公开(公告)号：WO2003023041A2

公开(公告)日：2003-03-20

申请号：PCT/EP2002/009925

申请日：2002-09-05

Applicant: BOEHRINGER INGELHEIM VETMEDICA GMBH ,  ELBERS, Knut ,  MEYER, Christiane ,  VON FREYBURG, Martina ,  MEYERS, Gregor

Inventor： ELBERS, Knut ,  MEYER, Christiane ,  VON FREYBURG, Martina ,  MEYERS, Gregor

IPC: C12N15/86

CPC classification number: C12N7/00 ,  A61K2039/5254 ,  C07K14/005 ,  C12N2770/24022 ,  C12N2770/24061 ,  C12N2770/24321 ,  C12N2770/24322 ,  C12N2770/24361

Abstract: The invention belongs to the field of animal health and in particular Bovine Viral Diarrhea Virus (BVDV). The invention provides infectious BVDV clones and methods to produce said BVDV clones. The invention further relates to methods of attenuating said clones, attenuated BVDV clones and vaccines comprising said attenuated clones.

Abstract translation: 本发明属于动物健康领域，特别是牛病毒性腹泻病毒（BVDV）。 本发明提供感染性BVDV克隆和产生所述BVDV克隆的方法。 本发明还涉及减毒所述克隆，减毒BVDV克隆和包含所述减毒克隆的疫苗的方法。

公开(公告)号：WO1997037686A1

公开(公告)日：1997-10-16

申请号：PCT/AT1997000068

申请日：1997-04-08

Applicant: IMMUNO AKTIENGESELLSCHAFT ,  DORNER, Friedrich ,  BARRETT, Noel ,  EIBL, Johann

Inventor： IMMUNO AKTIENGESELLSCHAFT

IPC: A61K39/12

CPC classification number: A61K39/12 ,  A61K2039/5252 ,  A61K2039/55505 ,  A61L2/0011 ,  A61L2/08 ,  C12N7/00 ,  C12N15/10 ,  C12N2740/16034 ,  C12N2770/24034 ,  C12N2770/24061 ,  C12N2770/24134

Abstract: The invention concerns a process for disintegrating any biologically active nucleic acid in a biological material. According to the invention, a biologically active material is exposed one or a plurality of times to a laser beam in order essentially to disintegrate the entire biologically active nucleic acid in this biological material, whilst the biological integrity and activity of the biological material are retained.

Abstract translation: 本发明涉及一种用于任何生物活性核酸在生物材料，其中生物活性物质的激光束进行崩解所有生物学活性的核酸在该生物材料的一个或更多次是基本上崩解，而生物完整性 和生物材料的活性得以维持。