公开(公告)号：WO1997035519A1

公开(公告)日：1997-10-02

申请号：PCT/US1997004848

申请日：1997-03-25

Applicant: GASTON, Benjamin, M., IV ,  HUNT, John, F.

IPC: A61B05/08

CPC classification number: A61B5/083

Abstract: Disclosed is a device for determination of the content of higher oxides of nitrogen in exhaled breath condensate which comprises a conduit (7) having an exhaling condensing portion with an inlet and an outlet (the inlet can be configured to fit with a mechanical respirator, or for direct use by a patient, an inlet assembly providing one-way ingress (2) of ambient atmosphere so the device can be associated with the inlet of the conduit exhaling condensing portion); a coolant jacket (6) coaxially surrounding said exhaling condensing portion; a gas release port; and, in an enclosed fluid communication with said conduit exhaling condensing portion outlet, a sample assay assembly (9) comprising the following: (a) a translucent analysis chamber attached to the outlet to receive condensate fluid and having a reagent port; (b) a reagent chamber in enclosed fluid communication with the reagent entry port; and (c) a pliable element connecting the oulet and the analysis chamber and forming a portion of the reagent chamber such that flexion of the pliable element closes communication between the oulet and the analysis chamber and contracts the reagent chamber so as to deliver to the analysis chamber controlled amounts of condensate and reagent. The device is disposable and inexpensive, and is used to collect human exhaling for colorimetric assay of liquid and gas phase nitrogen oxides to assist in evaluation of airway inflammation.

Abstract translation: 公开了一种用于确定呼出气体冷凝物中较高氧化氮含量的装置，其包括具有带入口和出口的排气冷凝部分的导管（该入口可配置成与机械呼吸器配合，或 由患者直接使用，入口组件提供环境大气的单向入口（2），因此该装置可与导管排出冷凝部分的入口相关联）; 围绕所述排气冷凝部分的冷却剂套（6）; 气体释放口; 并且在与所述导管排出冷凝部分出口的封闭流体连通中，包括以下的样品测定组件（9）：（a）连接到出口以接收冷凝物流体并具有试剂口的半透明分析室; （b）与所述试剂入口封闭流体连通的试剂室; 和（c）连接所述分离室和所述分析室的柔性元件，并且形成所述试剂室的一部分，使得所述柔韧元件的屈曲闭合所述底座和所述分析室之间的连通并收缩所述试剂室以便输送到所述分析 室内控制量的冷凝物和试剂。 该装置是一次性和便宜的，并且用于收集人呼气以进行液相和气相氮氧化物的比色测定以帮助评估气道炎症。

公开(公告)号：WO1996024285A1

公开(公告)日：1996-08-15

申请号：PCT/US1996001538

申请日：1996-02-06

Applicant: RAYBURN, Daniel, B.

IPC: A61B05/08

CPC classification number: A61B5/412 ,  A61B5/0836

Abstract: A non-invasive system and procedure for deriving the blood gas content for a patient. The system measures the carbon dioxide concentration of the expiratory breath relative to volume. This data is then processed to derive arterial blood gas levels of carbon dioxide. If data sampling is in the time domain, the processing shifts the data from the time domain to the volume domain. The processing also iteratively assesses the significance of numerous variables. The resulting relationship provides a fast and accurate measure of blood gas content for both healthy and diseased lung patients.

Abstract translation: 用于导出患者血液含气量的非侵入性系统和程序。 该系统测量呼气相对于体积的二氧化碳浓度。 然后处理该数据以得到二氧化碳的动脉血气水平。 如果数据采样处于时域，则处理将数据从时域转移到卷域。 该处理也迭代地评估了许多变量的意义。 所产生的关系为健康和患病肺部患者提供了一种快速准确的血气含量测量。

公开(公告)号：WO1995010980A1

公开(公告)日：1995-04-27

申请号：PCT/US1994011665

申请日：1994-10-13

Applicant: MEDTRAC TECHNOLOGIES INC.

Inventor： MEDTRAC TECHNOLOGIES INC. ,  WOLF, James, L. ,  SALLIS, Daniel, V.

