WIRELESS CLOSED-LOOP SMART BANDAGE FOR CHRONIC WOUND MANAGEMENT AND ACCELERATED TISSUE REGENERATION

    公开(公告)号:WO2023028349A1

    公开(公告)日:2023-03-02

    申请号:PCT/US2022/041756

    申请日:2022-08-26

    Abstract: Chronic non-healing wounds represent a major source of morbidity for patients, and a significant economic burden. Current wound care treatments are passive and are unable to adapt to changes in the wound environment in real time. By integrating multimodal sensors and adding stimulators in a bandage, physiological monitoring is possible and provides an opportunity for active intervention into the complex wound environment. Here, we develop a battery -free flexible bioelectronic system consisting of wirelessly powered, closed-loop, autonomous sensing and stimulation circuits with tissue-interfacing tough conducting hydrogel electrodes for robust signal transduction, on-demand adhesion, and detachment. Using multiple pre-clinical models, we demonstrate the capability of our wound care system to continuously monitor skin impedance and temperature, while delivering directional electrical stimulation, leading to the activation of pro-regenerative genes linked to accelerated wound closure, increased neovascularization, and enhanced dermal recovery.

    检测方法和装置
    7.
    发明申请

    公开(公告)号:WO2021238503A1

    公开(公告)日:2021-12-02

    申请号:PCT/CN2021/088363

    申请日:2021-04-20

    Inventor: 王庆刚

    Abstract: 一种涉及检测技术领域的检测方法和装置。该方法包括:响应于待测用户的双手置于该检测装置的预设交互区域内,执行以下检测步骤:向双手发射电信号,以及接收该双手的反馈信号,其中,该反馈信号用于生成该双手的电阻抗信息;检测该双手的生物电信号,其中,该生物电信号用于生成该待测用户的心电信息;对该双手发射预设波长的光,以及利用该检测装置中的光敏传感器接收反射光,其中,该反射光用于生成该待测用户的血流相关指标信息。该方法和装置可以实现通过一个检测装置,对待测用户的多项身体指标进行高效、准确地检测,并且仅利用待测用户的双手,获取到上述的多项身体指标。

    PROBE AND MEASUREMENT SYSTEM
    8.
    发明申请

    公开(公告)号:WO2021139971A1

    公开(公告)日:2021-07-15

    申请号:PCT/EP2020/086209

    申请日:2020-12-15

    Abstract: A probe (200) for combined impedance and light absorbance measurement on skin (202) comprises a two-dimensional array (206) of skin-facing sub-probes (208), each skin-facing sub-probe (208) comprising an optical fiber end (210, 211) coated, around its circumference, with an electrode (212). A measurement system (100) is configured for simultaneous impedance and light measurement on skin (202), and comprises the probe (200), an impedance measurement device (118) configured for pairwise impedance measurement across a plurality of pairs of electrodes (212) of the skin-facing sub-probes (208); and a light measurement device (112) configured for the light absorbance measurement through a plurality of optical fiber ends (210, 211) of the skin-facing sub-probes.

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