公开(公告)号：WO2015157431A2

公开(公告)日：2015-10-15

申请号：PCT/US2015/024943

申请日：2015-04-08

Applicant: NOVOGY, INC.

Inventor： GREENHAGEN, Emily H. ,  HAMILTON, Maureen ,  LaTOUF, William G. ,  CONSIGLIO, Andrew L. ,  MacEWEN, Kyle M. ,  SHAW, Arthur J., IV

IPC: C12P7/64 ,  C12N1/21

CPC classification number: C12P13/001 ,  C12N9/78 ,  C12N9/80 ,  C12N9/86 ,  C12N15/52 ,  C12N15/70 ,  C12N15/81 ,  C12P7/6463 ,  C12Y305/01054 ,  C12Y305/01084 ,  C12Y305/02015 ,  C12Y305/04 ,  C12Y305/04003 ,  C12Y305/99004

Abstract: Disclosed are transformed cells and related nucleotide and protein sequences, and fermentation compositions and methods, all of which are related to providing selective advantage in fermentation. For example, a selective advantage results from transformation of a cell with a nucleic acid that allows a transformed cell to metabolize one or more nitrogen-, phosphorous-, and/or sulfur-containing compounds that a native cell of the same species as the transformed cell cannot metabolize, and from fermentation of the transformed cell using one or more feedstocks, such as fractioned grain, which are depleted in or free of conventional nitrogen-, phosphorous-, and/or sulfur-containing compounds that a native cell of the same species as the transformed cell can metabolize. Also disclosed are methods for improved oxygen transfer in an aerobic or microaerobic fermentation.

Abstract translation: 公开了转化细胞和相关的核苷酸和蛋白质序列以及发酵组合物和方法，所有这些都与提供发酵选择性优势有关。 例如，选择性优势是由具有允许转化细胞代谢一种或多种含氮，磷和/或含硫化合物的核酸转化细胞而产生的，所述化合物是与转化的相同种类的天然细胞 细胞不能代谢，并且使用一种或多种原料（例如分馏的谷物）从转化细胞的发酵中分离出来，这些原料贫化或不含常规的含氮，磷和/或含硫化合物，这些化合物是相同的天然细胞 物种作为转化细胞可以代谢。 还公开了在需氧或微氧发酵中改善氧转移的方法。

公开(公告)号：WO2015157431A3

公开(公告)日：2015-12-03

申请号：PCT/US2015024943

申请日：2015-04-08

Applicant: NOVOGY INC

Inventor： GREENHAGEN EMILY H ,  HAMILTON MAUREEN ,  LATOUF WILLIAM G ,  CONSIGLIO ANDREW L ,  MACEWEN KYLE M ,  SHAW ARTHUR J IV

IPC: C12N15/00 ,  C12N1/00

CPC classification number: C12P13/001 ,  C12N9/78 ,  C12N9/80 ,  C12N9/86 ,  C12N15/52 ,  C12N15/70 ,  C12N15/81 ,  C12P7/6463 ,  C12Y305/01054 ,  C12Y305/01084 ,  C12Y305/02015 ,  C12Y305/04 ,  C12Y305/04003 ,  C12Y305/99004

Abstract: Disclosed are transformed cells and related nucleotide and protein sequences, and fermentation compositions and methods, all of which are related to providing selective advantage in fermentation. For example, a selective advantage results from transformation of a cell with a nucleic acid that allows a transformed cell to metabolize one or more nitrogen-, phosphorous-, and/or sulfur-containing compounds that a native cell of the same species as the transformed cell cannot metabolize, and from fermentation of the transformed cell using one or more feedstocks, such as fractioned grain, which are depleted in or free of conventional nitrogen-, phosphorous-, and/or sulfur-containing compounds that a native cell of the same species as the transformed cell can metabolize. Also disclosed are methods for improved oxygen transfer in an aerobic or microaerobic fermentation.

Abstract translation: 公开了转化细胞和相关的核苷酸和蛋白质序列，以及发酵组合物和方法，所有这些都涉及在发酵中提供选择性优势。 例如，选择性优势是由核酸转化细胞产生的，该核酸允许转化的细胞代谢一种或多种与转化物相同物种的天然细胞的含氮，含磷和/或含硫化合物 细胞不能代谢，并且使用一种或多种原料例如分馏的谷物发酵转化细胞，所述原料贫化或不含常规的含氮，含磷和/或含硫化合物，其天然细胞 作为转化细胞的物种可以代谢。 还公开了在好氧或微好氧发酵中改进氧气转移的方法。