IPC: A61B05/08

CPC classification number: A61B5/0878 ,  G06F19/00

Abstract: This invention is a spirometric device (100) for analyzing the strength of the exhalation of a patient. The device (100) is designed to sense and measure exhaled airflow rate, exhaled breath temperature, determine airflow volume, and record and display the respiratory movement of the patient for helping make medication recommendations. The device (100) includes an electronic package (336) mounted inside a housing (110) for computing and recording the strength, the temperature, and the volume of the exhalation along with the time and date. The device (100) includes a replaceable airflow chamber (130) mounted on the housing (110). A disposable mouthpiece (140) is releasably attached to the airflow chamber. A hot wire (430) is disposed inside the airflow chamber (130) and provides for measuring both airflow rate and temperature. An output of the hot wire (430) is connected to electronic circuitry (305) inside the housing for determining the proper volumes along with recording the time and date of the event.

Abstract translation: 本发明是用于分析患者呼气强度的肺量测装置（100）。 设备（100）被设计成感测和测量呼出的气流速率，呼出呼气温度，确定气流量，以及记录和显示患者的呼吸运动以帮助药物建议。 设备（100）包括安装在壳体（110）内的电子封装（336），用于计算和记录呼气的强度，温度和体积以及时间和日期。 装置（100）包括安装在壳体（110）上的可更换气流室（130）。 一次性接口（140）可释放地附接到气流室。 热线（430）设置在气流室（130）的内​​部，并且用于测量气流速率和温度。 热线（430）的输出连接到壳体内部的电子电路（305），用于确定适当的体积以及记录事件的时间和日期。

公开(公告)号：WO1994009700A1

公开(公告)日：1994-05-11

申请号：PCT/US1993005819

申请日：1993-06-16

Applicant: HOOD LABORATORIES ,  Biomechanics Inc. ,  FREDBERG, Jeffrey ,  GLASS, Gary ,  LEHR, John ,  LOUIS, Bruno

Inventor： HOOD LABORATORIES ,  Biomechanics Inc.

IPC: A61B05/08

CPC classification number: A61B8/12 ,  A61B5/085

Abstract: Single hand supportable and operable apparatus (30) for providing an output signal characteristic of the morphology of a respiratory tract includes an acoustic pipe (30) for exchanging acoustical energy with the tract. The pipe has an open first end (34) in communication with an opening in the respiratory tract. A transducer (38), such as a loudspeaker, is coupled to the pipe, producing an incident wave towards to opening in the tract and a reflected wave to form a transient wave filed in the pipe representative of the morphology of the tract. Preferably, first (40) and second pressure wave sensing transducers (42), such as microphones, mounted along the length of the pipe in spaced relationship provide first and second transduced signals representative of the transient wave field. A processor (66) processes the first and second transduced signals to provide an output signal characteristic of the morphology of the tract, such as the cross-sectional area as a function of the distance from the opening of the tract.

Abstract translation: 用于提供呼吸道形态特征的输出信号的单手支持和可操作装置（30）包括用于与声道交换声能的声管（30）。 管道具有与呼吸道中的开口连通的敞开的第一端（34）。 诸如扬声器的换能器（38）耦合到管道，产生朝向在管道中打开的入射波和反射波，以形成代表管道形态的管道中的瞬时波。 优选地，沿间隔开的管的长度安装的第一（40）和第二压力波感测换能器（例如麦克风）提供代表瞬态波场的第一和第二转换信号。 处理器（66）处理第一和第二转导信号以提供特征的道的形态的输出信号，例如横截面积作为距道的开口的距离的函数。

公开(公告)号：WO1993012719A1

公开(公告)日：1993-07-08

申请号：PCT/US1992011267

申请日：1992-12-29

Applicant: MAULT, James, R.

IPC: A61B05/08

CPC classification number: A61B5/083

Abstract: A calorimeter for generating signals representative of the oxygen consumption and carbon dioxide production of a subject over a test period (12) includes two flow sensors (48, 64) and a carbon dioxide scrubber (66) connected to a patient mouthpiece (60). Interconnections (44, 46, 52, 54, 56, 58, 62) are such that the air inhaled by the subject passes through one flow meter and the exhaled breath passes first through the other flow meter, the carbon dioxide scrubber and then through the first flow meter. The electrical output signals from the flow meters are provided to a microprocessor based computer (50) which integrates the volume differences between the inhaled gas, and the exhaled gas after the carbon dioxide has been removed from it, over the period of the test.

