公开(公告)号：WO2021154985A1

公开(公告)日：2021-08-05

申请号：PCT/US2021/015475

申请日：2021-01-28

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： FAN, Xudong ,  WANG, Xueding ,  LI, Xuzhou ,  ZHANG, Wei ,  WANG, William Yanli ,  WU, Xiaoqin ,  TAN, Xiaotian ,  BAKER, Brendon ,  PAULUS, Yannis M.

IPC: G01N21/64 ,  G01N21/62 ,  G01N21/63

Abstract: An imaging system for cell-based therapies is provided. The imagining system includes one or more optical tags configured for insertion into a cell or biological tissue, an excitation light source configured to illuminate the one or more optical tags; a detector configured to measure optical emission of the one or more optical tags; an imaging subsystem configured to determine a three-dimensional location of each of the one or more optical tags in the cell or biological tissue; and a controller in electrical communication with the excitation light source, the detector, and the imaging subsystem. Each of the one or more optical tags has a contrasting feature and includes a fluorescent material. The contrasting feature may be defined by at least one of a refractive index, shape, color, and laser emission of each optical tag of the one or more optical tags.

公开(公告)号：WO2007084981A2

公开(公告)日：2007-07-26

申请号：PCT/US2007/060764

申请日：2007-01-19

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  WANG, Xueding ,  CHAMBERLAND, David

Inventor： WANG, Xueding ,  CHAMBERLAND, David

IPC: A61B18/18

CPC classification number: A61B18/24 ,  A61B18/26 ,  A61B2017/00106 ,  A61B2090/364 ,  A61B2090/378

Abstract: A system and method for monitoring laser therapy of a target tissue include a therapeutic control unit having a first light source configured to deliver light to the target tissue for therapy, an ultrasonic transducer for receiving photoacoustic signals generated due to optical absorption of light energy by the target tissue, and a monitoring control unit in communication with the ultrasonic transducer for reconstructing photoacoustic tomographic images from the received photoacoustic signals to provide an optical energy deposition map of the target tissue. A second light source utilized for imaging may also be provided.

Abstract translation: 用于监视目标组织的激光治疗的系统和方法包括治疗控制单元，该治疗控制单元具有被配置为向目标组织递送光以用于治疗的第一光源，用于接收由于治疗而产生的光声信号的超声换能器 由目标组织对光能的光吸收;以及监控控制单元，与超声换能器通信，用于根据接收到的光声信号重建光声层析图像，以提供目标组织的光学能量沉积图。 还可以提供用于成像的第二光源。

公开(公告)号：WO2007100937A3

公开(公告)日：2007-09-07

申请号：PCT/US2007/060762

申请日：2007-01-19

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  WANG, Xueding ,  CHAMBERLAND, David ,  CARSON, Paul ,  FOWLKES, Brian

Inventor： WANG, Xueding ,  CHAMBERLAND, David ,  CARSON, Paul ,  FOWLKES, Brian

IPC: A61B8/00

Abstract: A system and method for spectroscopic photoacoustic tomography of a sample include at least one light source configured to deliver light pulses at two or more different wavelengths to the sample. An ultrasonic transducer is disposed adjacent to the sample for receiving photoacoustic signals generated due to optical absorption of the light pulses by the sample. A control system is provided in communication with the ultrasonic transducer for reconstructing photoacoustic tomographic images from the received photoacoustic signals, wherein upon application of light pulses of two or more different wavelengths to the sample, the control system is configured to determine the local spectroscopic absorption of substances at any location in the sample. The system may further provide for one or more of ultrasound imaging, Doppler ultrasound imaging, and diffuse optical imaging of the sample.

公开(公告)号：WO2020146637A1

公开(公告)日：2020-07-16

申请号：PCT/US2020/012939

申请日：2020-01-09

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： FAN, Xudong ,  WANG, Xueding ,  LI, Xuzhou ,  QIN, Yu ,  TAN, Xiaotian ,  CHEN, Yu-Cheng ,  CHEN, Qiushu

IPC: H01S3/213 ,  H01S3/20 ,  H01S3/10 ,  H01S3/08 ,  H01S3/094 ,  G01N21/62 ,  G01N21/63 ,  C09K11/06

Abstract: A laser whose emission is modulated by ultrasound is presented. The laser is usually micron-sized. In response to ultrasound modulation, the laser emission increases and decreases. Such a change in emission can be detected by external optical detectors. This type of laser can be used as a new type of imaging modality, in which laser emission in combination with sound waves or ultrasound waves, is used for imaging. Laser emission has a much narrower spectral linewidth and stronger intensity than fluorescence and therefore is able to achieve higher sensitivity, whereas sound waves are used to provide a better spatial resolution of the laser emission from the laser. In ultrasound modulated laser based imaging, multiple lasers can be placed inside cells or tissues.

公开(公告)号：WO2015103550A1

公开(公告)日：2015-07-09

申请号：PCT/US2015/010181

申请日：2015-01-05

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： WANG, Xueding ,  DENG, Cheri ,  CARSON, Paul L. ,  XU, Guan

IPC: A61B8/08 ,  A61B5/00 ,  G01N29/14

CPC classification number: G01N29/2418 ,  A61B5/0095 ,  A61B2503/40 ,  A61B2503/42 ,  G01N21/1702 ,  G01N29/0654 ,  G01N29/11 ,  G01N29/46 ,  G01N33/4833 ,  G01N2021/1706 ,  G01N2291/02475

Abstract: A method of performing a photoacoustic physio-chemical analysis is provided. The method includes performing one or more photoacoustic scans on a tissue to generate a plurality of photoacoustic signals. The photoacoustic signals are transformed into a frequency domain to form a power spectra. The method also includes generating a two dimensional (2D) physio-chemical spectrogram from the power spectra. A probe for performing a photoacoustic physio-chemical analysis is also provided.

Abstract translation: 提供了进行光声生理化学分析的方法。 该方法包括在组织上执行一个或多个光声扫描以产生多个光声信号。 光声信号被转换成频域以形成功率谱。 该方法还包括从功率谱产生二维（2D）生理化学谱图。 还提供了用于进行光声生理化学分析的探针。

公开(公告)号：WO2008103982A3

公开(公告)日：2008-08-28

申请号：PCT/US2008/054874

申请日：2008-02-25

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  CHAMBERLAND, David, L. ,  WANG, Xueding ,  CARSON, Paul ,  WOOD, David ,  MONTIE, James

Inventor： CHAMBERLAND, David, L. ,  WANG, Xueding ,  CARSON, Paul ,  WOOD, David ,  MONTIE, James

IPC: A61N5/06

Abstract: A system and method for monitoring photodynamic therapy of a target tissue, where the target tissue contains a photosensitizing substance, include a first light source configured to deliver light to the target tissue, the first light source having a wavelength capable of exciting the photosensitizing substance. An ultrasonic transducer receives photoacoustic signals generated due to optical absorption of light energy by the target tissue, and a control unit in communication with the ultrasonic transducer reconstructs photoacoustic tomographic images from the received photoacoustic signals to provide an indication of optical energy deposition due to the photosensitizing substance in the target tissue.