007/0078

Abstract: This disclosure provides systems and methods for non-invasive treatment to a region of interest with improved efficiency. The systems and methods can include a treatment device having an energy source and a rolling member. The rolling member can include a wall disposed between the energy source and the region of interest. Treatment can be provided at a first location, followed by moving the treatment device, then energy transmission can be terminated if coupling between the energy source and the region of interest is interrupted or treatment can be provided at a second location if the coupling between the energy source and the region of interest is uninterrupted.

Abstract translation: 本公开提供了用于以更高效率对感兴趣区域进行非侵入性治疗的系统和方法。 该系统和方法可以包括具有能量源和滚动构件的处理装置。 滚动构件可以包括设置在能量源和感兴趣区域之间的壁。 可以在第一位置提供治疗，然后移动治疗装置，然后如果能量源和感兴趣区域之间的耦合被中断或如果在能量之间的耦合可以提供治疗，则可以终止能量传输 来源和感兴趣的区域是不间断的。

公开(公告)号：WO2015038886A1

公开(公告)日：2015-03-19

申请号：PCT/US2014/055384

申请日：2014-09-12

Applicant: HOLAIRA, INC.

Inventor： MAYSE, Martin, L. ,  MERTENS, Steven, P. ,  DIMMER, Steven, C.

IPC: A61N7/00 ,  A61B18/00 ,  A61M29/00

CPC classification number: A61N7/02 ,  A61B18/04 ,  A61B18/1492 ,  A61B2018/00011 ,  A61B2018/00023 ,  A61B2018/00279 ,  A61B2018/00285 ,  A61B2018/00541 ,  A61B2018/00577 ,  A61B2018/00982 ,  A61N7/022 ,  A61N2007/003 ,  A61N2007/006 ,  A61N2007/0078 ,  A61N2007/0091

Abstract: A pulmonary treatment system includes a compact configuration for delivery to an airway of a patient. An energy delivery system of the pulmonary treatment system delivers ultrasound energy to target nerve tissue in or along an airway wall of the airway radially outward from surface tissue to reduce airway resistance in a downstream airway. The pulmonary treatment system may protect tissue in the airway wall of the airway located between the target nerve tissue and the ultrasound energy delivery system by a coolant system that may also act as a coupling fluid for the emitted ultrasound energy.

Abstract translation: 肺部治疗系统包括用于输送到患者的气道的紧凑配置。 肺部治疗系统的能量输送系统将表面组织的径向向外的气道的气道壁中的或沿着气道壁的目标神经组织递送超声能量，以降低下游气道中的气道阻力。 肺部治疗系统可以通过也可以作为发射的超声能量的耦合流体的冷却剂系统保护位于目标神经组织和超声能量输送系统之间的气道的气道壁中的组织。

公开(公告)号：WO2013157207A1

公开(公告)日：2013-10-24

申请号：PCT/JP2013/002285

申请日：2013-04-02

Applicant: テルモ株式会社

Inventor： 小林　吏悟 ,  小林　淳一 ,  杉本　良太 ,  平原　一郎

IPC: A61B18/00

CPC classification number: A61N7/022 ,  A61B2017/22068 ,  A61N2007/003 ,  A61N2007/006

Abstract: 　血管挿入型治療デバイス（１００）は挿入体（１０３）と第１の超音波振動子（１０４）とを有する。挿入体（１０３）は両端に基端および挿入端を有する長手形状である。第１の超音波振動子（１０４）は挿入体（１０３）の挿入端近傍に設けられる。第１の超音波振動子（１０４）は長手形状の長手方向から見て放射状に焼灼用超音波を発する。

Abstract translation: 该血管插入型治疗装置（100）具备插入体（103）和第一超声波换能器（104）。 插入体（103）具有纵向形状，其两端是基端和插入端。 第一超声波换能器（104）设置在插入体（103）的插入端附近。 第一超声波换能器（104）产生从纵向形状的纵向方向放射状观察到的烧灼超声波。