Abstract translation: 用于产生表示测试期间（12）中受试者的氧消耗和二氧化碳产生的信号的量热计包括两个流量传感器（48,64）和连接到患者接口（60）的二氧化碳洗涤器（66）。 相互连接（44,46,52,54,56,58,62）使得受试者吸入的空气通过一个流量计，并且呼出的呼吸首先通过另一个流量计，二氧化碳洗涤器，然后通过 第一流量计 来自流量计的电输出信号被提供给基于微处理器的计算机（50），其在测试期间将吸入气体和二氧化碳从其中除去的呼出气体之间的体积差积分。

公开(公告)号：WO1991017706A1

公开(公告)日：1991-11-28

申请号：PCT/US1991003348

申请日：1991-05-14

Applicant: CNS, INC.

Inventor： CNS, INC. ,  REITEN, Denise, M.

IPC: A61B05/08

CPC classification number: A61B5/4818 ,  A61B5/1135

Abstract: A volume change sensor (11, 12) having an elongated tubular enclosure (15) with a thin deformable wall having a conduit (13) for connection to a pressure monitor (14), there being an elongated insert material (24) within the tubular enclosure that is wider than it is thick at some locations formed from resiliently deformable open cell foam. An elastic belt (16) against which the tubular enclosure is positioned is used to wrap it about a respirating subject (10) undergoing corresponding changes to measure same.

Abstract translation: 具有细长管状外壳（15）的体积变化传感器（11,12）具有薄的可变形壁，该可变形壁具有用于连接到压力监视器（14）的导管（13），所述管状外壳中的细长插入材料（24） 在由可弹性变形的开孔泡沫塑料形成的某些位置，其宽度比其厚。 使用管状外壳所定位的弹性带（16）将其包裹在经历相应变化的呼吸对象（10）上以测量相同的变化。

公开(公告)号：WO1989011823A1

公开(公告)日：1989-12-14

申请号：PCT/US1989002505

申请日：1989-06-08

Applicant: VITAL SIGNALS, INC.

Inventor： VITAL SIGNALS, INC. ,  KORTEN, Jerome, B. ,  SCHULZE, Karl, F.

IPC: A61B05/08

CPC classification number: A61B5/087 ,  A61B5/7239 ,  G06F19/00 ,  G06F19/3481 ,  G16H40/63

Abstract: An apparatus and method are disclosed for monitoring physiological parameters associated with the ventilation of infants during assisted ventilation. The infant is placed in a plethysmograph and various sensor means are used to measure flow of gas into and out of the plethysmograph and infant respiration. The outputs of the sensor means are supplied to a microcomputer system for processing. A unique calibration system is provided which constantly corrects for changing system parameters such as plethysmographic chamber air leaks, compliance and the like. Additionally, a heating system which exhibits radiant as well as convective heating properties is provided to maintain the infant in a constant temperature environment with a minimal amount of temperature fluctuation. From this data, ventilator breaths are discriminated from infant breaths.

公开(公告)号：WO1985002104A1

公开(公告)日：1985-05-23

申请号：PCT/FR1984000258

申请日：1984-11-12

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE LOUIS PASTEUR (STRASBOURG I) ,  SPEICH, Jean-Pierre ,  ZOULOUMIAN, Pierre, Joseph

Inventor： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE LOUIS PASTEUR (STRASBOURG I)

IPC: A61B05/08

CPC classification number: A61M16/20 ,  A61B5/08 ,  A61B5/085 ,  A61M16/0858 ,  A61M2209/02

Abstract: A quick occlusion controlled device particularly intended to evaluate the sensitivity of respiratory centres comprises a body (1) connected to the respiratory apparatus of the patient through a buccal connector (2), provided with a pressure tap (3). According to the invention, the device is characterized in that the body (1) comprises an inspiration connector (4) which opens into the inner volume of the body (1) through a valve (5), as well as a respiration connector (6) which opens into the inner volume of the body (1) through a second valve (7), said device being further provided with an occlusion means of both/either of the valves (5) and (7).

