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公开(公告)号：WO2017205626A1
公开(公告)日：2017-11-30
申请号：PCT/US2017/034476
申请日：2017-05-25
发明人： DEMIRCI, Hakan , XU, Guan
IPC分类号： G01N29/24 , G01N21/17 , G01N33/574
CPC分类号： G01N21/1702 , A61B5/0095 , A61B8/10 , A61B8/4483 , G01N29/2418 , G01N29/348 , G01N29/46 , G01N2291/015 , G01N2291/02475 , G01N2291/106
摘要： A method of diagnosing intraocular tumors including illuminating a tissue sample using a pulsed light source resulting in output of heat and thermoelastic expansion of the tissue sample. The thermoelastic expansion of the tissue sample produces propagating waves in ultrasonic frequencies. The propagating waves are acquired using an ultrasound system and back-projection reconstruction, thereby mapping anatomies with optical contrast at ultrasonic resolution to image intraocular tumors.
摘要翻译： 诊断眼内肿瘤的方法包括使用脉冲光源照射组织样本，导致组织样本的热量和热弹性膨胀的输出。 组织样本的热弹性膨胀产生超声波频率的传播波。 使用超声系统和背投影重建来获取传播波，由此在超声波分辨率下将解剖学与光学对比映射到图像眼内肿瘤。
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公开(公告)号：WO2016170961A1
公开(公告)日：2016-10-27
申请号：PCT/JP2016/061046
申请日：2016-04-04
申请人： オリンパス株式会社
发明人： 若林 勝裕
CPC分类号： A61B8/4494 , A61B8/12 , A61B8/14 , A61B8/4281 , G01N29/24 , G01N29/2437 , G01N2291/02475 , H04R17/00 , H04R31/00
摘要： 本発明に係る超音波振動子は、複数の圧電素子と、圧電素子に対して電気信号を入出力する基板と、圧電素子と前記基板との間に設けられ、電気的に接続する複数の信号入出力用電極と、複数の圧電素子の前記信号入出力用電極が配設される側に設けられ、該複数の圧電素子の動作によって発せられる力を減衰させる複数のバッキング材と、基板と信号入出力用電極とを接続する電気的な経路の少なくとも一部の外表面を封止する複数の封止部と、を備え、複数の圧電素子、複数のバッキング材、基板の一部、複数の信号入出力用電極および複数の封止部は、それぞれを構成する複数の材料を積層して形成される成形用部材を、該積層方向に沿って分割してなる。
摘要翻译： 根据本发明的超声波换能器设置有：多个压电元件; 用于向压电元件输入/输出电信号的基板; 多个用于电连接压电元件和基板的信号输入/输出电极，其间设置有信号输入/输出电极; 多个背衬材料，用于衰减由多个压电元件的操作所施加的力，所述背衬材料设置在所述多个压电元件的设置有信号输入/输出电极的一侧; 以及用于密封连接基板和信号输入/输出电极的至少一些电路径的外表面的多个密封部件。 多个压电元件，多个背衬材料，基板的一部分，多个信号输入/输出电极和多个密封部分是通过将通过层压多个材料形成的模制构件 构成上述各项，沿着层叠方向。
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公开(公告)号：WO2016134308A1
公开(公告)日：2016-08-25
申请号：PCT/US2016/018762
申请日：2016-02-19
申请人： UNIVERSITY OF SOUTH FLORIDA , TRANSGENEX NANOBIOTECH, INC. , MOHAPATRA, Shyam S. , MOHAPATRA, Subhra , GULDIKEN, Rasim Oytun , NAIR, Rajesh R.
IPC分类号： H03H9/145
CPC分类号： G01N29/022 , G01N29/036 , G01N29/222 , G01N29/2462 , G01N2291/02466 , G01N2291/02475
摘要： A novel SH-SAW biosensor capable of non-invasive and touch-free detection of cancer cell viability and growth or proliferation in two-dimensional (2D) and three-dimensional (3D) cell cultures as well as stem cell regeneration as it pertains to cancer cell biology and anti-cancer drug development is presented. The biosensor includes two pairs of resonators including interdigital transducers reflecting fingers to quantify mass loading by the cells in suspension as well as within a tumoroid culture platform. The biosensor can be part of a perfused 3PNS-tumoroid system that is amenable to real-time non-invasive monitoring of the cell proliferation, viability, and multiplexed detection of key physiologic and clinical biomarkers.
