公开(公告)号：WO2019126761A1

公开(公告)日：2019-06-27

申请号：PCT/US2018/067306

申请日：2018-12-21

Applicant: SAGE THERAPEUTICS, INC.

Inventor： ROBICHAUD, Albert, Jean ,  SALITURO, Francesco, G. ,  BLANCO-PILLADO, Maria, Jesus ,  LA, Daniel ,  HARRISON, Boyd, L.

IPC: C07J63/00 ,  C07J61/00 ,  A61K31/57 ,  A61P25/00

CPC classification number: C07J63/002 ,  C07J61/00 ,  C07J63/004 ,  C07J63/006 ,  C07J63/008

Abstract: Provided herein is a compound of Formula (I-I) or a pharmaceutically acceptable salt thereof, wherein t, R 7 , R 3 , R 9 , R 6a , R 6b , R 11a , R 11b , R 15a , R 15b , R 16a , R 16b , R 17a , R 17b , R 18a , R 18b , R 19a , R 19b , R 5a , R 5b , R 8 and R 13 are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I-I) and methods of using the compounds, e.g., in the treatment of CNS-related disorders.