Abstract translation: 特别旨在评估呼吸中枢的敏感性的快速阻塞控制装置包括通过设置有压力分接头（3）的颊部连接器（2）连接到患者的呼吸装置的主体（1）。 根据本发明，该装置的特征在于，主体（1）包括通过阀（5）向主体（1）的内部容积以及呼吸连接器（6）打开的吸气连接器（4） ），其通过第二阀（7）进入主体（1）的内部容积，所述装置还设置有两个/任一阀（5）和（7）的闭塞装置。

公开(公告)号：WO1984001704A1

公开(公告)日：1984-05-10

申请号：PCT/SE1983000370

申请日：1983-10-28

Applicant: KAROLINSKA INSTITUTET ,  LINNARSSON, Dag ,  RIBBE, Tommy ,  MATELL, Georg

Inventor： KAROLINSKA INSTITUTET

IPC: A61B05/08

CPC classification number: A61B5/087

Abstract: An arrangement for measuring bidirectional respiration flow, including a hose (1) which is connected to the breathing passages of a patient in which, via a Y-piece (2) is also connected to a tube (3) for inspiration gas and to a tube (4) for expiration gas. The tubes (3, 4) are connected to a breathing apparatus. Each tube has a venturi means arranged therein. According to the invention a pressure differential meter (8) having two inlets is connected with one inlet to each venturi means. A magnet valve (7) is arranged to periodically connect both inlets together, and there is provided an electronic means (9) for calculating the valve measured and for controlling the zero-setting, to which end the control means is connected electrically to the pressure differential meter (8) and to the magnet valve (7).

Abstract translation: 一种用于测量双向呼吸流量的装置，包括连接到患者的呼吸通道的软管（1），其中，通过Y型片（2）也连接到用于吸入气体的管（3）和 管（4）用于呼气。 管（3,4）连接到呼吸器。 每个管具有布置在其中的文丘里装置。 根据本发明，具有两个入口的压差计（8）与每个文氏管装置的一个入口连接。 电磁阀（7）被布置成周期性地将两个入口连接在一起，并且设置有用于计算所测量的阀并用于控制零点设置的电子装置（9），控制装置的哪一端电连接到压力 差速计（8）和磁阀（7）。

公开(公告)号：WO1981002512A1

公开(公告)日：1981-09-17

申请号：PCT/US1980000316

申请日：1980-03-10

Applicant: AMERICAN HOSPITAL SUPPLY CORP

Inventor： AMERICAN HOSPITAL SUPPLY CORP ,  ELINGS V ,  LEWIS F

IPC: A61B05/08

CPC classification number: A61B5/028

Abstract: Apparatus for providing a measure of extravascular lung water of a subject using a single thermal indicator, including means (16) for providing an injection of the thermal indicator into the bloodstream of the subject at a position proximal to or in the right heart (10) means (26) for detecting a first time-temperature concentration curve of the bloodstream at a position in the pulmonary artery, means (104) responsive to the first time-temperature concentration curve detected in the pulmonary artery for calculating a characteristic time for the first time-temperature concentration curve, means (28) for detecting a second time temperature concentration curve of the bloodstream at a position in a systemic artery, means (104) responsive to the second time-temperature concentration curve detected in the systemic artery for calculating a characteristic time for the second time-temperature concentration curve, means (104) for calculating the flow of blood through the heart and lungs, and means (104) for calculating a measure of extra-vascular lung water in accordance with the difference between the products of the blood flow times the first characteristic time and the blood flow times the second characteristic time.

Abstract translation: 用于使用单个热指示器提供受试者的血管外肺水的量度的装置，包括用于在靠近或右心脏（10）的位置处提供热指示器注射到受试者血流中的装置（16） 用于检测在肺动脉位置处的血流的第一时间 - 温度浓度曲线的装置（26），响应于在肺动脉中检测到的第一时间 - 温度浓度曲线来计算第一个 时间 - 温度浓度曲线，用于检测全身动脉位置处的血流的第二时间温度浓度曲线的装置（28），响应于在全身动脉中检测到的第二时间 - 温度浓度曲线计算 第二时间 - 温度浓度曲线的特征时间，用于计算通过心脏和肺的血流量的手段（104），以及 ns（104），用于根据血流量与第一特征时间之间的差异与血液流过第二特征时间计算血管外肺水的量度。