摘要翻译： 一种新型的SH-SAW生物传感器，其能够在二维（2D）和三维（3D）细胞培养物中进行非侵入性和无触摸地检测癌细胞活力和生长或增殖以及干细胞再生，因为它涉及 提出了癌细胞生物学和抗癌药物开发。 生物传感器包括两对谐振器，其包括反指示物的叉指换能器，以量化悬浮液中的细胞以及肿瘤培养平台内的质量负载。 生物传感器可以是灌注的3PNS肿瘤体系的一部分，其可适用于实时非侵入性监测细胞增殖，存活力以及关键生理和临床生物标志物的多重检测。
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4.发明申请
公开(公告)号：WO2016128299A1
公开(公告)日：2016-08-18
申请号：PCT/EP2016/052447
申请日：2016-02-05
发明人： BAUER, Daniel , CHAFIN, David , OTTER, Michael , THEISS, Abbey
IPC分类号： G01N29/024 , G01N29/07 , G01N1/30
CPC分类号： G01N29/024 , G01N1/30 , G01N29/07 , G01N2291/024 , G01N2291/02475
摘要： The subject disclosure presents systems and methods for evaluating a tissue sample that has been removed from a subject. Movement of fluid through the tissue sample is monitored by measuring time of flight of acoustic waves passed through the tissue sample. A system for performing the method can include a transmitter that outputs the energy and a receiver configured to detect the transmitted energy. Using the methods and systems, an optimized protocol for ensuring adequate distribution of the fluid throughout a variety of tissues can be developed.
摘要翻译： 本公开内容提供了用于评估已经从受试者中移除的组织样品的系统和方法。 通过测量通过组织样本的声波的飞行时间来监测通过组织样本的流体的运动。 用于执行该方法的系统可以包括输出能量的发射机和被配置为检测发射能量的接收机。 使用方法和系统，可以开发用于确保流体遍及各种组织的充分分布的优化协议。
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公开(公告)号：WO2016097164A2
公开(公告)日：2016-06-23
申请号：PCT/EP2015080252
申请日：2015-12-17
发明人： OTTER MICHAEL , STEVENS BENJAMIN , BAUER DANIEL
IPC分类号： G01N29/024 , G01N29/07 , G01N29/44
CPC分类号： G01N29/024 , G01N1/30 , G01N29/07 , G01N29/4418 , G01N2291/012 , G01N2291/02475
摘要： The subject disclosure presents systems and computer-implemented methods for determining an acoustic time-of- flight (TOF) of sound waves through a sample material with greater accuracy and in a more repeatable fashion, by invoking one or more of an envelope generation for an error function, fitting a non-linear curve to an ultrasound frequency sweep, or performing a clustered piece-wise linear regression on individual linear parts of the ultrasonic frequency sweep. The systems and methods are useful for, among other things, monitoring diffusion of fluids through porous materials, such as tissue samples.
摘要翻译： 主题公开提供了系统和计算机实现的方法，用于通过调用一个或多个信号生成来确定声波的声波的时间（TOF），其通过样本材料具有更高的精度和更可重复的方式 误差函数，将非线性曲线拟合到超声波扫描中，或对超声波扫描的各个线性部分执行聚类分段线性回归。 这些系统和方法尤其可用于监测流体通过多孔材料如组织样品的扩散。
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公开(公告)号：WO2015103550A1
公开(公告)日：2015-07-09
申请号：PCT/US2015/010181
申请日：2015-01-05
发明人： WANG, Xueding , DENG, Cheri , CARSON, Paul L. , XU, Guan
CPC分类号： G01N29/2418 , A61B5/0095 , A61B2503/40 , A61B2503/42 , G01N21/1702 , G01N29/0654 , G01N29/11 , G01N29/46 , G01N33/4833 , G01N2021/1706 , G01N2291/02475
摘要： A method of performing a photoacoustic physio-chemical analysis is provided. The method includes performing one or more photoacoustic scans on a tissue to generate a plurality of photoacoustic signals. The photoacoustic signals are transformed into a frequency domain to form a power spectra. The method also includes generating a two dimensional (2D) physio-chemical spectrogram from the power spectra. A probe for performing a photoacoustic physio-chemical analysis is also provided.
摘要翻译： 提供了进行光声生理化学分析的方法。 该方法包括在组织上执行一个或多个光声扫描以产生多个光声信号。 光声信号被转换成频域以形成功率谱。 该方法还包括从功率谱产生二维（2D）生理化学谱图。 还提供了用于进行光声生理化学分析的探针。
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公开(公告)号：WO2015077086A2
公开(公告)日：2015-05-28
申请号：PCT/US2014/064992
申请日：2014-11-11
发明人： HAUPT, Robert W.
IPC分类号： A61B8/08
CPC分类号： A61B8/0808 , A61B5/0051 , A61B5/0059 , A61B5/055 , A61B8/08 , A61B8/085 , A61B8/0858 , A61B8/0875 , A61B8/485 , A61B8/488 , A61B8/5215 , A61B8/5223 , G01N29/0654 , G01N29/11 , G01N29/346 , G01N2291/02475 , G01N2291/02491 , G01N2291/02827 , G01N2291/0422 , G01S7/52042 , G01S7/52047 , G01S15/8913 , G01S15/8915
摘要： A system and method for determining tissue changes. Shear waves are transmitted across the tissue in response to an ultrasonic signal input exterior to the tissue surface. Adaptive beam forming signal processing is applied to signal returns and arrivals to remove distortions by targeting velocity contrasts. Shear-wave dispersion, such as due to viscosity and mass changes in the tissue, are then estimated and compared to reference data to determine tissue health.
摘要翻译： 一种用于确定组织变化的系统和方法。 响应于组织表面外部的超声信号输入，剪切波被传送到组织上。 自适应波束形成信号处理被应用于信号返回和到达以通过瞄准速度对比来去除失真。 然后估计剪切波分散，例如由于组织中的粘度和质量变化，并将其与参考数据进行比较以确定组织健康。
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公开(公告)号：WO2015054688A2
公开(公告)日：2015-04-16
申请号：PCT/US2014060293
申请日：2014-10-13
发明人： ZALEV JASON , CLINGMAN BRYAN , HERZOG DONALD
CPC分类号： G01N29/2418 , A61B5/0095 , A61B5/7203 , A61B8/4281 , A61B2560/0223 , A61B2576/00 , G01N29/0654 , G01N2291/023 , G01N2291/02475
摘要： A system is provided for component separation. In an embodiment, a light source or other source of electromagnetic energy delivers energy to a volume of tissue. A transducer array or other sensor receives a resulting acoustic signal, and a processing subsystem processes the acoustic signal to separate a direct acoustic return component from a secondary acoustic return component of the acoustic signal. An output and/or storage device presents and/or stores information about the direct acoustic return component, the secondary acoustic return component, or both. Other embodiments include a coded probe, a probe having an isolator that produces a wavefront, a sensor for measuring intensity of an acoustic wave produced by absorbed photons, and a system that receives acoustic signals from surface targets to determine an optical parameter of the volume.
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公开(公告)号：WO2014113442A1
公开(公告)日：2014-07-24
申请号：PCT/US2014/011631
申请日：2014-01-15
CPC分类号： G01N29/0654 , A61B8/485 , A61B8/587 , G01N29/11 , G01N29/343 , G01N2291/02475
摘要： Systems and techniques for estimating acoustic attenuation in a tissue from time-varying radiation force information generated through the application of acoustic energy to the tissue from at least first and second focal depths are provided. An exemplary technique includes acquiring first signals representing oscillatory motion of the tissue in response to the radiation force proximate the first focal depth, and acquiring second signals representing oscillatory motion of the tissue in response to the radiation force proximate the second focal depth. The technique further includes estimating the oscillatory motion of the tissue from each of the first and second signals, and estimating the acoustic attenuation in the tissue from the estimated oscillatory motion of the tissue from the first and second signals.
摘要翻译： 提供了用于估计从至少第一和第二焦点深度将声能施加到组织产生的时变辐射力信息中的用于估计组织中的声衰减的系统和技术。 示例性技术包括：响应于靠近第一焦点深度的辐射力获取表示组织的振荡运动的第一信号，以及响应于接近第二焦点深度的辐射力获取表示组织的振荡运动的第二信号。 该技术还包括从第一和第二信号中的每一个估计组织的振荡运动，以及根据来自第一和第二信号的组织的估计振荡运动估计组织中的声衰减。
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公开(公告)号：WO2014084976A1
公开(公告)日：2014-06-05
申请号：PCT/US2013/065281
申请日：2013-10-16
发明人： FORSTER, Ian, James
CPC分类号： G01N29/2437 , G01N29/04 , G01N29/12 , G01N29/2481 , G01N2291/02475 , G08C17/02
摘要： This application generally relates to systems and methods of using Radio Frequency Identification (RFID) devices to remotely analyze objects and structures, and more particularly, this application relates to systems and methods of using RFID devices to remotely analyze properties and conditions of a surface of objects and structures.
摘要翻译： 该应用通常涉及使用射频识别（RFID）设备远程分析对象和结构的系统和方法，更具体地说，本申请涉及使用RFID设备远程分析物体表面的性质和状况的系统和方法 和结构。
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